ORIGINAL_ARTICLE
Histamine and Food Allergy
Histamine is synthesized via histidine decarboxylase (HDC) in wide types of immune cells and is involved in abundant physiologic and pathologic processes. Histamine is a mediator released during inflammatory reactions, such as food allergy. Food allergy is immunological reactions to 'fight off' specific allergens within food in susceptible individuals. The aim of this study is investigation of the histamine hemostasis and food allergy to discover the relationship between them. Analysis of data from multiple electronic databases such as Scopus, PubMed, Google Scholar and Science Direct were performed. Various criteria were applied to select the articles for inclusion.Food allergy reaction is divided to 4 types of the immune response. These reactions with different mechanisms cause increased concentrations of histamine. Histamine does various action in different tissue. The correct and timely diagnosis of food allergy can lead to reduction of the chemicals release and inhibit of abnormal reaction of the body. According to some studies, Measurement of N-methylhistamine (NMH) as the major metabolite of histamine may help to diagnose patients with food-allergen induced clinical symptoms.
https://www.ijabbr.com/article_36418_b54ac688ac703ce36180d53b57bb40f3.pdf
2020-06-01
100
111
10.33945/SAMI/IJABBR.2020.2.1
histamine
food allergy
histidine decarboxylase
Negar
Dinarvand
kolsomdinarvandkdinarvand92@yahoo.com
1
Department of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan,Iran.
AUTHOR
Reza
Azizi
azizirr@yahoo.com
2
Department of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan,Iran.
LEAD_AUTHOR
Anagnostou, K, Meyer, R, Fox, A, Shah, N. (2015). The rapidly changing world of food allergy in children. F1000Prime Rep., 7:35.
1
Backhaus, B, Raithel, M, Hahn, E. (2005). Nicht-immunologisch induzierte Histaminfreisetzung an vitalen menschlichen Darmschleimhautbiopsien durch Stimulation mit Polyaminen. Allergo J., 14:41.
2
Bakker, RA, Schoonus, SB, Smit, MJ, Timmerman, H, Leurs, R. (2001). Histamine H1-receptor activation of nuclear factor-κB: roles for Gβγ-and Gαq/11-subunits in constitutive and agonist-mediated signaling. Mol. Pharmacol., 60(5):1133-1142.
3
Bäumer, W, Wendorff, S, Gutzmer, R, Werfel, T, Dijkstra, D, Chazot, P, Stark, H, Kietzmann, M. (2008). Histamine H4 receptors modulate dendritic cell migration through skin–immunomodulatory role of histamine. Allergy, 63(10):1387-1394.
4
Berin, MC, Sampson, HA. (2013). Food allergy: an enigmatic epidemic. Trend. Immunol., 34(8):390-397.
5
Bhowmik, M, Khanam, R, Vohora, D. (2012). Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives. Br. J. Pharmacol., 167(7):1398-1414.
6
Boyce, JA, Assa'ad, A, Burks, AW, Jones, SM, Sampson, HA, Wood, RA, Plaut, M, Cooper, SF, Fenton, MJ, Arshad, SH, Bahna, SL, Beck, LA, Byrd-Bredbenner, C, Camargo, CA, Eichenfield, L, Furuta, GT, Hanifin, JM, Jones, C, Schwaninger, JM. (2011). Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. J. Am. Academy Dermatol., 64(1):175-192.
7
Coruzzi, G, Adami, M. (2008). Peripheral actions and therapeutic potential in periphery. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders. Boca Raton, CRC Press Taylor & Francis, p. 167-209.
8
Coruzzi, G, Adami, M, Pozzoli, C. (2012). Role of histamine H4 receptors in the gastrointestinal tract. Front Biosci (Schol Ed), 4:226-239.
9
De Benedetto, A, Yoshida, T, Fridy, S, Park, JE, Kuo, IH, Beck, LA. (2015). Histamine and skin barrier: are histamine antagonists useful for the prevention or treatment of atopic dermatitis? J. Clin. Med., 4(4):741-755.
10
Del Valle, J, Gantz, I. (1997). Novel insights into histamine H2receptor biology. Am. J. Phys. Gastroint. Liver Physiol., 273(5):G987-G996.
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Griffiths, C. E. M., & Barker, R. D. R. (2004). Psoriasis. In: Rook-W. Wilkinsum Ebling. Text book of dermatology, Last ed. Blackwell Science.
12
Gutowska‐Owsiak, D, Greenwald, L, Watson, C, Selvakumar, TA, Wang, X, Ogg, GS. (2014). The histamine‐synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin. Br. J. Dermatol., 171(4):771-778.
13
Gutzmer, R, Gschwandtner, M, Rossbach, K, Mommert, S, Werfel, T, Kietzmann, M, Baeumer, W. (2011). Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus. Front Biosci (Schol Ed), 3:985-994.
14
Hanuskova, E, Plevkova, J. (2013). The role of histamine H4 receptors as a potential targets in allergic rhinitis and asthma. Open J. Mol. Integrat. Physiol., 3(01):6.
15
Ho, MHK, Wong, WHS, Chang, C. (2014). Clinical spectrum of food allergies: a comprehensive review. Clin. Rev. Allergy Immunol., 46(3):225-240.
16
Horr, B, Borck, H, Thurmond, R, Grösch, S, Diel, F. (2006). STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes. Int. immunopharmacol., 6(10):1577-1585.
17
Jemima, EA, Prema, A, Thangam, EB. (2014). Functional characterization of histamine H4 receptor on human mast cells. Mol. Immunol., 62(1):19-28.
18
Jutel, M, Akdis, M, Akdis, C. (2009). Histamine, histamine receptors and their role in immune pathology. Clin. Experiment. Allergy, 39(12):1786-1800.
19
Kumar, S, Verma, AK, Das, M, Dwivedi, PD. (2012). Molecular mechanisms of IgE mediated food allergy. Int. immunopharmacol., 13(4):432-439.
20
Leurs, R, Bakker, RA, Timmerman, H, de Esch, IJ. (2005). The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat. Rev. Drug Discov., 4(2):107-120.
21
Leurs, R, Vische, HF, Wijtman, M, de Esc, IJ. (2011). En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family. Trend. Pharmacol. Sci., 32(4):250-257.
22
Lim, HD, van Rijn, RM, Ling, P, Bakker, RA, Thurmond, RL, Leurs, R. (2005). Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J. Pharmacol. Exper. Therapeut., 314(3):1310-1321.
23
Maintz, L, Novak, N. (2007). Histamine and histamine intolerance. Am. J. Clin. Nutrit., 85(5):1185-1196.
