Document Type : Review Article
Author
Department of Biology, Payam Noor University of Ilam, Ilam, Iran
Abstract
Background: As a dietary phytochemical, Ferulic acid (FA) is caused by metabolism between phenylalanine and tyrosine with physiological functions like anti-inflammatory, anti-diabetic, anticancer, antioxidant, antimicrobial and cardioprotective properties. This study aims to investigate FA protective effects on cardiovascular diseases.
Methods: We covered references like these, web-based scientific databases, PubMed publications, ScienceDirect and Springer. Recent patent on FA therapeutic function in treatment of cardiovascular diseases potential was evaluated.
Results: Studies showed that foods rich in FA prevent hypertension. FA, a free radical scavenger, is an enzyme inhibitor which catalyzes free radical generation and enhances scavenger enzyme activity. As a potent scavenger of free radicals, it dilutes oxidative stress, and reduces elevated blood-pressure by improving endothelial function and increasing bioavailability of this oxide in arterial vasculature. FA can enhance angiogenesis and wound healing.
Conclusion: In this review, protective function of FA, an antioxidant compound in some nutrition such as fruits, vegetables, and grains, was discussed in terms of its relationship with cardiovascular diseases. Despite numerous data on FA, its effects on human is not recognized; further clinical studies about therapeutic effects of FA on patients with vascular diseases are required.
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- Wang, S., Melnyk, J.P., Tsao, R., Marcone, M.F. 2011. Review how natural dietary antioxidants in fruits, vegetables and legumes promote vascular health. Food Research International, 44: 14–22.
- Sobhanizadeh A, Solouki M, Fazeli-Nasab B. (2017). Optimization of callus induction and effects of biological and non-biological elicitors on content of phenol/flavonoid compounds in Nigella sativa under in-vitro conditions. Journal of Cell & Tissue, 8(2): 165-184. https://doi.org/10.29252/JCT.8.2.165
- Fazeli-nasab B, Moshtaghi N, Forouzandeh M. (2019). Effect of Solvent Extraction on Phenol, Flavonoids and Antioxidant Activity of some Iranian Native Herbs. Scientific Journal of Ilam University of Medical Sciences, 27(3): 14-26 https:doi.org/10.29252/sjimu.27.3.14
- Bezerra G, Pereira M, Ostrosky E, Barbosa E, Moura M, Ferrari M, Aragão C, Gomes A. 2017. Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR. J Therm Anal Calorim, 127:1683–1691.
- Aguilar-Hernández I, Afseth NK, López-Luke T, Contreras-Torres F, Wold JP, Ornelas-Soto N. 2017. Surface enhanced Raman spectroscopy of phenolic antioxidants: a systematic evaluation of ferulic acid, p-coumaric acid, caffeic acid and sinapic acid. Vib Spectrosc, 89: 113–122.
- Barone, E., Calabrese, V., Mancuso, C. 2009. Ferulic acid and its therapeutic potential as a hormetin for age-related diseases. Biogerontology, 10: 97–108
- Poquet, L., Clifford, M.N., Williamson, G. 2008. Transport and metabolism of ferulic acid through the colonic epithelium. Drug Metab. Dispos, 36: 190–197
- Graf E. (2000). Antioxidant potential of ferulic acid. Free Rad. Biol. Med, 13:435–448.
- H. Rasouli, M. H. Farzaei, K. Mansouri, S. Mohammadzadeh and R. Khodarahmi, Plant Cell Cancer: May Natural Phenolic Compounds Prevent Onset and Development of Plant Cell Malignancy? A Literature Review, Molecules, 2016, 21, 1104.
- M. Akbari, H. Rasouli and T. Bahdor, Physiological and pharmaceutical effect of fenugreek: a review, IOSR J. Pharm., 2012, 2, 49–53.
