@article { author = {Dinarvand, Negar and Azizi, Reza}, title = {Histamine and Food Allergy}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {100-111}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.1}, abstract = {Histamine is synthesized via histidine decarboxylase (HDC) in wide types of immune cells and is involved in abundant physiologic and pathologic processes. Histamine is a mediator released during inflammatory reactions, such as food allergy. Food allergy is immunological reactions to 'fight off' specific allergens within food in susceptible individuals. The aim of this study is investigation of the histamine hemostasis and food allergy to discover the relationship between them. Analysis of data from multiple electronic databases such as Scopus, PubMed, Google Scholar and Science Direct were performed. Various criteria were applied to select the articles for inclusion.Food allergy reaction is divided to 4 types of the immune response. These reactions with different mechanisms cause increased concentrations of histamine. Histamine does various action in different tissue. The correct and timely diagnosis of food allergy can lead to reduction of the chemicals release and inhibit of abnormal reaction of the body. According to some studies, Measurement of N-methylhistamine (NMH) as the major metabolite of histamine may help to diagnose patients with food-allergen induced clinical symptoms.}, keywords = {histamine,food allergy,histidine decarboxylase}, url = {https://www.ijabbr.com/article_36418.html}, eprint = {https://www.ijabbr.com/article_36418_b54ac688ac703ce36180d53b57bb40f3.pdf} } @article { author = {Paul, Sunanda and Kumer, Ajoy and Sarker, Md. Nuruzzaman and Islam, Mohammad Jahidul}, title = {The effect of halogen atoms at propanoate anion on thermo physical, vibrational spectroscopy, chemical reactivity, biological properties of morpholinium propionate Ionic Liquid}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {112-127}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.2}, abstract = {The morpholinium cation based ionic liquids are designed to evaluate the thermophysical, chemical reactivity, and biological activity. To estimate and design the bioactive ILs, propionate and trihalopropanoate were considered under theoretical study by Density Functional Theory (DFT). To make effect of halogens atom on anion, propionate, trifluro propionate, trichloro propionate, and tribromo propionate were taken for optimization. Some thermodynamic and thermophysical properties such as free energy, entropy, dipole moment, binding energy, nuclear energy, electronics energy, and heat of formation were calculated using DFT method and make a comparative effect for halogen atoms activity on anion. The free energy, binding energy, and heat of formation were the highest on morphonium trifluro propionate (IL02) and the second is on tribromo propionate (IL04). Quantitative Structure Activity Relationship (QSAR) like charge density, surface area grid, volume, LogP, polarizability, refractivity, and molecular mass were simulated and recorded, from which the biological activity was calculated. The chemical reactivity like HOMO, LUMO, HOMO-LUMO gap, ionization potential, hardness, softness electronegativity and electron affinity were calculated. The vibrational spectroscopy and UV spectroscopy data provide them the identification and characterization. To sum up, the thermophysical properties are highly affected by trifluro propionate anion then tribromo propionate, trichloro propionate, and propionate respectively. On the other hand, the chemical reactivity increases in order IL04, IL03, IL02, IL01 but biological activity is inversely changed.}, keywords = {Morpholine,DFT,HOMO- LUMO,QSAR,and Vibrational spectroscopy}, url = {https://www.ijabbr.com/article_36498.html}, eprint = {https://www.ijabbr.com/article_36498_1f4f53c940d14c01aa897ef8d836fc18.pdf} } @article { author = {Fakhr Hosseini, Seyed Mojtaba and Aiubi, Saman}, title = {Introduction of Microbial as a Major Factor in the Human Body}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {128-133}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.3}, abstract = {The aim of this study is introduction on microbials as an effective agent in the human body. Microbial (symbiotic microorganisms) means the general and universal ecosystem of riches, all genes and masses of micronutrients, regardless of their genera and species, are referred to in a particular section. The symbiotic