24
Novak, N, Kraft, S, Bieber, T. (2001). IgE receptors. Curr. Opin. Immunol., 13(6):721-726.
25
Parrish, C. P., Kim, E. H., & Bird, J. A. (2018). Interventional Therapies for the Treatment of Food Allergy. Immunology and allergy clinics of North America, 38(1), 77-88.
26
Raithel, M, Küfner, M, Ulrich, P, Hahn, EG. (1999). The involvement of the histamine degradation pathway by diamine oxidase in manifest gastrointestinal allergies. Inflammat. Res., 48(13):75-76.
27
Schwelberger, HG. (2004). Histamine N-methyltransferase (HNMT) enzyme and gene. Histamine: biology and medical aspects. Budapest, Hungary: SpringMed Publishing, p. 53-9.
28
Schwelberger, HG. (2004). Diamine oxidase (DAO) enzyme and gene. Histamine: biology and medical aspects. Budapest, Hungary: SpringMed Publishing, p. 43-52.
29
Stone, KD, Prussin, C, Metcalfe, DD. (2010). IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol., 125(2):S73-S80.
30
Verhoeckx, KCM, Vissers, YM, Baumert, JL, Faludi, R, Feys, M, Flanagan, S, Herouet-Guicheney, C, Holzhauser, T, Shimojo, R, van der Bolt, N, Wichers, H, Kimber, I. (2015). Food processing and allergenicity. Food Chem. Toxicol., 80:223-240.
31
Yanai, K, Tashiro, M. (2007). The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies. Pharmacol. Therapeut., 113(1):1-15.
32
Żukiewicz-Sobczak, WA, Wróblewska,P, Adamczuk, P, Causes, PK. (2013). symptoms and prevention of food allergy. Advances in Dermatology and Allergology, Postepy. Dermatol. Alergol., 30(2):113.
33
ORIGINAL_ARTICLE
The effect of halogen atoms at propanoate anion on thermo physical, vibrational spectroscopy, chemical reactivity, biological properties of morpholinium propionate Ionic Liquid
The morpholinium cation based ionic liquids are designed to evaluate the thermophysical, chemical reactivity, and biological activity. To estimate and design the bioactive ILs, propionate and trihalopropanoate were considered under theoretical study by Density Functional Theory (DFT). To make effect of halogens atom on anion, propionate, trifluro propionate, trichloro propionate, and tribromo propionate were taken for optimization. Some thermodynamic and thermophysical properties such as free energy, entropy, dipole moment, binding energy, nuclear energy, electronics energy, and heat of formation were calculated using DFT method and make a comparative effect for halogen atoms activity on anion. The free energy, binding energy, and heat of formation were the highest on morphonium trifluro propionate (IL02) and the second is on tribromo propionate (IL04). Quantitative Structure Activity Relationship (QSAR) like charge density, surface area grid, volume, LogP, polarizability, refractivity, and molecular mass were simulated and recorded, from which the biological activity was calculated. The chemical reactivity like HOMO, LUMO, HOMO-LUMO gap, ionization potential, hardness, softness electronegativity and electron affinity were calculated. The vibrational spectroscopy and UV spectroscopy data provide them the identification and characterization. To sum up, the thermophysical properties are highly affected by trifluro propionate anion then tribromo propionate, trichloro propionate, and propionate respectively. On the other hand, the chemical reactivity increases in order IL04, IL03, IL02, IL01 but biological activity is inversely changed.
https://www.ijabbr.com/article_36498_1f4f53c940d14c01aa897ef8d836fc18.pdf
2020-06-01
112
127
10.33945/SAMI/IJABBR.2020.2.2
Morpholine
DFT
HOMO- LUMO
QSAR
and Vibrational spectroscopy
Sunanda
Paul
paulsunda.bmb@gmail.com
1
Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong,Hathazari-4334, Bangladesh
AUTHOR
Ajoy
Kumer
kumarajoy.cu@gmail.com
2
Chemistry, European University of Bangladesh, Dhaka, Bangladesh
LEAD_AUTHOR
Md. Nuruzzaman
Sarker
nuruzzamansust@gmail.com
3
Department of Physics, European University of Bangladesh, Dhaka-1216, Bangladesh
AUTHOR
Mohammad Jahidul
Islam
jahidulkhan106490@gmail.com
4
Department of Physics, European University of Bangladesh, Dhaka-1216, Bangladesh
AUTHOR
Böhm, M, St rzebecher, J, Klebe, G. (1999). Three-dimensional quantitative structure− activity relationship analyses using comparative molecular field analysis and comparative molecular similarity indices analysis to elucidate selectivity differences of inhibitors binding to trypsin, thrombin, and factor Xa. J. Med. Chem., 42(3):458-477.
1
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2
Collins, KD. (1997). Charge density-dependent strength of hydration and biological structure. Biophys. J., 72(1):65-76.
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Freitas, VL, Gomes, JRB, Ribeiro da Silva, MDMC. (2014). Energetics and reactivity of morpholine and thiomorpholine: a joint experimental and computational study. J. Chem. Eng. Data, 59(2):312-322.
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5
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6
Hossain, MI, Kumer, A. (2017). Synthesis and Characterization of Ammonium Ionic Liquids and Their Antimicrobial and Computational Overview. Asian J. Phys. Chem. Sci., 3(4):1-10.
7
Hossain, MI, Kumer, A. (2017). Synthesis and characterization of ammonium benzilate bioactive ionic liquids and their antimicrobial activity. Asian J. Phys. Chem. Sci., 4(4):1-13.
8
Hossain, MI, Kumer, A. Begum, S. (2018). Synthesis and Characterization of Ammonium Benzoate and Its Derivative Based Ionic Liquids and Their Antimicrobial Studies. Asian J. Phys. Chem. Sci., 5(1):1-9.
9
Hossain, MI, El-Harbawi, M, Kumer, A. (2015). Acute toxicity of OH functionalized ionic liquids to the aquatic species. Int. J. Adv. Eng. Sci. Technol., (IJAEST), 4(3):244-249.
10
Howard, A, J. McIver, et al. (1994). Hyperchem computational chemistry. Hypercube Inc., Waterloo.
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Islam, MJ, Kumer, A, Sarker, N, Paul, S, Zannat, A. (2019). The prediction and theoretical study for chemical reactivity, thermophysical and biological activity of morpholinium nitrate and nitrite ionic liquid crystals: A DFT study. Adv. J. Chem. Section A, 2(4):316-326.
12
Islam, MJ, Sarker, N, Kumer, A, Paul, S. (2019). The Evaluation and Comparison of Thermo-Physical, Chemical and Biological Properties of Palladium(II) Complexes on Binuclear Amine Ligands with Different Anions by DFT Study. Int. J. Adv. Biol. Biomed. Res., 7(4):15-334.
