Document Type: Review Article

Authors

1 Department of basic science, Faculty of veterinary medicine, Islamic Azad Branch, Univeristy of Shushtar, Khuzestan-Iran

2 2Department of basic science, Faculty of veterinary medicine, University of Tabriz, Tabriz-Iran

3 Department of basic science, veterinary medicine faculty, Shushtar university, Khuzestan-Iran

10.33945/SAMI/IJABBR.2019.3.8

Abstract

Cigarette smoking is growing and nicotine is considered as the most adverse agent in the cigarette smoking. Nicotine is an alkaloid and forms 90% of alkaloids of cigarette. Nicotine is accountable for creating disorders and cancers such as lung cancer, heart disease and chronic lung disease. Nicotine can be considered as an autophagy and apoptosis inducer which can either directly or indirectly stimulate apoptosis and autophagy. Apoptosis is the programmed cell death and oxidative stress in the most known inducer of apoptosis. However, physicochemical stresses, free radicals and removing of nutrients are other factors which induce apoptosis. Autophagy plays the role of recycling which mainly attacks damaged and aged cells and organelles. In this review, we investigate the effect of nicotine on these pathways.

Keywords

Main Subjects

Abdollahzadeh Soreshjani, S, Ashrafizadeh, M. (2018a). Effects of exercise on testosterone level, heat shock protein, and fertility potential. Reviews Clin. Med., 5(4):141-145.

Abdollahzadeh Soreshjani, S, Ashrafizadeh, M. (2018b). The Effects of the Exercise on the Testosterone Level, Heat Shock Proteins and Fertility Potential. Reviews Clin. Med., 5(4):12-15.

Ahmadi, Z, Ashrafizadeh, M. (2018). Downregulation of osteocalcin gene in chickens treated with Lead Acetate II. Int. Biolog. Biomed. J., 4(4):0-0.

Ahmadi, Z, & Ashrafizadeh, M. (2019). Down Regulation of Osteocalcin Gene in Chickens Treated with Cadmium. Iranian J. Toxicol., 13(1):1-4.

Ahmadi, Z, Mohammadinejad, R, Ashrafizadeh, M. (2019). Drug delivery systems for resveratrol, a non-flavonoid polyphenol: Emerging evidence in last decades. J. Drug Delivery Sci. Technol.

Amini, K, Zhaleh, H, Tahvilian, R, Farnia, V. (2019). Low concentration of morphine protects against cell death, oxidative stress and calcium accumulation by nicotine in PC12 cells. Bratisl. Lek. listy, 120(4):256-262.

Ashkenazi, A, Dixit, VM. (1998). Death receptors: signaling and modulation. science, 281(5381):1305-1308.

Ashrafizadeh, M, Ahmadi, Z. (2019). The effects of astaxanthin treatment on the sperm quality of mice treated with nicotine. Reviews in Clinical Medicine, 6(1):156-158.

Ashrafizadeh, M, Mohammadinejad, R, Tavakol, S, Ahmadi, Z, Roomiani, S, Katebi, M. Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy. Journal of Cellular Physiology.

Ashrafizadeh, M, Rafiei, H, Ahmadi, Z. (2018). Histological changes in the liver and biochemical parameters of chickens treated with lead acetate II. Iranian J. Toxicol., 12(6):1-5.

Birnbaum, M, Clem, R, Miller, L. (1994). An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. J. virol., 68(4):2521-2528.

Black, RA, Kronheim, SR, Sleath, PR. (1989). Activation of interleukin‐1β by a co‐induced protease. FEBS lett., 247(2):386-390.

Bodas, M, Van Westphal, C, Carpenter-Thompson, R, Mohanty, DK, Vij, N. (2016). Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment. Free Radic. Biol. Med., 97:441-453.

Cheng, SF, Qin, XS, Han, ZL, Sun, XF, Feng, YN, Yang, F, . . . De Felici, M. (2018). Nicotine exposure impairs germ cell development in human fetal ovaries cultured in vitro. Aging (Albany NY), 10(7):1556.

Chicheportiche, Y, Bourdon, PR, Xu, H, Hsu, YM, Scott, H, Hession, C, Garcia, I, Browning, JL. (1997). TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J. Biol. Chem., 272(51):32401-32410.

Chinnaiyan, AM. (1999). The apoptosome: heart and soul of the cell death machine. Neoplasia, 1(1):5-15.

Chuang, SM, Wang, IC, Yang, JL. (2000). Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis, 21(7):1423-1432.