microbials have a symbiotic relationship with host creatures. This means that these microbes can also be partners, both pathogens. For example, all bacteria, fungi and other types of germs that live natively in the human skin are called microbiotics. The largest microbial of the human body is the microbioum of the digestive tract and, in particular, the large intestine. This term, although used more in medicine, is also valid in other branches of microbiology. They play an important role in health and disease. And trillions of bacteria, called microbials, that make up our bodies in our societies, involve the release of chemicals in the method of digestion, the delivery of medication, and the development and development of diseases such as heart disease, metabolic disorders (metabolism), or even cancer progression.}, keywords = {Microbial,Main factor,Microbium of the lower digestive system,Intestinal microbial}, url = {https://www.ijabbr.com/article_36853.html}, eprint = {https://www.ijabbr.com/article_36853_1750f9c171d46b9d8b4842f5fab7e05e.pdf} } @article { author = {Rahmati, Masome}, title = {The recent development in synthesis and pharmacological evaluation of small molecule to treat Alzheimer's diseases: A review}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {134-145}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.4}, abstract = {Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. A neurodegenerative type of dementia, the disease starts mild and gets progressively worse. Like all types of dementia, Alzheimer's is caused by brain cell death. The most common presentation marking Alzheimer's dementia is where symptoms of memory loss are the most prominent, especially in the area of learning and recalling new information.Alzheimer's disease is not simple to diagnose. There is no single test for it. For this reason, the first thing doctors do is to rule out other problems before confirming whether mental signs and symptoms are severe enough to be a kind of dementia or something else. Genetic test is possible in some settings to indicate the likelihood of someone having or developing the disease but this is controversial and not entirely reliable. There are no disease-modifying drugs available for Alzheimer's disease but some options may reduce its symptoms and help improve quality of life. A different kind of drug, memantine, an NMDA receptor antagonist, may also be used, alone or in combination with a cholinesterase inhibitor. This review highlights the several reports that attempt to design and synthesis of some classes of selective Alzheimer's disease inhibitors.}, keywords = {Alzheimer's disease,dementia,neurodegenerative disease,β-amyloid inhibitors}, url = {https://www.ijabbr.com/article_36889.html}, eprint = {https://www.ijabbr.com/article_36889_01c80f4efee03204aea480694623f4fd.pdf} } @article { author = {Khatri, Narayan and Rawal, Nabin and Chalise, Devraj and Bista, Mamata and Pandey, Bisheshwor}, title = {Effect of crop residue and nitrogen levels in yield and yield attributing traits of rice under Rice-Wheat Cropping System}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {146-152}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.5}, abstract = {A 3- years (2015, 2016 and 2017) field study was carried out at National Wheat Research Program, Bhirahawa, Rupandehi, Nepal to evaluate the influence of crop residues and nitrogen levels on rice. The experiment was conducted in split plot design with three replications. Main plots were two crop residue levels (with crop residues of 30 cm wheat stubble and without crop residues) and sub plots consisted of seven nitrogen levels (0, 25, 50, 75, 100, 125 and 150 kg N ha-1). Combined analysis of three years data revealed that crop residue levels did not differ significantly in terms of grain yield; however crop residues incorporation increased the rice grain yield slightly. Significant difference was observed with application of different nitrogen levels in grain yield and yield attributing characters viz; tillers m-2, panicle length, number of filled grains per panicle and thousands grain weight. Rice grain yield was found at increasing rate with increased level of nitrogen @ 150 kg ha-1. Application of nitrogen @ 150 kg ha-1 gave highest grain yield of 4831kg ha-1 which was found at par with nitrogen @ 125 kg ha-1 with grain yield of 4722 kg ha-1. Crop residues with nitrogen @ 125 kg ha-1 resulted in 216 kg ha-1 higher rice grain yield than residues removed treatment. The overall conclusion is that an improved crop residue management with 125 kg N ha-1 increases the grain yield of rice in long run.