13
Izquierdo, I. (1979). Effect of naloxone and morphine on various forms of memory in the rat: Possible role of endogenous opiate mechanisms in memory consolidation. Psychopharmacology, 66(2):199-203.
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15
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16
Kumer, A, Sarker, N, Paul, S. (2019). The Simulating Study of HOMO, LUMO, thermo physical and Quantitative Structure of Activity Relationship (QSAR) of Some Anticancer Active Ionic Liquids. Eurasian J. Environ. Res., 3(3):1-10.
17
Kumer, A, Sarker, N, Paul, S. (2019). The thermo physical, HOMO, LUMO, Vibrational spectroscopy and QSAR study of morphonium formate and acetate Ionic Liquid Salts using computational method. Turkish Computat. Theoret. Chem., 3(2):59-68.
18
Kumer, A, Sarker, N, Paul, S. (2019). The Theoretical Prediction of Thermophysical properties, HOMO, LUMO, QSAR and Biological Indics of Cannabinoids (CBD) and Tetrahhdrocannabinol (THC) by Computational Chemistry. Adv. J. Chem. Section A, 2(3):190-202.
19
Kumer, A, Sarker, N, Paul, S. (2019). The theoretical investigation of HOMO, LUMO, thermophysical properties and QSAR study of some aromatic carboxylic acids using HyperChem programming. Int. J. Chem. Technol., 3(1):26-37.
20
Kumer, A, Sarker, N, Paul, S. Afroza Z. (2019). The Theoretical Prediction of Thermophysical properties, HOMO, LUMO, QSAR and Biological Indics of Cannabinoids (CBD) and Tetrahhdrocannabinol (THC) by Computational Chemistry. Adv. J. Chem., 3(3):1-13.
21
Kumer, A, Sarker, N, Paul, S. (2019). The theoretical investigation of HOMO, LUMO, thermophysical properties and QSAR study of some aromatic carboxylic acids using HyperChem programming. Int. J. Chem. Technol., 3(1):26-23.
22
Lanman, BA, Myers, AG. (2004). Efficient, stereoselective synthesis of trans-2, 5-disubstituted morpholines. Org. Lett., 6(6):1045-1047.
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Martini, L, Whistler, JL. (2007). The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Current Opin. Neurobiol., 17(5):556-564.
24
Newington, I, Perez-Arlandis, JM, Welton, T. (2007). Ionic liquids as designer solvents for nucleophilic aromatic substitutions. Org. Lett., 9(25):5247-5250.
25
Timofeeva, L, Kleshcheva, N. (2011). Antimicrobial polymers: mechanism of action, factors of activity, and applications. Appl. Microbial. Biotechnol., 89(3):475-492.
26
Wang, XS, Tabor, MW. (1988). Studies of the reactivity of morpholine, 2‐mercaptobenzothiazole and 2 of their derivatives with selected amino acids. Contact Dermatitis., 19(1):16-21.
27
ORIGINAL_ARTICLE
Introduction of Microbial as a Major Factor in the Human Body
The aim of this study is introduction on microbials as an effective agent in the human body. Microbial (symbiotic microorganisms) means the general and universal ecosystem of riches, all genes and masses of micronutrients, regardless of their genera and species, are referred to in a particular section. The symbiotic microbials have a symbiotic relationship with host creatures. This means that these microbes can also be partners, both pathogens. For example, all bacteria, fungi and other types of germs that live natively in the human skin are called microbiotics. The largest microbial of the human body is the microbioum of the digestive tract and, in particular, the large intestine. This term, although used more in medicine, is also valid in other branches of microbiology. They play an important role in health and disease. And trillions of bacteria, called microbials, that make up our bodies in our societies, involve the release of chemicals in the method of digestion, the delivery of medication, and the development and development of diseases such as heart disease, metabolic disorders (metabolism), or even cancer progression.
https://www.ijabbr.com/article_36853_1750f9c171d46b9d8b4842f5fab7e05e.pdf
2020-06-01
128
133
10.33945/SAMI/IJABBR.2020.2.3
Microbial
Main factor
Microbium of the lower digestive system
Intestinal microbial
Seyed Mojtaba
Fakhr Hosseini
fakhr.hosseini2000@gmail.com
1
Division Microbiology, Department of Molecular and Cell Biology, Faculty of Basic Sciences, Lahijan branch, Islamic Azad University(IAU), Lahijan, Gilan, IR. Iran
LEAD_AUTHOR
Saman
Aiubi
aiiubisaman24@hotmail.com
2
Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Arunima, A, Das, JK, Suar, M. (2019). Gut Microbes in Liver Diseases: Dietary Intervention for Promoting Hepatic Health. Dietary Interventions in Gastrointestinal Diseases. Elsevier. p: 117-31.
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Clemente, JC, Ursell, LK, Parfrey, LW, Knight, R. (2012). The impact of the gut microbiota on human health: an integrative view. Cell., 148(6):1258-1270.
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Chowdhury, R, Sahu, GK, Das, J. (1996). Stress response in pathogenic bacteria. J. Biosci., 21(2):149-160.
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Chang, CP, Hsiao, CT, Fann, WC. (2019). Risk factors associated with bacteremia correlated with mortality in patients with acute bacterial skin and skin structure infection. Intern. Emerg. Med., 14(2):259-264.
4
Chang, I, Cho, GC. (2019). Shear strength behavior and parameters of microbial gellan gum-treated soils: from sand to clay. Acta Geotechnica., 14(2):361-375.
5
Gibson, GR, Roberfroid, MB. (1995). Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. nutr., 125(6):1401-1412.
6
Huang, C, Zeng, Y, Luo, X, Ren, Z, Tang, B, Lu, Q, Gao, S, Wang, S, Mai, B. (2019). In Situ Microbial Degradation of PBDEs in Sediments from an E-Waste Site as Revealed by Positive Matrix Factorization and Compound-Specific Stable Carbon Isotope Analysis. Environ. Sci. Technol., 53(4):1928-1936.
7
Milkov, AV. (2018). Secondary microbial gas. Hydrocarbons, Oils and Lipids: Diversity, Origin, Chemistry and Fate. p: 1-10.
8
Macfarlane, S, Dillon, J. (2007). Microbial biofilms in the human gastrointestinal tract. J. Appl. Microbiol., 102(5):1187-1196.
9
Martínez, JL, Baquero, F. (2002). Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance. Clin. Microbial. Rev., 15(4):647-679.
