International Journal of Advanced Biological and Biomedical Research

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Antidiabetic, Antioxidant and Hypolipidemic potentials of Sterculia Setigera Methanol Stem Bark Extract in Alloxan-Induced Diabetic Rats

Document Type : Original Article

Authors

1 KEBBI STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY ALIERO

2 BIOCHEMISTYR, FACULTY OF LIFE SCIENCE KEBBI STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY, ALIERO, NIGERIA

3 BIOCHEMISTRY, LIFE SCIENCES, KEBBI STATE UNIVERSITY OF SCIENCE AND TECHNOLOGY, ALIERO, NIGERIA

Abstract

Background: Sterculia setigera is one of the medicinal plants used traditionally to treat various diseases with the insertion of diabetes. Diabetes mellitus is a prolonged metabolic disorder recognized as a hyperglycemia. The present study is aimed at investigating the antidiabetic activity of the methanol stem bark extract of Sterculia setigera.

Methods: LD50 screening was evaluated using standard methods. The sub-chronic effect of Sterculia setigera methanol stem bark extract on body weight, antidiabetic, antioxidant, lipid profile and histopathology were evaluated in Alloxan-induced diabetic rats respectively.

Result: Acute toxicity study of methanol stem bark extract of Sterculia setigera reveal no mortality in the animals at the limit dose of 5000mg/kg during the 14 days observation period. In the invivo study, alloxan was capable of inducing diabetic conditions as there was a significant increase (P<0.05) in the fasting blood glucose (FBG) of the entire induced groups compared to normal control. Groups treated with crude extract of Sterculia setigera (100-400mg/kg) and the standard drug (glibenclamide) showed a significant decrease (P<0.05) in FBg compared to diabetics control. There were significant reductions (P<0.05) in serum TC, TG, VLDL, LDL, CAT, SOD, GPx, Vit E, Vit A, and MDA against diabetic control. On the other hand, significant increments (P<0.05) in body weight and HDL were observed in the treated groups compared to diabetic control diabetic. Histopathological examination showed improvement in the regeneration of pancreatic β-cells islets.

Conclusion: In conclusion, Sterculia setigera stem bark extract exhibit hypoglycaemic, hypolipidemic, and antioxidant effects justifying its ethnomedicinal use for the treatment of diabetes.

Graphical Abstract

Antidiabetic, Antioxidant and Hypolipidemic potentials of Sterculia Setigera Methanol Stem Bark Extract in Alloxan-Induced Diabetic Rats

Keywords

Main Subjects

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International Journal of Advanced Biological and Biomedical Research
Volume 10, Issue 1
January 2022
Pages 84-97
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  • Receive Date: 14 January 2022
  • Revise Date: 19 February 2022
  • Accept Date: 14 March 2022
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