}, keywords = {Crop residue,Nitrogen levels,Rice,Yield}, url = {https://www.ijabbr.com/article_36905.html}, eprint = {https://www.ijabbr.com/article_36905_20a430350789a9892c3a012574272386.pdf} } @article { author = {Zarei, Mohammad and Ghafaryan, Hero}, title = {Alfa-Glucosidase inhibitory and antioxidant activity of hexane extract of flowers, leave and stems of Haplophyllum acutifolium DC. and Ferula haussknechtii Wolff ex Rech.}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {153-164}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.6}, abstract = {Background:α-Glucosidase Inhibition can significantly prevent glucose uptake after meal, and helps in controlling of some adverse effects in diabetics. So determination of α-Glucosidase inhibitory effect and antioxidant activity of the Haplophyllum acutifolium and Ferula haussknechtii aerial organs was the aim of this study.Methods:Inhibitory effect of hexane extracts from different organs was investigated in several concentrations at 405 nm wavelength using a microplate reader. Antioxidant activity of hexane extracts of various organs was also measured using DPPH and iron reduction tests. Results;The highest inhibitory activity of F.haussknechtii was observed at the 0.1 g/ml concentration of flower extract (100% inhibition and IC50= 0.1 μg /ml) and the most inhibitory activity of H.acutifolium, was related to the 1 g/ml concentration of flower extract (100% inhibition and IC50 = 10 μg /ml) and leaf extract (100% inhibition and IC50 = 60 μg /ml). Extract of H.acutifolium flower and leaves showed Non-competitive inhibition pattern and F.haussknechtii flower showed mixed (Competitive -Non-Competitive) inhibitory pattern at 0.001 g/ml and exhibit uncompetitive inhibitory pattern at the 0.1 g/ml. The results of antioxidant potential showed EC50 for F.haussknechtii flower and H.acutifolium leaves equalled 2.37 and 0.96 mg/ml, respectively. Conclusions:The hexane extract of the F.haussknechtii flower, and H.acutifolium flower and leaf organ have a significant inhibitory effect on the activity of α-Glucosidase, DPPH free radical scavenging activities and reducing power. So they are good resources for extraction of medicinal compounds to control blood level of glucose after meal, in diabetic patients.}, keywords = {Alpha-glucosidase,Ferula haussknechtii,Haplophyllum acutifolium,diabetes,Enzymatic inhibition}, url = {https://www.ijabbr.com/article_37040.html}, eprint = {https://www.ijabbr.com/article_37040_a961bb1129e0b09532a2e416598d46d3.pdf} } @article { author = {fakhari, rasoul and tobeh, ahmad and alebrahim, mohammadtaghi and Mehdizadeh, Mohammad and Karbalaei Khiavi, Hossein}, title = {Study of Changes in Activity of Wheat Antioxidant Enzymes under Stress Residue of Imazethapyr Herbicide}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {165-179}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.7}, abstract = {In order to investigate physiological and biochemical changes of wheat under stress residue of Imazethapyr herbicide (Imazethapyr), an experiment was conducted in a completely randomized design with four replications in greenhouse conditions at university of Mohaghegh Ardebili. The treatments consisted of five dose levels of herbicide Imazethapyr (0, 0.011, 0.022, 0.033 and 0.044 micrograms of herbicide) per kilogram of soil. The analysis of variance showed that the content of the main and auxiliary pigments of leaf, proline, sugar content, protein, activity of catalase enzymes, peroxidase, polyphenol oxidase, root and shoot dry weight were significantly affected by herbicide. The results showed the Imazethapyr herbicide stopped the production of valine leucine and isoleucine amino acids. As a result, the rapid reduction in the volume of these amino acids led to a reduction in protein synthesis in wheat plant. Therefore, the application of doses of 0.011, 0.022, 0.033 and 0.044 micrograms of herbicides decreased 14, 26, 44 and 47 percent of leaf protein content, respectively, compared with control treatment. Further, theapplication of these doses resulted in the reduction of 2.8, 5, 27 and 64% of activity of catalase enzyme, 3.5, 39, 49 and 52% peroxidase enzyme activity and 13, 24, 35 and 46% activity of polyphenol oxidase enzyme, compared with control treatment. The results revealed that Imazethapyr herbicide activates wheat antioxidant enzymes to reduce plant tolerance from damage caused by herbicide residues; therefore, it can be used as a marker or index of herbicide damage rate in physiological research.