10
Nitschke, M, Silva, SSE. (2018). Recent food applications of microbial surfactants. Crit. Rev. Food Sci. Nutr., 58(4):631-638.
11
Preininger, C, Sauer, U, Bejarano, A, Berninger, T. (2018). Concepts and applications of foliar spray for microbial inoculants. Appl. Microbiol. Biotechnol., 102(17):7265-7282.
12
Parmar, ND, Shukla, SR. (2019). Decolourization of dye wastewater by microbial methods-A review. Indian J. Chem. Technol. (IJCT)., 25(4):315-323.
13
Roberts, CA, Buikstra, JE. (2019). Bacterial infections. Ortner's Identification of Pathological Conditions in Human Skeletal Remains: Elsevier. p:321-439.
14
Toczyłowska-Mamińska, R, Szymona, K, Król, P, Gliniewicz, K, Pielech-Przybylska, K, Kloch, M, Logan, BE.(2018). Evolving microbial communities in cellulose-fed microbial fuel cell. Energies, 11(1):124.
15
Yousuf, B, Mishra, A. (2019). Exploring Human Bacterial Diversity Toward Prevention of Infectious Disease and Health Promotion. Microb. Diver. Genom. Era, p: 519-533.
16
Yeoh, YK, Chen, Z, Hui, M, Wong, MC, Ho, WC, Chin, ML, Ng, SC, Chan, FKL, Chan, PKS. (2019). Impact of inter-and intra-individual variation, sample storage and sampling fraction on human stool microbial community profiles. Peer J., 7:e6172.
17
Yeo, J, Kim, T, Jang, J, Yang, Y. (2018). Practical maximum-power extraction in single microbial fuel cell by effective delivery through power management system. Energies, 11(9):2312.
18
Verran, J, Redfern, J, Moravej, H, Adebola, Y. (2019). Refreshing the public appetite for ‘good bacteria’: menus made by microbes. J. Biol. Educat., 53(1):34-46.
19
Wang, Y, Li, L, Xiong, R, Guo, X, Liu, J. (2019). Effects of aeration on microbes and intestinal bacteria in bioaerosols from the BRT of an indoor wastewater treatment facility. Sci. Total Environ., 648:1453-1461.
20
Wu, X, Shi, Z, Zou, L, Li, CM, Qiao, Y. (2018). Pectin assisted one-pot synthesis of three dimensional porous NiO/graphene composite for enhanced bioelectrocatalysis in microbial fuel cells. J. Power Sou., 378:119-124.
21
Zhao, X, Huang, J, Lu, J, Sun, Y. (2019). Study on the influence of soil microbial community on the long-term heavy metal pollution of different land use types and depth layers in mine. Ecotoxicol. Environ. Safety, 170:218-226.
22
ORIGINAL_ARTICLE
The recent development in synthesis and pharmacological evaluation of small molecule to treat Alzheimer's diseases: A review
Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. A neurodegenerative type of dementia, the disease starts mild and gets progressively worse. Like all types of dementia, Alzheimer's is caused by brain cell death. The most common presentation marking Alzheimer's dementia is where symptoms of memory loss are the most prominent, especially in the area of learning and recalling new information.Alzheimer's disease is not simple to diagnose. There is no single test for it. For this reason, the first thing doctors do is to rule out other problems before confirming whether mental signs and symptoms are severe enough to be a kind of dementia or something else. Genetic test is possible in some settings to indicate the likelihood of someone having or developing the disease but this is controversial and not entirely reliable. There are no disease-modifying drugs available for Alzheimer's disease but some options may reduce its symptoms and help improve quality of life. A different kind of drug, memantine, an NMDA receptor antagonist, may also be used, alone or in combination with a cholinesterase inhibitor. This review highlights the several reports that attempt to design and synthesis of some classes of selective Alzheimer's disease inhibitors.
https://www.ijabbr.com/article_36889_01c80f4efee03204aea480694623f4fd.pdf
2020-06-01
134
145
10.33945/SAMI/IJABBR.2020.2.4
Alzheimer's disease
dementia
neurodegenerative disease
β-amyloid inhibitors
Masome
Rahmati
masomerahmaty0211@gmail.com
1
Department of Biology, Faculty of Basic Sciences, Islamic Azad University of central Tehran branch, Tehran, Iran
LEAD_AUTHOR
Akhter H, Huang W-T, van Groen T, Kuo H-C, Miyata T, Liu R-M. 2018. A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer’s Disease. J Alzheimers Dis 64(2):447-457.
1
Alkadhi KA, Tran TT. 2015. Chronic Stress Decreases Basal Levels of Memory-Related Signaling Molecules in Area CA1 of At-Risk (Subclinical) Model of Alzheimer’s Disease. Molecular Neurobiology 52(1):93-100.
2
Alzheimer’s A. 2015. 2015 Alzheimer's disease facts and figures. Alzheimer's & dementia: the journal of the Alzheimer's Association 11(3):332.
3
Angelucci F, Čechová K, Průša R, Hort J. 2019. Amyloid beta soluble forms and plasminogen activation system in Alzheimer’s disease: Consequences on extracellular maturation of brain‐derived neurotrophic factor and therapeutic implications. CNS Neurosci Ther 25(3):303-313.
4
Aziz O, Bürli RW, Fischer DF, Frearson J, Wall MD. 2015. Towards small molecules as therapies for alzheimer's disease and other neurodegenerative disorders. Drug Design and Discovery in Alzheimer's Disease. p 199-290.
5
Bahramikia S, Yazdanparast R, Gheysarzadeh A. 2012. Syntheses and Structure–Activity Relationships of Seven Manganese–Salen Derivatives as Anti‐amyloidogenic and Fibril‐destabilizing Agents Against Hen Egg‐white Lysozyme Aggregation. Chem Biol Drug Des 80(2):227-236.
6
Bao X, Liu G, Jiang Y, Jiang Q, Liao M, Feng R, Zhang L, Ma G, Zhang S, Chen Z. 2015. Cell adhesion molecule pathway genes are regulated by cis-regulatory SNPs and show significantly altered expression in Alzheimer's disease brains. Neurobiol Aging 36(10):2904. e2901-2904. e2907.
7
Beck MW, Oh SB, Kerr RA, Lee HJ, Kim SH, Kim S, Jang M, Ruotolo BT, Lee JY, Lim MH. 2015. A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease. Chemical Science 6(3):1879-1886.
8
Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL. 2018. Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nature chemistry:1.
9
Caruana M, Cauchi R, Vassallo N. 2016. Putative role of red wine polyphenols against brain pathology in Alzheimer’s and Parkinson’s disease. Frontiers in nutrition 3:31.