Elmore, S. (2007). Apoptosis: a review of programmed cell death. Toxicol. Pathol., 35(4):495-516.

Fatemeh Hassanzadeh Davarania , M. A., Roohollah Saberi Risehc , Elham Ghasemipour Afshard , Hamid Mohammadie , Seyed Hamid Razavif , Ali Mandegaryg, Reza Mohammadinejadh*. (2018). Antifungal nanoparticles reduce aflatoxin contamination in pistachio. Pistachio and Health journal.

Fink, SL, Cookson, BT. (2005). Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect. Immune., 73(4):1907-1916.

Hassanzadeh Davarani, F, Ashrafizadeh, M, Saberi Riseh, R, Ghasemipour Afshar, E, Mohammadi, H, Razavi, SH, Mandegary A, Mohammadinejad, R. (2018). Antifungal nanoparticles reduce aflatoxin contamination in pistachio. Pistachio Health J., 1(2):26-33. doi:10.22123/phj.2018.130469.1007

Hill, MM, Adrain, C, Duriez, PJ, Creagh, EM, Martin, SJ. (2004). Analysis of the composition, assembly kinetics and activity of native Apaf‐1 apoptosomes. EMBO J., 23(10):2134-2145.

Jayakiran, M. (2015). Apoptosis-biochemistry: a mini review. J. Clin. Exp. Pathol., 5(1):1-4.

Kalariya, NM, Wills, NK, Ramana, KV, Srivastava, SK, van Kuijk, FJ. (2009). Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway. Exp. Eye Res., 89(4):494-502.

Kang, SW, Park, HJ, Ban, JY, Chung, JH, Chun, GS, Cho, JO. (2011). Effects of nicotine on apoptosis in human gingival fibroblasts. Arch. Oral Boil., 56(10):1091-1097.

Kerr, JFR. (1965). A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes. J. pathol. Bacterial., 90(2):419-435.

Kim, KH, Joo, KJ, Park, HJ, Kwon, CH, Jang, MH, Kim, CJ. (2005). Nicotine induces apoptosis in TM3 mouse Leydig cells. Fertil. Steril., 83(4):1093-1099.

Komatsu, M, Waguri, S, Ueno, T, Iwata, J, Murata, S, Tanida, I, . . . Uchiyama, Y. (2005). Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell. Biol., 169(3):425-434.

Lee, HJ, Lee, J, Min, SK, Guo, HY, Lee, SK, Kim, HR, . . . Lee, SK. (2008). Differential induction of heme oxygenase‐1 against nicotine‐induced cytotoxicity via the PI3K, MAPK, and NF‐kappa B pathways in immortalized and malignant human oral keratinocytes. J. Oral Pathol. Med., 37(5):278-286.

Lee, YS, Yoon, HJ, Oh, JH, Park, HJ, Lee, EH, Song, CW, Yoon, S. (2009). 1,3-Dinitrobenzene induces apoptosis in TM4 mouse Sertoli cells: Involvement of the c-Jun N-terminal kinase (JNK) MAPK pathway. Toxicol. Lett., 189(2):145-151.

Liu, S, Sun, Y, Li, Z. (2018). Resveratrol protects Leydig cells from nicotine‐induced oxidative damage through enhanced autophagy. Clin. Exp. Pharmacol. Physiol., 45(6):573-580.

LIU, Y. (2004). Damaging effect of cigarette smoke extract on primary cultured human umbilical vein endothelial cells and its mechanism. Biomed. Environ. Sci., 17:121-134.

Lockshin, RA, Zakeri, Z. (2001). Programmed cell death and apoptosis: origins of the theory. Nat. Rev. Mol. Cell Boil., 2(7):545.

Locksley, RM, Killeen, N, Lenardo, MJ. (2001). The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell, 104(4):487-501.

Marinucci, L, Balloni, S, Fettucciari, K, Bodo, M, Talesa, VN, Antognelli, C. (2018). Nicotine induces apoptosis in human osteoblasts via a novel mechanism driven by H2O2 and entailing Glyoxalase 1-dependent MG-H1 accumulation leading to TG2-mediated NF-kB desensitization: Implication for smokers-related osteoporosis. Free Radical Biol. Med., 117:6-17.

Mohammadghasemi, F, Jahromi, SK. (2018). Melatonin ameliorates testicular damages induced by nicotine in mice. Iranian J. Basic Med. Sci., 21(6):639.

