TY - JOUR ID - 12782 TI - Effect of Acyclovir on the Viability of Chicken Embryo During the Developmental Stage JO - International Journal of Advanced Biological and Biomedical Research JA - IJABBR LA - en SN - 2383-2762 AU - Mosallanejad, Seyede Saeedeh AU - Salandari, Sajedeh AU - Tavakkoli, Hadi AD - Graduate student, School of Veterinary Medicine, Shiraz University, Shiraz, Iran AD - Graduate student, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran AD - Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran Y1 - 2015 PY - 2015 VL - 3 IS - 2 SP - 179 EP - 182 KW - Acyclovir KW - Chicken KW - embryo KW - pathology DO - N2 - Objective: In recent years, antiviral drugs have been used widely in the glob to prevent and treat viral diseases. They injected into eggs to eliminate pathogens and prevent of egg transmission of disease, but the adverse effects of drugs have always been a major concern. There is little information available about the safety of antiviral drugs in the embryonated eggs of birds. The objective of this study was to evaluation of the effect of acyclovir on the viability of chicken embryo during the first trimester of the incubation period. Methods: Fertile chicken eggs were divided into two equal treatment groups. The phosphate buffered saline injected group and acyclovir-injected group whose individuals were injected with acyclovir solution at a dosage of 80 mg per Kg egg-weight. Embryos monitored daily during incubation until day 10 after which; they were examined for viability. Results: Results showed that all of the embryos were dead in the acyclovir-injected group. Based on findings, it is concluded that acyclovir at above-mentioned concentration has a severe lethal effect on the chicken embryo. So, acyclovir egg-injection cannot be used toeliminate pathogens and prevention of egg transmission of the disease UR - https://www.ijabbr.com/article_12782.html L1 - https://www.ijabbr.com/article_12782_7ae3b342d77c1706b2915d95a095b7e9.pdf ER -