10
Castello NA, Nguyen MH, Tran JD, Cheng D, Green KN, LaFerla FM. 2014. 7,8-dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of alzheimer disease-like neuronal loss. PLoS ONE 9(3).
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Chang P-T, Talekar RS, Kung F-L, Chern T-R, Huang C-W, Ye Q-q, Yang M-Y, Yu C-W, Lai S-Y, Deore RR. 2015. A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth. Neuropharmacology 92:146-157.
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Gheysarzadeh A, Yazdanparast R. 2015. STAT5 Reactivation by Catechin Modulates H 2 O 2-Induced Apoptosis Through miR-182/FOXO1 Pathway in SK-N-MC Cells. Cell Biochem Biophys 71(2):649-656.
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Kumar A, Nisha CM, Silakari C, Sharma I, Anusha K, Gupta N, Nair P, Tripathi T, Kumar A. 2016. Current and novel therapeutic molecules and targets in Alzheimer's disease. J Formos Med Assoc 115(1):3-10.
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Lou K, Yao Y, Hoye AT, James MJ, Cornec A-S, Hyde E, Gay B, Lee VM-Y, Trojanowski JQ, Smith III AB. 2014a. Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer’s disease and related tauopathies. J Med Chem 57(14):6116-6127.
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Mao F, Yan J, Li J, Jia X, Miao H, Sun Y, Huang L, Li X. 2014b. New multi-target-directed small molecules against Alzheimer's disease: A combination of resveratrol and clioquinol. Organic and Biomolecular Chemistry 12(31):5936-5944.
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Meng F, Dai E, Yu X, Zhang Y, Chen X, Liu X, Wang S, Wang L, Jiang W. 2014. Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease. Journal of the Royal Society Interface 11(92).
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36
Yu Y, Zhang L, Li C, Sun X, Tang D, Shi G. 2014b. A Method for Evaluating the Level of Soluble β‐Amyloid (1–40/1–42) in Alzheimer’s Disease Based on the Binding of Gelsolin to β‐Amyloid Peptides. Angewandte Chemie International Edition 53(47):12832-12835.
37
Zhao H, Zhou S, Zhang M, Feng J, Wang S, Wang D, Geng Y, Wang X. 2016. An in vitro AChE inhibition assay combined with UF-HPLC-ESI-Q-TOF/MS approach for screening and characterizing of AChE inhibitors from roots of Coptis chinensis Franch. J Pharm Biomed Anal 120:235-240.
38
ORIGINAL_ARTICLE
Effect of crop residue and nitrogen levels in yield and yield attributing traits of rice under Rice-Wheat Cropping System
A 3- years (2015, 2016 and 2017) field study was carried out at National Wheat Research Program, Bhirahawa, Rupandehi, Nepal to evaluate the influence of crop residues and nitrogen levels on rice. The experiment was conducted in split plot design with three replications. Main plots were two crop residue levels (with crop residues of 30 cm wheat stubble and without crop residues) and sub plots consisted of seven nitrogen levels (0, 25, 50, 75, 100, 125 and 150 kg N ha-1). Combined analysis of three years data revealed that crop residue levels did not differ significantly in terms of grain yield; however crop residues incorporation increased the rice grain yield slightly. Significant difference was observed with application of different nitrogen levels in grain yield and yield attributing characters viz; tillers m-2, panicle length, number of filled grains per panicle and thousands grain weight. Rice grain yield was found at increasing rate with increased level of nitrogen @ 150 kg ha-1. Application of nitrogen @ 150 kg ha-1 gave highest grain yield of 4831kg ha-1 which was found at par with nitrogen @ 125 kg ha-1 with grain yield of 4722 kg ha-1. Crop residues with nitrogen @ 125 kg ha-1 resulted in 216 kg ha-1 higher rice grain yield than residues removed treatment. The overall conclusion is that an improved crop residue management with 125 kg N ha-1 increases the grain yield of rice in long run.
https://www.ijabbr.com/article_36905_20a430350789a9892c3a012574272386.pdf
2020-06-01
146
152
10.33945/SAMI/IJABBR.2020.2.5
Crop residue
Nitrogen levels
Rice
Yield
Narayan
Khatri
narayan.iaas068@gmail.com
1
1National Wheat Research Program, Bhairahawa, Rupandehi, Nepal 2Soil Science Division, Khumaltar, Nepal
LEAD_AUTHOR
Nabin
Rawal
nabin_rawal@yahoo.com
2
Soil Science Division, Khumaltar, Nepal
LEAD_AUTHOR
Devraj
Chalise
3
National Maize Research Program, Rampur, Chitwan, Nepal
LEAD_AUTHOR
Mamata
Bista
unique.mamta25@gmail.com
4
4Regional Agriculture Research Station, Lumle, Kaski, Nepal
LEAD_AUTHOR
Bisheshwor
Pandey
5
1National Wheat Research Program, Bhairahawa, Rupandehi, Nepal 2Soil Science Division, Khumaltar, Nepal
LEAD_AUTHOR
Bahrani, MJ, Kheradnam, M, Emam, Y, Ghadiri, H, Assad, MT. (2002). Effect of tillage methods on wheat yield and yield components in continuous wheat cropping. Exp. Agric., 38:389-395.
1
Cookson, WR, Beare, MH, Wilson, PE. (1998). Residue quality and management effects on microbial properties and crop residue decomposition. Appl. Soil Ecol., 7:179-188.
2
Garrido-Lestache, E, Lopez-Bellido, RJ, Lopez-Bellido, FJ. (2005). Durum wheat quality under Mediterranean conditions as affected by N rate, timing and splitting, N form and S fertilization. Eur. J. Agron., 23:265-278.
3
Gupta, RK, Singh, Y, Ladha JK, Singh, B, Singh, J, Singh, G, Pathak, H. (2007). Yield and phosphorus transformations in a rice-wheat system with crop residue and phosphorus management. Soil Sc. Soc. Am. J., 71:1500-1507.
4
Hassan, G, Khan, NU, Khan, QN. (2003). Effect of transplanting date on the yield and yield components of different rice cultivars under high temperature of D.I. Khan. Sci. Khy., 16: 129-137.
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7
Kumar, K, Goh, KM. (2000). Crop residue management: Effects on soil quality, soil nitrogen dynamics, crop yield, and nitrogen recovery. Adv. Agron., 68:197–319.
8
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Yoshida, S. (1981). Fundamentals of rice crop science. Los Baños, Philippines: IRRI.
16
ORIGINAL_ARTICLE
Alfa-Glucosidase inhibitory and antioxidant activity of hexane extract of flowers, leave and stems of Haplophyllum acutifolium DC. and Ferula haussknechtii Wolff ex Rech.