- Jacobs D, Andersen L, Blomhoff R. (2007). Whole-grain consumption is associated with a reduced risk of noncardiovascular, noncancer death attributed to inflammatory diseases in the Iowa Women’ Health Study. Am. J. of Clin. Nutr, 85:1606–1614.
- Jayaprakasam B, Vanisree M, Zhang Y, Dewitt DL, Nair MG. (2006). Impact of alkyl esters of caffeic and FAs on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation. J. Agric. Food Chem. 54:5375–5381.
- Bezerra G, Pereira M, Ostrosky E, Barbosa E, Moura M, Ferrari M, Aragão C, Gomes A 2017). Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR. J Therm Anal Calorim, 127:1683–1691.
- Stewart, J.; Manmathan, G.; Wilkinson, P. (2017). Primary prevention of cardiovascular disease: A review of contemporary guidance and literature. JRSM Cardiovasc. Dis. 6: 2048004016687211.
- D.A. Wink, H.B. Hines, R.Y. Cheng, C.H. Switzer, W. Flores-Santana, M.P. Vitek, L.A. Ridnour, C.A. Colton. (2011). Nitric oxide and redox mechanisms in the immune response. J. Leukoc. Biol, 89:873–891.
- Chan SH, Chan JY. (2014). Brain stem NOS and ROS in neural mechanisms of hypertension. Antioxid Redox Signal, 20:146–63.
- Choi BH, Kang KS, Kwak MK. (2014). Effect of redox modulating NRF2 activators on chronic kidney disease. Molecules, 19:12727–59.
- Montezano AC, Dulak-Lis M, Tsiropoulou S, Harvey A, Briones AM, Touyz RM. (2015). Oxidative stress human hypertension: vascular mechanisms, biomarkers, and novel therapies. Can J Cardiol, 31:631–41.
- Virdis A, Bacca A, Colucci R, Duranti E, Fornai M, Materazzi G, et al. (2013). Endothelial dysfunction in small arteries of essential hypertensive patients: role of cyclooxygenase-2 in oxidative stress generation. Hypertension, 62:337–44.
- Carrizzo A, Puca A, Damato A, Marino M, Franco E, Pompeo F, et al. (2013). Resveratrol improves vascular function in patients with hypertension and dyslipidemia by modulating NO metabolism. Hypertension, 62:359–66.
- Bezerra G, Pereira M, Ostrosky E, Barbosa E, Moura M, Ferrari M, Aragão C, Gomes A. (2017). Compatibility study between ferulic acid and excipients used in cosmetic formulations by TG/DTG, DSC and FTIR. J Therm Anal Calorim, 127:1683–1691.
- Nile SH, Ko EY, Kim DH, Keum YS. (2016). Screening of ferulic acid related compounds as inhibitors of xanthine oxidase and cyclooxygenase-2 with anti-inflammatory activity. Rev Bras Farmacogn, 26:50–55.
- Alam MA. (2019). Anti-hypertensive Effect of Cereal Antioxidant Ferulic Acid and Its Mechanism of Action. Front. Nutr, 6:121. doi: 10.3389/fnut.2019.00121.
- Bumrungpert A, Lilitchan S, Tuntipopipat S, Tirawanchai N, Komindr S. (2018). Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients, 2;10(6):713. doi: 10.3390/nu10060713.
- Kwon, E.Y.; Do, G.M.; Cho, Y.Y.; Park, Y.B.; Jeon, S.M.; Choi, M.S. (2010). Anti-atherogenic property of ferulic acid in apolipoprotein E-deficient mice fed western diet: Comparison with clofibrate. Food Chem. Toxicol, 48:2298–2303.
- Lampiasi N, Montana G. (2018). An in vitro inflammation model to study the Nrf2 and NF-κB crosstalk in presence of ferulic acid as modulator. Immunobiology, 223(4-5): 349-55.19.
