Document Type: Original Article

Authors

1 Zabol university, Zabol, Iran

2 Institute of Agricultural Biotechnology, University of Zabol, Zabol, Iran

3 Kermanshah University of Medical Sciences, Martyr Chamran Hospital, Kangavar

4 Zabol Medicinal Plant Research Center, Zabol University of Medical Sciences, Zabol, Iran

Abstract

Objective: Antibiotic resistant to Antimicrobial agent is one of the most important concern in hospitals, which can cause lots of costs, treatment fails and mortality rates. Acinetobacter baumannii is a Gram-negative bacterial pathogen notorious for causing serious nosocomial infections that resist antibiotic therapy. The purpose of current study was to define the evolution of antimicrobial impact of flower extract of Hibiscus sabdariffalagainstAcinetobacterbaumannii. Methods: Hibiscus tea plant after collecting dried and then milled, their extraction was performed using vacuum from the center (Rotary). The Twelve strains of Acinetobacterbaumannii were isolated from patients in the city of Zabol. Minimum inhibitory concentrations and MBC of the extract was determined on bacteria in different concentrations by dilution in the wells. Results: The result revealed that the levels of MIC range were from 6.25 to 25ppm. The highest MIC value was 6.25 ppm against A. Baumannii and Acinetobacterbaumannii were resistance to 4 of the agent including nalidixic acid(100%), penicillin(100%), tetracyclin(58.3%), amikacin(83.3%).Discussion: In important human pathogens, drug resistance is increasing according to the results of this study may be proposed that this plant can be used as a drug. It can be a good way to replace herbs with chemical drugs.

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