Background:α-Glucosidase Inhibition can significantly prevent glucose uptake after meal, and helps in controlling of some adverse effects in diabetics. So determination of α-Glucosidase inhibitory effect and antioxidant activity of the Haplophyllum acutifolium and Ferula haussknechtii aerial organs was the aim of this study.Methods:Inhibitory effect of hexane extracts from different organs was investigated in several concentrations at 405 nm wavelength using a microplate reader. Antioxidant activity of hexane extracts of various organs was also measured using DPPH and iron reduction tests. Results;The highest inhibitory activity of F.haussknechtii was observed at the 0.1 g/ml concentration of flower extract (100% inhibition and IC50= 0.1 μg /ml) and the most inhibitory activity of H.acutifolium, was related to the 1 g/ml concentration of flower extract (100% inhibition and IC50 = 10 μg /ml) and leaf extract (100% inhibition and IC50 = 60 μg /ml). Extract of H.acutifolium flower and leaves showed Non-competitive inhibition pattern and F.haussknechtii flower showed mixed (Competitive -Non-Competitive) inhibitory pattern at 0.001 g/ml and exhibit uncompetitive inhibitory pattern at the 0.1 g/ml. The results of antioxidant potential showed EC50 for F.haussknechtii flower and H.acutifolium leaves equalled 2.37 and 0.96 mg/ml, respectively. Conclusions:The hexane extract of the F.haussknechtii flower, and H.acutifolium flower and leaf organ have a significant inhibitory effect on the activity of α-Glucosidase, DPPH free radical scavenging activities and reducing power. So they are good resources for extraction of medicinal compounds to control blood level of glucose after meal, in diabetic patients.
https://www.ijabbr.com/article_37040_a961bb1129e0b09532a2e416598d46d3.pdf
2020-06-01
153
164
10.33945/SAMI/IJABBR.2020.2.6
Alpha-glucosidase
Ferula haussknechtii
Haplophyllum acutifolium
diabetes
Enzymatic inhibition
Mohammad
Zarei
mazarei@uok.ac.ir
1
Department of Biological sciences, Faculty of Science, University of Kurdistan, Sanandaj, IRAN
LEAD_AUTHOR
Hero
Ghafaryan
h.ghafaryan@uok.ac.ir
2
Department of Biological sciences, Faculty of Science, University of Kurdistan, Sanandaj, IRAN
AUTHOR
Ahmed, D, Kumar, V, Sharma, M, Verma, A. (2014). Target guided isolation, in-vitro antidiabetic, antioxidant activity and molecular docking studies of some flavonoids from Albizzia Lebbeck Benth. bark. BMC Complemen. Alternat. Med., 14:155-168.
1
Alam, MS, Kaur, G, Jabbar, Z, Javed, K, Athar, M. (2007). Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity. Food Chem. Toxicol., 45:910-920.
2
Bachhawat, J, Shihabudeen, M, Thirumurugan, K. (2011). Screening of fifteen Indian ayurvedic plants for alpha-glucosidase inhibitory activity and enzyme kinetics. Int. J. Pharm. Pharm. Sci., 3:267-274.
3
Basak, SS, Candan, F. (2013). Effect of Laurus nobilis L. essential oil and its main components on α-glucosidase and reactive oxygen species scavenging activity. Iran. J. pharma. Res. (IJPR), 12:367-379.
4
Becerra-Jiménez, J, Andrade-Cetto, A. (2012). Effect of Opuntia streptacantha Lem. on alpha-glucosidase activity. J. ethnopharmacol., 139:493-496.
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Bonnefont-Rousselot, D, Bastard, J, Jaudon, M, Delattre, J. (2000). Consequences of the diabetic status on the oxidant/antioxidant balance. Diabetes metabolism, 26:163-177.
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Bovicelli, P. (2007). Radical‐scavenging polyphenols: new strategies for their synthesis. J. Pharm. Pharmacol., 59:1703-1710.
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Calabrese, V, Mancuso, C, Sapienza, M, Puleo, E, Calafato, S, Cornelius, C, Finocchiaro, M, Mangiameli, A, Di Mauro, M, Stella, AMG. (2007). Oxidative stress and cellular stress response in diabetic nephropathy. Cell Stress Chaperones, 12:299-306.
8
Chang, CC, Yang, MH, Wen, HM, Chern, JC. (2002). Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J. Food Drug Anal., 10:178-182.
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Chung, YC, Chien, CT, Teng, KY, Chou, ST. (2006). Antioxidative and mutagenic properties of Zanthoxylum ailanthoides Sieb & zucc. Food Chem., 97:418-425.
10
Fatehi-Hassanabad, Z, Chan, CB, Furman, BL. (2010). Reactive oxygen species and endothelial function in diabetes. Eur. J. Pharmacol., 636:8-17.
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Fu, R, Zhang, Y, Guo, Y, Chen, F. (2014). Antioxidant and tyrosinase inhibition activities of the ethanol-insoluble fraction of water extract of Sapium sebiferum (L.) Roxb. leaves. South Afr. J. Botany, 93:98-104.
12
Giacco, F, Brownlee, M. (2010). Oxidative stress and diabetic complications. Circulat. Res., 107:1058-1070.
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Hinneburg, I, Dorman, HD, Hiltunen, R. (2006). Antioxidant activities of extracts from selected culinary herbs and spices. Food Chem., 97:122-129.
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Hünkar, T, Aktan, F, Ceylan, A, Karasu, C. (2002). Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocin‐diabetic rats. Cell Biochem. Funct., 20:297-302.
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Koo, I, Kim, S, Zhang, X. (2013). Comparative analysis of mass spectral matching-based compound identification in gas chromatography–mass spectrometry. J. chromatog. A, 1298:132-138.
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Kurzyna-Młynik, R, Oskolski, AA, Downie, SR, Kopacz, R, Wojewódzka, A, Spalik, K. (2008). Plant System. Evolut., 274:47.
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Lawag, IL, Aguinaldo, AM, Naheed, S, Mosihuzzaman, M. (2012). α-Glucosidase inhibitory activity of selected Philippine plants. J. Ethnopharmacol., 144:217-219.
18
Lebovitz, HE. (2001). Effect of the postprandial state on nontraditional risk factors. Am. J. Cardiol., 88:20-25.
19
Liu, M, Zhang, W, Wei, J, Lin, X. (2011). Synthesis and α-glucosidase inhibitory mechanisms of bis (2, 3-dibromo-4, 5-dihydroxybenzyl) ether, a potential marine bromophenol α-glucosidase inhibitor. Marine Drugs, 9:1554-1565.