- Yeh C-T, Ching L-C, Yen G-C. (2009). Inducing gene expression of cardiac antioxidant enzymes by dietary phenolic acids in rats. J Nutr Biochem, 20:163–71. doi: 10.1016/j.jnutbio.2008.01.005.
- Riccioni G, Bucciarelli T, Mancini B et al. (2007). The role of the antioxidant vitamin supplementation in the prevention of cardiovascular diseases. Expert Opin Investig Drugs, 16:25–32. doi:10.1517/13543784.16.1.25.
- Wong, N.D. (2014). Epidemiological studies of CHD and the evolution of preventive cardiology. Nat. Rev. Cardiol, 11:276–289.
- Narain, J.P.; Garg, R.; Fric, A. (2011). Non-communicable diseases in the South-East Asia region: Burden, strategies and opportunities. Natl. Med. J. India, 24:280–287.
- Rajesh, Parsanathan., Sushil, K.Jain. 2020. Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases. METABOLIC SYNDROME AND RELATED DISORDERS, 18: 10-30. DOI: 10.1089/met.2019.0073
- Virdis A, Bacca A, Colucci R, Duranti E, Fornai M, Materazzi G, et al. (2013). Endothelial dysfunction in small arteries of essential hypertensive patients: role of cyclooxygenase-2 in oxidative stress generation. Hypertension, 62:337–44.
- Manrique C, Lastra G, Gardner M, Sowers JR. (2009). The renin angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress. Med Clin North Am, 93:569–82.
- Suzuki A, Yamamoto M, Jokura H et al. (2007). Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats. Am J Hypertens, 20:508– 513. doi:10.1016/j.amjhyper.2006.11.008.
- Zavoshy, R.; Noroozi, M.; Jahanihashemi, H. (2012). Effect of low calorie diet with rice bran oil on cardiovascular risk factors in hyperlipidemic patients. J. Res. Med. Sci, 17: 626–631.
- Ghosh, S.; Basak, P.; Dutta, S.; Chowdhury, S.; Sil, P.C. (2017). New insights into the ameliorative effects of ferulic acid in pathophysiological conditions. Food Chem. Toxicol, 103: 41–55.
- Bhaskaragoud, G.; Rajath, S.; Mahendra, V.; Kumar, G.S.; Krishna, A.G.; Kumar, G.S. (2016). Hypolipidemic mechanism of oryzanol components-ferulic acid and phytosterols. Biochem. Biophys. Res. Commun, 476: 82–89.
- Sahu R, Dua TK, Das S, De Feo V, Dewanjee S. (2019). Wheat phenolics suppress doxorubicin-induced cardiotoxicity via inhibition of oxidative stress, MAP kinase activation, NF-kappaB pathway, PI3K/Akt/mTOR impairment, and cardiac apoptosis. Food Chem Toxicol, 125:503–19. doi: 10.1016/j.fct.2019.01.034
- Hassan HH, Denis M, Krimbou L et al. (2006). Cellular cholesterol homeostasis in vascular endothelial cells. Can J Cardiol. 22(Suppl B):35B–40B
- Baek SE, Kim JY, Song WT, Lee SH, Hong JH, Lee CK, et al. (2014). Neuroprotective effect of rice bran extract supplemented with ferulic acid in the rat model of ischemic brain injury. Anim Cells Syst, 18:93–100. doi: 10.1080/19768354.2014.904249
- Koh PO. (2012). Ferulic acid modulates nitric oxide synthase expression in focal cerebral ischemia. Lab Anim Res, 28:273–8. doi: 10.5625/lar.2012.28.4.273
- Lin C, Chiu J, Wu I, Wang B, Pan C, Chen Y. (2010). Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1 alpha. J Nutr Biochem, 21:627–633.
- Yang G, Jiang J, Lu W. (2015). Ferulic acid exerts anti-angiogenic and anti-tumor activity by targeting fibroblast growth factor receptor 1-mediated angiogenesis. Int J Mol Sci, 16:24011–24031.
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