}, keywords = {Carotenoid,Catalase,Peroxidase,Proline}, url = {https://www.ijabbr.com/article_37119.html}, eprint = {https://www.ijabbr.com/article_37119_25fba138650a17b60df74c23b8a0baa3.pdf} } @article { author = {talleh, mohsen and Rafiee Dastjerdi, Hooshang and Nasser, Bahram and Sheikhi Garjan, Aziz and Talebi Jahromi, Khalil}, title = {Effects of emamectin benzoate combined with acetamiprid, eforia and hexaflumuron against Tuta absoluta (Lep.: Gelechiidae)}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {180-192}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.8}, abstract = {Tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most destructive pests of tomato in many parts of the world including Iran. The toxicity of emamectin benzoate alone and combined with acetamiprid, eforia (thiamethoxam + lambda-cyhalotrin) and hexaflumuron was evaluated against 2nd instar larvae of Tuta absoluta (Meyrick) under 25 ± 1 °C, the relative humidity of 75 ± 5% and a photoperiod of 16:8 (L:D). Also the mixtures of tested insecticides with emamectin benzoate at LC15:LC15 ratio were evaluated on the activity of general esterase enzyme and total protein content of 2nd instar larvae. After 96 hour, emamectin benzoate had the highest toxicity (LC50 = 0.52 mg A.I./L), followed by acetamiprid (LC50 = 56.39 mg A.I./L) and eforia (LC50 = 312.01 mg A.I./L). Hexaflumuron showed no toxicity against larvae. The combination of emamectin benzoate with acetamiprid at LC50:LC50 ratio produced synergistic effects and all of the other ratios showed additive effects. The emamectin benzoate combined with either eforia or hexaflumuron at all of the ratios produced additive and antagonistic effects, respectively. Esterase activity of larvae increased when emamectin benzoate was mixed with either acetamiprid or eforia, but no significant differences were seen between emamectin benzoate alone and its mixture with hexaflumuron. The combination of emamectin benzoate with tested insecticides significantly reduced the total protein content of larvae. According to the results of this study, the mixtures of acetamiprid and eforia with emamectin benzoate showed higher negative impacts against 2nd instar larvae than emamectin benzoate alone}, keywords = {mixture,esterase,Total Protein,emamectin benzoate,Tuta absoluta}, url = {https://www.ijabbr.com/article_37168.html}, eprint = {https://www.ijabbr.com/article_37168_ad17db39a3b4ba91b1860fcdf0ab3f75.pdf} } @article { author = {Endalemaw, Chalacew and Semahegn, Zigale}, title = {Genetic Variability and Yield Performance of Sorghum}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {193-213}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.9}, abstract = {The experiment was conducted using Randomized Complete Block Design with Row Column arrangement and three replications. Grain yield, phenological and other traits were recorded. The Residual Maximum Likelihood (REML) combined analysis of variance across locations showed very highly significant (P}, keywords = {Early maturing,Correlation,cluster,Heritability,Spatial model}, url = {https://www.ijabbr.com/article_37176.html}, eprint = {https://www.ijabbr.com/article_37176_b63e5855a3084eb049304a5759c9d434.pdf} } @article { author = {Hamidipour, Neda and Fazeli, Mehdi and Hedayati, Mehdi and Dehghani, Mohsen and Gerami, Razieh}, title = {PI3K/Akt/mTOR and CDK4 combined inhibition enhanced apoptosis of thyroid cancer cell lines}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {8}, number = {2}, pages = {214-224}, year = {2020}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.33945/SAMI/IJABBR.2020.2.10}, abstract = {Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and BCPAP cell lines were evaluated by MTT assay. The suitable concentrations of inhibitors were determined and synergistic effects of such inhibitors were evaluated by bax/bcl-2 mRNA ratio, Caspase-3, and Caspase-9 activity assay as well as Akt, mTOR, and CDK4. Results:Our finding showed that both ATC and BCPAP cell proliferation is significantly inhibited by PD-332991(PD) and NVP-BEZ235 (NVP) in a time and concentration-dependent manner (P}, keywords = {Thyroid cancer,Carcinoma,Apoptosis,NVP-BEZ235,PD-332991}, url = {https://www.ijabbr.com/article_37195.html}, eprint = {https://www.ijabbr.com/article_37195_0e855a37795618c586a97567e37a95dc.pdf} }