Document Type: Review Article

Authors

Department of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan,Iran.

10.33945/SAMI/IJABBR.2020.2.1

Abstract

Histamine is synthesized via histidine decarboxylase (HDC) in wide types of immune cells and is involved in abundant physiologic and pathologic processes. Histamine is a mediator released during inflammatory reactions, such as food allergy. Food allergy is immunological reactions to 'fight off' specific allergens within food in susceptible individuals. The aim of this study is investigation of the histamine hemostasis and food allergy to discover the relationship between them.
Analysis of data from multiple electronic databases such as Scopus, PubMed, Google Scholar and Science Direct were performed. Various criteria were applied to select the articles for inclusion.
Food allergy reaction is divided to 4 types of the immune response. These reactions with different mechanisms cause increased concentrations of histamine. Histamine does various action in different tissue.
The correct and timely diagnosis of food allergy can lead to reduction of the chemicals release and inhibit of abnormal reaction of the body. According to some studies, Measurement of N-methylhistamine (NMH) as the major metabolite of histamine may help to diagnose patients with food-allergen induced clinical symptoms.

Keywords

Anagnostou, K, Meyer, R, Fox, A, Shah, N. (2015). The rapidly changing world of food allergy in children. F1000Prime Rep., 7:35.

Backhaus, B, Raithel, M, Hahn, E. (2005). Nicht-immunologisch induzierte Histaminfreisetzung an vitalen menschlichen Darmschleimhautbiopsien durch Stimulation mit Polyaminen. Allergo J., 14:41.

Bakker, RA, Schoonus, SB, Smit, MJ, Timmerman, H, Leurs, R. (2001). Histamine H1-receptor activation of nuclear factor-κB: roles for Gβγ-and Gαq/11-subunits in constitutive and agonist-mediated signaling. Mol. Pharmacol., 60(5):1133-1142.

Bäumer, W, Wendorff, S, Gutzmer, R, Werfel, T, Dijkstra, D, Chazot, P, Stark, H, Kietzmann, M. (2008). Histamine H4 receptors modulate dendritic cell migration through skin–immunomodulatory role of histamine. Allergy, 63(10):1387-1394.

Berin, MC, Sampson, HA. (2013). Food allergy: an enigmatic epidemic. Trend. Immunol., 34(8):390-397.

Bhowmik, M, Khanam, R, Vohora, D. (2012). Histamine H3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives. Br. J. Pharmacol., 167(7):1398-1414.

Boyce, JA, Assa'ad, A, Burks, AW, Jones, SM, Sampson, HA, Wood, RA, Plaut, M, Cooper, SF, Fenton, MJ, Arshad, SH, Bahna, SL, Beck, LA, Byrd-Bredbenner, C, Camargo, CA, Eichenfield, L, Furuta, GT, Hanifin, JM, Jones, C, Schwaninger, JM. (2011). Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. J. Am. Academy Dermatol., 64(1):175-192.

Coruzzi, G, Adami, M. (2008). Peripheral actions and therapeutic potential in periphery. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders. Boca Raton, CRC Press Taylor & Francis, p. 167-209.

Coruzzi, G, Adami, M, Pozzoli, C. (2012). Role of histamine H4 receptors in the gastrointestinal tract. Front Biosci (Schol Ed), 4:226-239.

De Benedetto, A, Yoshida, T, Fridy, S, Park, JE, Kuo, IH, Beck, LA. (2015). Histamine and skin barrier: are histamine antagonists useful for the prevention or treatment of atopic dermatitis? J. Clin. Med., 4(4):741-755.

Del Valle, J, Gantz, I. (1997). Novel insights into histamine H2receptor biology. Am. J. Phys. Gastroint. Liver Physiol., 273(5):G987-G996.

Griffiths, C. E. M., & Barker, R. D. R. (2004). Psoriasis. In: Rook-W. Wilkinsum Ebling. Text book of dermatology, Last ed. Blackwell Science.

