%0 Journal Article %T N-Acetylcysteine Overdose After Acetaminophen Poisoning %J International Journal of Advanced Biological and Biomedical Research %I Sami Publishing Company %Z 2383-2762 %A Razlansari, Ali Akbar %A Jafrasteh, Azadeh %A Garmsiri, Mahshid %D 2017 %\ 06/01/2017 %V 5 %N 2 %P 69-72 %! N-Acetylcysteine Overdose After Acetaminophen Poisoning %K N-acetylcysteine %K Overdose %K Medication error %R 10.26655/ijabbr.2017.3.4 %X N-acetylcysteine (NAC) is a drug  used  widely and effectively in oral  and  ‎intravenous  forms  as  a  specific  antidote  for acetaminophen poisoning.  In children ‎considering the toxic dose of acetaminophen ingested by the patient and the body weight, the ‎physician prescribes a specific dose of NAC. There is always a risk of  iatrogenic overdose of  ‎NAC  which can cause different mild to severe temporary or permanent  side effects, some of ‎which can be life threatening. Here we report a rare case of iatrogenic NAC overdose following ‎an error in calculation of the prescribed dose.‎The patient was a 2.5 years old boy that was brought to emergency room with overdose ‎of acetaminophen syrup. The Physician prescribed 2 grams of intravenous NAC for him, but ‎because of the miscalculation of the volume of the drug, the nurse infused about 20 grams of ‎NAC (10 times the prescribed dose) to the patient. Immediately the patient became drowsy and ‎developed decreased level of consciousness, stupor, repetitive intractable focal and generalized ‎convulsions, decrease visual acuity and had prolonged hospitalization in intensive care unit and ‎pediatric neurologic wards and perhaps will have permanent subtle intellectual and neurologic ‎sequela. Considering the possible errors in the prescription and administration of some ‎critical and less commonly used drugs especially those which have several different formulary ‎and also considering their possible serious and life threatening side effects, it is recommended ‎that the dose and volume of such medications be calculated meticulously by at least two trained ‎persons. Also it is important to carry out the administration phases and check the patient’s ‎symptoms more attentively and cautiously. ‎ %U https://www.ijabbr.com/article_26460_941022481dde86c3723be5dd45a8e213.pdf