Document Type: Original Article

Authors

1 DVSc Student of Veterinary Theriogenology, Urmia Veterinary faculty, Urmia University, Urmia, Iran

2 Professor of Large Animal Theriogenology Department, Urmia Veterinary Faculty, Urmia University, Urmia, Iran

3 Professor of Large Animal nutrition Department, Zanjan Animal Science Faculty, Zanjan University, Zanjan, Iran

10.26655/ijabbr.2017.3.3

Abstract

Objective: Ceftiofur, a third-generation cephalosporin, is used as a usual antimicrobial drug in veterinary medicine. Positive efficiency of ceftiofur for treatment of retained fetal membrane (RFM) and acute puerperal metritis has been previously reported. Thus, this study was conducted to evaluate the efficiency of ceftiofur hydrochloride (CH) in prevention of uterine postpartum infections and improvement the fertility parameters in Holstein dairy cows. Methods: After parturition, 300 dairy cows affected with dystocia and RFM, from a single dairy herd, were randomly assigned into 2 groups (n=150). Group1 (control) was not treated but other group (CH) was subcutaneously treated with 2.2 mg/kg CH for 5 days. Results: CH could significantly reduce rate of uterine infections compared with control groups (P<0.01). Open days and first service rate were significantly lower in CH group compared with control group (P<0.01). It can be concluded that uterine infections and metritis are inevitable part of dairy cow transitional period. Injection of CH had beneficial effects on reduction the infections and thus it can be advised use of CH to reduce infections and increasing fertility rate in dairy cows affected with RFM and dystocia, before other control program.

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Brown, S. A., S. T. Chester, A. K. Speedy, V. L. Hubbard, J. K. Callahan, P. J. Hamlow, B. Hibbard, and E. J. Robb. 2000. Comparison of plasma pharmacokinetics and bioequivalence of ceftiofur sodium in cattle after a single intramuscular or subcutaneous injection. J. Vet. Pharmacol. Ther. 23:273–280.

Brown, S. A., P. S. Jaglan, and A. Banting. 1991. Ceftiofur sodium: Disposition, protein-binding, metabolism, and residue depletion profile in various species. Acta Vet. Scand. Suppl. 87:97–99.

Drillich, M., M. Mahlstedt, U. Reichert, B. A. Tenhagen, and W. Heuwieser. 2006a. Strategies to improve the therapy of retained fetal membranes in dairy cows. J. Dairy Sci. 89:1502–1508.

Drillich, M., S. Arlt, S. Kerting, A. A. Bergwerff, P. Scherpenisse, and W. Heuwieser. 2006b. Ceftiofur derivates in serum, uterine tissues, cotyledons, and lochia after fetal membrane retention. J. Dairy Sci. 89:3431–3438.

Drillich, M., O. Beetz, A. Pfutzner, M. Sabin, H. J. Sabin, P. Kutzer, H. Nattermann, and W. Heuwieser. 2001. Evaluation of a systemic antibiotic treatment of toxic puerperal metritis in dairy cows. J. Dairy Sci. 84:2010–2017.

Galvao, K. N., L. F. Greco, J. M. Vilela, M. F. Sa Filho, and J. E. P. Santos. 2009. Effect of intrauterine infusion of ceftiofur on uterine health and fertility in dairy cows. J. Dairy Sci. 92:1532–1542.

Gilbert, R. O., S. T. Shin, C. L. Guard, H. N. Erb, and M. Frajblat. 2005. Prevalence of endometritis and its effects on reproductive performance of dairy cows. Theriogenology 64:1879–1888.

Haggett, E. F., and W. D. Wilson. 2008. Overview of the use of antimicrobials for treatment of bacterial infections in horses. Equine Vet. Educ. 20:433–448.

Hornish, R. E., and S. F. Kotarski. 2002. Cephalosporins in veterinary medicine – Ceftiofur use in food animals. Curr. Top. Med. Chem. 2:717–731.

Lima, F. S., and A.viera-neto.2014. Efficacy of Ampiciline trihydrate or ceftiofur hydrochloride for treatment of metritis and subsequent fertility in dairy cows.J. Dairy Sci. 97: 5401–5414.

Okker, H., E. J. Schmitt, P. L. A. M. Vos, P. Scherpenisse, A. A. Bergwerff, and F. H. Jonker. 2002. Pharmacokinetics of ceftiofur in plasma and uterine secretions and tissues after subcutaneous postpartum administration in lactating dairy cows. J. Vet. Pharmacol. Ther. 25:33–38.

Olfati A, Moradi kor N. Busulfan and Functions in the Mammalian Spermatogenesis. Austin Andro 2016; 1(2): 10-11.

Olfati A, Moghaddam GH, Moradi kor N, Baradaran B. The relationship between trace mineral concentrations of amniotic fluid with placenta traits in the pregnancy toxemia Ghezel ewes. Asian Pacific J Reprod 2016; 5 (4); 321-325.

Paisley, L. G., W. D. Mickelsen, and P. B. Anderson. 1986. Mechanisms and therapy for retained fetal membranes and uterine infections of cows: A review. Theriogenology 25:353–381.

Salmon, S. A., J. L. Watts, and R. J. Yancey. 1996. In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance. J. Vet. Diagn. Invest. 8:332–336.

Sheldon, I. M., and H. Dobson. 2004. Postpartum uterine health in cattle. Anim. Reprod. Sci. 82–83:295–306.

Sheldon, I. M., G. S. Lewis, S. LeBlanc, and R. O. Gilbert. 2006. Defining postpartum uterine disease in cattle. Theriogenology 65:1516–1530.

Smith, B. I., G. A. Donovan, C. Risco, R. Littell, C. Young, L. H. Stanker, and J. Elliott. 1998. Comparison of various antibiotic treatments for cows diagnosed with toxic puerperal metritis. J. Dairy Sci. 81:1555–1562.