20
Misbah, H, Aziz, AA, Aminudin, N. (2013). Antidiabetic and antioxidant properties of Ficus deltoidea fruit extracts and fractions. BMC Complement. Altern. Med., 13:118-130.
21
Molyneux, P. (2004). The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J. Sci. Technol., 26:211-219.
22
Pimenov, M, Leonov, M. (2004). The Asian Umbelliferae biodiversity database (ASIUM) with particular reference to South-West Asian taxa. Turkish J. Botany, 28:139-145.
23
Pistia-Brueggeman, G, Hollingsworth, RI. (2003). The use of the o-nitrophenyl group as a protecting/activating group for 2-acetamido-2-deoxyglucose. Carbohyd. Res., 338:455-458.
24
Rains, JL, Jain, SK. (2011). Oxidative stress, insulin signaling, and diabetes. Free Rad. Biol. Med., 50:567-575.
25
Semaan, D, Igoli, J, Young, L, Marrero, E, Gray, A, Rowan, E. (2017). In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw. on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes. J. Ethnopharmacol., 203:39-46.
26
Shahidi, F, Naczk, M. (1995). Food phenolics: Food Phenolics: Sources, Chemistry, Effects and Applications. Technomic Publishing Co., Lancaster..
27
Shim, YJ, Doo, HK, Ahn, SY, Kim, YS, Seong, JK, Park, IS, Min, BH. (2003). Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose. J. ethnopharmacol., 85:283-287.
28
Singh, P, Jayaramaiah, RH, Agawane, SB, Vannuruswamy, G, Korwar, AM, Anand, A, Dhaygude, VS, Shaikh, ML, Joshi, RS, Boppana, R. (2016). Potential dual role of eugenol in inhibiting advanced glycation end products in diabetes: proteomic and mechanistic insights. Sci. Report., 6:1-13.
29
Singh, VP, Bali, A, Singh, N, Jaggi, AS, (2014). Advanced glycation end products and diabetic complications. Korean J. Physiol. Pharmacol., 18:1-14.
30
Son, HU, Lee, SH. (2013). Comparison of α-glucosidase inhibition by Cudrania tricuspidata according to harvesting time, Biomed. Report., 1:624-628.
31
Staerk, D, Kesting, JR, Sairafianpour, M, Witt, M, Asili, J, Emami, SA, Jaroszewski, JW. (2009). Accelerated dereplication of crude extracts using HPLC–PDA–MS–SPE–NMR: Quinolinone alkaloids of Haplophyllum acutifolium. Phytochemistry, 70:1055-1061.
32
Yen, GC, Chen, HY. 1995). Antioxidant activity of various tea extracts in relation to their antimutagenicity. J. Agricult. Food Chem., 43:27-32.
33
Zarei, MA, Poursharifi, M. (2015). Searching for Alpha-Glucosidase Inhibitory Activity in Hexane Extracts by some Plants from Kurdistan Province. Int. J. Adv. Biol. Biomed. Res., 3:291-296.
34
ORIGINAL_ARTICLE
Study of Changes in Activity of Wheat Antioxidant Enzymes under Stress Residue of Imazethapyr Herbicide
In order to investigate physiological and biochemical changes of wheat under stress residue of Imazethapyr herbicide (Imazethapyr), an experiment was conducted in a completely randomized design with four replications in greenhouse conditions at university of Mohaghegh Ardebili. The treatments consisted of five dose levels of herbicide Imazethapyr (0, 0.011, 0.022, 0.033 and 0.044 micrograms of herbicide) per kilogram of soil. The analysis of variance showed that the content of the main and auxiliary pigments of leaf, proline, sugar content, protein, activity of catalase enzymes, peroxidase, polyphenol oxidase, root and shoot dry weight were significantly affected by herbicide. The results showed the Imazethapyr herbicide stopped the production of valine leucine and isoleucine amino acids. As a result, the rapid reduction in the volume of these amino acids led to a reduction in protein synthesis in wheat plant. Therefore, the application of doses of 0.011, 0.022, 0.033 and 0.044 micrograms of herbicides decreased 14, 26, 44 and 47 percent of leaf protein content, respectively, compared with control treatment. Further, theapplication of these doses resulted in the reduction of 2.8, 5, 27 and 64% of activity of catalase enzyme, 3.5, 39, 49 and 52% peroxidase enzyme activity and 13, 24, 35 and 46% activity of polyphenol oxidase enzyme, compared with control treatment. The results revealed that Imazethapyr herbicide activates wheat antioxidant enzymes to reduce plant tolerance from damage caused by herbicide residues; therefore, it can be used as a marker or index of herbicide damage rate in physiological research.
https://www.ijabbr.com/article_37119_25fba138650a17b60df74c23b8a0baa3.pdf
2020-06-01
165
179
10.33945/SAMI/IJABBR.2020.2.7
Carotenoid
Catalase
Peroxidase
Proline
rasoul
fakhari
rasoulfar100@gmail.com
1
1Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural resources, University of Mohaghegh Ardabili, Ardabil, Iran
LEAD_AUTHOR
ahmad
tobeh
ahmadtobeh1340@gmail.com
2
Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural resources, University of Mohaghegh Ardabili, Ardabil, Iran
AUTHOR
mohammadtaghi
alebrahim
m.t.alebrahimi@gmail.com
3
Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural resources, University of Mohaghegh Ardabili, Ardabil, Iran
AUTHOR
Mohammad
Mehdizadeh
mehdizade.mohammad@gmail.com
4
Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Iran
AUTHOR
Hossein
Karbalaei Khiavi
hossein.karbalai@yahoo.com
5
Plant Protection Research Department, Ardabil Agricultural and Natural Resources Research and Education Centre, AREEO, Ardabil, Iran
AUTHOR
Abedi, T, Pakniyat, H. (2010). Antioxidant enzyme changes in response to drought stress in ten cultivars of oilseed rape (Brassica napusL.). Czech. J. Genet. Plant., 46:27-34.
1
Apel, K, Hirt, H. (2004). Reactive Oxygen Species: Metabolism, Oxidative Stress, and Signal Transduction. Annu. Rev. Plant Biol., 55:373–399.
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Arora, A, Sairam, RK, Srivastava, GC. (2002). Oxidative stress and antioxidant system in plants. Plant Physiol., 82:1227-1237.
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Ashton, FM. (1976). Mobilization of storage proteins of seeds. Ann. Rev. Plant Physiol., 27:95-117.
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Barua, AS. (1990). Degradation of pendimethalin by soil fungi. Pest Manag. Sci., 29:419–425.