Gutowska‐Owsiak, D, Greenwald, L, Watson, C, Selvakumar, TA, Wang, X, Ogg, GS. (2014). The histamine‐synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin. Br. J. Dermatol., 171(4):771-778.

Gutzmer, R, Gschwandtner, M, Rossbach, K, Mommert, S, Werfel, T, Kietzmann, M, Baeumer, W. (2011). Pathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus. Front Biosci (Schol Ed), 3:985-994.

Hanuskova, E, Plevkova, J. (2013). The role of histamine H4 receptors as a potential targets in allergic rhinitis and asthma. Open J. Mol. Integrat. Physiol., 3(01):6.

Ho, MHK, Wong, WHS, Chang, C. (2014). Clinical spectrum of food allergies: a comprehensive review. Clin. Rev. Allergy  Immunol., 46(3):225-240.

Horr, B, Borck, H, Thurmond, R, Grösch, S, Diel, F. (2006). STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes. Int. immunopharmacol., 6(10):1577-1585.

Jemima, EA, Prema, A, Thangam, EB. (2014). Functional characterization of histamine H4 receptor on human mast cells. Mol. Immunol., 62(1):19-28.

Jutel, M, Akdis, M, Akdis, C. (2009). Histamine, histamine receptors and their role in immune pathology. Clin. Experiment. Allergy, 39(12):1786-1800.

Kumar, S, Verma, AK, Das, M, Dwivedi, PD. (2012). Molecular mechanisms of IgE mediated food allergy. Int. immunopharmacol., 13(4):432-439.

 

Leurs, R, Bakker, RA, Timmerman, H, de Esch, IJ. (2005). The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat. Rev. Drug Discov., 4(2):107-120.

Leurs, R, Vische, HF, Wijtman, M, de Esc, IJ. (2011). En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family. Trend.  Pharmacol. Sci., 32(4):250-257.

Lim, HD, van Rijn, RM, Ling, P, Bakker, RA, Thurmond, RL, Leurs, R. (2005). Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J. Pharmacol. Exper. Therapeut., 314(3):1310-1321.

Maintz, L, Novak, N. (2007). Histamine and histamine intolerance. Am. J. Clin. Nutrit., 85(5):1185-1196.

Novak, N, Kraft, S, Bieber, T. (2001). IgE receptors. Curr. Opin. Immunol., 13(6):721-726.

Parrish, C. P., Kim, E. H., & Bird, J. A. (2018). Interventional Therapies for the Treatment of Food Allergy. Immunology and allergy clinics of North America, 38(1), 77-88.

Raithel, M, Küfner, M, Ulrich, P, Hahn, EG. (1999). The involvement of the histamine degradation pathway by diamine oxidase in manifest gastrointestinal allergies. Inflammat. Res., 48(13):75-76.

Schwelberger, HG. (2004). Histamine N-methyltransferase (HNMT) enzyme and gene. Histamine: biology and medical aspects. Budapest, Hungary: SpringMed Publishing, p. 53-9.

Schwelberger, HG. (2004). Diamine oxidase (DAO) enzyme and gene. Histamine: biology and medical aspects. Budapest, Hungary: SpringMed Publishing, p. 43-52.

Stone, KD, Prussin, C, Metcalfe, DD. (2010). IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol., 125(2):S73-S80.

Verhoeckx, KCM, Vissers, YM, Baumert, JL, Faludi, R, Feys, M, Flanagan, S, Herouet-Guicheney, C, Holzhauser, T, Shimojo, R, van der Bolt, N, Wichers, H, Kimber, I. (2015). Food processing and allergenicity. Food Chem. Toxicol., 80:223-240.

Yanai, K, Tashiro, M. (2007). The physiological and pathophysiological roles of neuronal histamine: an insight from human positron emission tomography studies. Pharmacol. Therapeut., 113(1):1-15.

Żukiewicz-Sobczak, WA, Wróblewska,P, Adamczuk, P, Causes, PK. (2013). symptoms and prevention of food allergy. Advances in Dermatology and Allergology, Postepy. Dermatol. Alergol., 30(2):113.