Mohammadinejad, R, Ahmadi, Z, Tavakol, S, Ashrafizadeh, M. (2019). Berberine as a potential autophagy modulator. Journal of Cellular Physiology.

Mohammadinejad, R, Dadashzadeh, A, Moghassemi, S, Ashrafizadeh, M, Dehshahri, A, Pardakhty, A., . . . Mandegary, A. (2019). Shedding light on gene therapy: carbon dots for the minimally invasive image-guided delivery of plasmids and noncoding RNAs. Journal of advanced research.

Peter, ME, Krammer, PH. (1998). Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis. Curr. Opin. Immunol., 10(5):545-551.

Platanias, LC. (2003). The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacol. Ther., 98(2), 129-142.

Portt, L, Norman, G, Clapp, C, Greenwood, M, Greenwood, MT. (2011). Anti-apoptosis and cell survival: a review. Biochim. Biophys. Acta (BBA)-Mol. Cell Res., 1813(1):238-259.

Rafiei, H, Ahmadi, Z, Ashrafizadeh, M. (2018a). Effects of orally administered lead acetate II on rat femur histology, mineralization properties and expression of osteocalcin gene. Int. Biolog. Biomed. J., 4(3):149-155.

Rafiei, H., Ahmadi, Z., & Ashrafizadeh, M. (2018b). Effects of Orally Administered Lead acetate II on Rat Femur Histology, Mineralization Properties and Expression of Osteocalcin Gene. Int. Biolog. Biomed. J., 4(3):0-0.

Rafiei, H, Ashrafizadeh, M. (2018). Expression of collagen type II and osteocalcin genes in mesenchymal stem cells from rats treated with lead acetate II. Iranian J. Toxicol., 12(5):35-40.

Rubio-Moscardo, F, Blesa, D, Mestre, C, Siebert, R, Balasas, T, Benito, A., . . . Schilhabel, M. (2005). Characterization of 8p21. 3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood, 106(9), 3214-3222.

Sobhani, B, Roomiani, S, Ahmadi, Z, Ashrafizadeh, M. (2019). Histopathological Analysis of Testis: Effects of Astaxanthin Treatment against Nicotine Toxicity. Iranian J. Toxicol., 13(1):41-44.

Suliman, A, Lam, A, Datta, R, Srivastava, RK. (2001). Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and-independent pathways. Oncogene, 20(17):2122.

Tian, D, Zhu, M, Li, J, Ma, Y, Wu, R. (2009). Cigarette smoke extract induces activation of β-catenin/TCF signaling through inhibiting GSK3β in human alveolar epithelial cell line. Toxicol. Lett., 187(1):58-62.

Toivola, D, Strnad, P, Habtezion, A, Omary, M. (2010). Intermediate filaments take the heat as stress proteins. Trend. cell boil., 20(2):79-91.

Tsukada, M, Ohsumi, Y. (1993). Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae. FEBS lett., 333(1-2):169-174.

Wang, YF, Sun, XF, Han, ZL, Li, L, Ge, W, Zhao, Y, De Felici, M, Shen, W, Cheng, SF. (2018). Protective effects of melatonin against nicotine-induced disorder of mouse early folliculogenesis. Aging (Albany NY), 10(3):463.

Wang, Z, Liu, B, Zhu, J, Wang, D, Wang, Y. (2019). Nicotine-mediated autophagy of vascular smooth muscle cell accelerates atherosclerosis via nAChRs/ROS/NF-κB signaling pathway. Atherosclerosis, 284:1-10.

Wei, Y, Pattingre, S, Sinha, S, Bassik, M, Levine, B. (2008). JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol. Cell, 30(6):678-688.

Wyllie, AH. (2010). “Where, O death, is thy sting?” A brief review of apoptosis biology. Mol. Neurobiol., 42(1):4-9.

Xiao, X, Shang, X, Zhai, B, Zhang, H, Zhang, T. (2018). Nicotine alleviates chronic stress-induced anxiety and depressive-like behavior and hippocampal neuropathology via regulating autophagy signaling. Neurochem. Int., 114:58-70.

Yang, Q, Jhanji, V, Tan, SQ, Chan, KP, Cao, D, Chu, WK, Zhang, M, Pang, CP, Ng, TK. (2019). Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration. J. Cell. Biochem., 120(3):4203-4213.

Zanetti, F, Giacomello, M, Donati, Y, Carnesecchi, S, Frieden, M, Barazzone-Argiroffo, C. (2014). Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells. Free Radic. Biol. Med., 76:173-184.