@article { author = {ABBA, ABDULKARIM and Nnenna, Ukwuani-Kwaja and NWAOGU, JUDE}, title = {Antidiabetic, Antioxidant and Hypolipidemic potentials of Sterculia Setigera Methanol Stem Bark Extract in Alloxan-Induced Diabetic Rats}, journal = {International Journal of Advanced Biological and Biomedical Research}, volume = {10}, number = {1}, pages = {84-97}, year = {2022}, publisher = {Sami Publishing Company}, issn = {2383-2762}, eissn = {2322-4827}, doi = {10.22034/ijabbr.2022.546271.1375}, abstract = {Background: Sterculia setigera is one of the medicinal plants used traditionally to treat various diseases with the insertion of diabetes. Diabetes mellitus is a prolonged metabolic disorder recognized as a hyperglycemia. The present study is aimed at investigating the antidiabetic activity of the methanol stem bark extract of Sterculia setigera. Methods: LD50 screening was evaluated using standard methods. The sub-chronic effect of Sterculia setigera methanol stem bark extract on body weight, antidiabetic, antioxidant, lipid profile and histopathology were evaluated in Alloxan-induced diabetic rats respectively. Result: Acute toxicity study of methanol stem bark extract of Sterculia setigera reveal no mortality in the animals at the limit dose of 5000mg/kg during the 14 days observation period. In the invivo study, alloxan was capable of inducing diabetic conditions as there was a significant increase (P<0.05) in the fasting blood glucose (FBG) of the entire induced groups compared to normal control. Groups treated with crude extract of Sterculia setigera (100-400mg/kg) and the standard drug (glibenclamide) showed a significant decrease (P<0.05) in FBg compared to diabetics control. There were significant reductions (P<0.05) in serum TC, TG, VLDL, LDL, CAT, SOD, GPx, Vit E, Vit A, and MDA against diabetic control. On the other hand, significant increments (P<0.05) in body weight and HDL were observed in the treated groups compared to diabetic control diabetic. Histopathological examination showed improvement in the regeneration of pancreatic β-cells islets. Conclusion: In conclusion, Sterculia setigera stem bark extract exhibit hypoglycaemic, hypolipidemic, and antioxidant effects justifying its ethnomedicinal use for the treatment of diabetes.}, keywords = {Keywords: Antidiabetic,alloxan,Sterculia setigera,hypolipidemic,Antioxidant,Glibenclamide}, url = {https://www.ijabbr.com/article_251226.html}, eprint = {https://www.ijabbr.com/article_251226_06d182015ceda536ea2588075b18daa6.pdf} }