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Basantani, M, Srivastava, A, Sen, S. (2011). Elevated antioxidant response and induction of glutathione S-transferase after glyphosate treatment in Vigna radiata (L.) Wilczek. Pestic. Biochem. Physiol., 99:111–117.
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Bates, LS, Waldern, RP, Teare, ID. (1973). Rapid determination of free proline for water-stress studies. Plant Soil., 39:205-207.
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Bradford, M. (1976). A rapid and sensitivemethod for the quanititation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann. Biochem., 72:248-254.
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Cakmak, I, Horst, WJ. (1991). Effect of aluminum on lipid peroxidation, superoxide dismuatse, catalase, and peroxidase activities in root tips of soybean (Glycine max). Plant Physiol., 83:463-468.
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El-Nahas, AI. (2000). Mutagenic potential of imazethapyr herbicide (Imazethapyr®) on Viciafabain the presence of urea fertilizer. Pak. J. Biol. Sci., 3:900-905.
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ORIGINAL_ARTICLE
Effects of emamectin benzoate combined with acetamiprid, eforia and hexaflumuron against Tuta absoluta (Lep.: Gelechiidae)
Tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most destructive pests of tomato in many parts of the world including Iran. The toxicity of emamectin benzoate alone and combined with acetamiprid, eforia (thiamethoxam + lambda-cyhalotrin) and hexaflumuron was evaluated against 2nd instar larvae of Tuta absoluta (Meyrick) under 25 ± 1 °C, the relative humidity of 75 ± 5% and a photoperiod of 16:8 (L:D). Also the mixtures of tested insecticides with emamectin benzoate at LC15:LC15 ratio were evaluated on the activity of general esterase enzyme and total protein content of 2nd instar larvae. After 96 hour, emamectin benzoate had the highest toxicity (LC50 = 0.52 mg A.I./L), followed by acetamiprid (LC50 = 56.39 mg A.I./L) and eforia (LC50 = 312.01 mg A.I./L). Hexaflumuron showed no toxicity against larvae. The combination of emamectin benzoate with acetamiprid at LC50:LC50 ratio produced synergistic effects and all of the other ratios showed additive effects. The emamectin benzoate combined with either eforia or hexaflumuron at all of the ratios produced additive and antagonistic effects, respectively. Esterase activity of larvae increased when emamectin benzoate was mixed with either acetamiprid or eforia, but no significant differences were seen between emamectin benzoate alone and its mixture with hexaflumuron. The combination of emamectin benzoate with tested insecticides significantly reduced the total protein content of larvae. According to the results of this study, the mixtures of acetamiprid and eforia with emamectin benzoate showed higher negative impacts against 2nd instar larvae than emamectin benzoate alone
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mixture
esterase
Total Protein
emamectin benzoate
Tuta absoluta
mohsen
talleh
t.mhn220@gmail.com
1
Department of Plant Protection, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
LEAD_AUTHOR
Hooshang
Rafiee Dastjerdi
hooshangrafieedastjerdi@gmail.com
2
Departmant of Plant Protection, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran
AUTHOR
Bahram
Nasser
bahramnaseri@gmail.com
3
Departmant of Plant Protection, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran
AUTHOR
Aziz
Sheikhi Garjan
azizsheikhigarjan@gmail.com
4
Iranian Research Institute of Plant Protection, Tehran, Iran
AUTHOR
Khalil
Talebi Jahromi
khaliltalebijahromi@gmail.com
5
Department of Plant Protection, University of Tehran, Karaj, Iran
AUTHOR
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52
ORIGINAL_ARTICLE
Genetic Variability and Yield Performance of Sorghum
The experiment was conducted using Randomized Complete Block Design with Row Column arrangement and three replications. Grain yield, phenological and other traits were recorded. The Residual Maximum Likelihood (REML) combined analysis of variance across locations showed very highly significant (P
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10.33945/SAMI/IJABBR.2020.2.9
Early maturing
Correlation
cluster
Heritability
Spatial model
Chalacew
Endalemaw
chalachew23@gmail.com
1
Ethiopian Institute of Agricultural Research based Melkassa Agricultural Research Center, P.O Box 436, Adama, Ethiopia
LEAD_AUTHOR
Zigale
Semahegn
zigalesemahegn@gmail.com
2
Ethiopian Institute of Agricultural Research based Melkassa Agricultural Research Center, P.O Box 436, Adama, Ethiopia
AUTHOR
Abiy, L, Firew, M. (2016). Genotype X Environment Interaction and Stability of Early Maturing Sorghum [Sorghum bicolor (L.) Moench] Genotypes in Ethiopia. M.Sc. Thesis, Alemaya University of Agriculture, Ethiopia:2016-01-04T05:19:25Z.
1
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4
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Asfaw A. (2007). Assessment of Yield Stability in Sorghum. African Crop Sci. J., 15(2):83-92.
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ORIGINAL_ARTICLE
PI3K/Akt/mTOR and CDK4 combined inhibition enhanced apoptosis of thyroid cancer cell lines
Introduction Thyroid cancer is a malignant disease with poor prognosis. The PI3K/Akt/mTOR and Cyclin-Dependent Kinase 4 (CDK4) pathways are vital regulators of tumor cell proliferation and survival. Therefore the present study was designed to use dual inhibition of such pathways to kill thyroid cancer cells. Methods and materials The effects of each inhibitors on human ATC and BCPAP cell lines were evaluated by MTT assay. The suitable concentrations of inhibitors were determined and synergistic effects of such inhibitors were evaluated by bax/bcl-2 mRNA ratio, Caspase-3, and Caspase-9 activity assay as well as Akt, mTOR, and CDK4. Results:Our finding showed that both ATC and BCPAP cell proliferation is significantly inhibited by PD-332991(PD) and NVP-BEZ235 (NVP) in a time and concentration-dependent manner (P
https://www.ijabbr.com/article_37195_0e855a37795618c586a97567e37a95dc.pdf
2020-06-01
214
224
10.33945/SAMI/IJABBR.2020.2.10
Thyroid cancer
Carcinoma
Apoptosis
NVP-BEZ235
PD-332991
Neda
Hamidipour
n.hp2011@yahoo.com
1
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
AUTHOR
Mehdi
Fazeli
mfazeli@shirazu.ac.ir
2
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
LEAD_AUTHOR
Mehdi
Hedayati
hedayati47@yahoo.com
3
2. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Mohsen
Dehghani
dmohsen91@gmail.com
4
Rayan Pars Pharmacutical Industry, shiraz, Iran
AUTHOR
Razieh
Gerami
gerami777@gmail.com
5
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
AUTHOR
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