Document Type: Original Article


1 Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh

2 Grain Quality and Nutrition (GQN) Division, Bangladesh Rice Research Institute (BRRI), Gazipur, Bangladesh



Background: Hypercholesterolemia led cardiovascular disease (CVD) complications are plaguing the globe. In the present study,Bangladesh Rice Research Institute (BRRI) high yield variety (HYV) rice named as BR5 was selected for extracting bran oil followed by fatty acid analysis and in vivo hypocholesterolemic effect of the extracted rice bran oil (RBO) for the sake of ameliorating CVD.
Method: RBO was extracted using n-Hexane followed by fatty acid analysis and anti-hypocholesterolemic study on rats against soybean oil (SBO), mustard oil (MBO) and butter oil (BTO) followed by organ function tests. Study period was four weeks. Then the rats were killed, their blood was collected and serum biochemical parameters were analyzed using semi-auto analyzer.
Results: Fattyacid analyses revealed BR5 was the best among the six HYVs of rice. Compared with the other edible oils, RBO derived from BR5 showed significantly increasing effect upon plasma total cholesterol and low density lipoprotein cholesterol lowering while high density lipoprotein cholesterol increasing. Toxicological studies showed no detrimental effect of BR5 derived RBO on cardiac, renal and hepatic functions.
Conclusion: BR5 is a rich source of RBO that provides balanced fatty acid support and exerts hypocholesterolemic effects without any detectable side effects. Consumption of BR5 derived RBO would aid in CVD amelioration.


Main Subjects

1. Pan X F, Li Y, Franco O H, Yuan J M, Pan A, Koh W P. (2019). Impact of combined lifestyle factors on all-cause and cause-specific mortality and life expectancy in Chinese: the Singapore Chinese Health Study. J Gerontol A Biol Sci Med Sci.

2. Hansen D, Niebauer J, Cornelissen V, Barna O, Neunhäuserer D, Stettler C, Tonoli C, Greco E, Fagard R, Coninx K, Vanhees L, Piepoli M F, Pedretti R, Ruiz G R, Corrà U, Schmid J P, Davos C H, Edelmann F, Abreu A, Rauch B, Ambrosetti M, Braga S S, Beckers P, Bussotti M, Faggiano P, Garcia-Porrero E, Kouidi E, Lamotte M, Reibis R, Spruit M A, Takken T, Vigorito C, Völler H, Doherty P, Dendale P. (2018). Exercise Prescription in Patients with Different Combinations of Cardiovascular Disease Risk Factors: A Consensus Statement from the EXPERT Working Group. Sports Med, 48(8): 1781-1797.

3. Hartley L, Mavrodaris A, Flowers N, Ernst E, Rees K. (2017). WITHDRAWN: Transcendental meditation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev, 11(11): CD010359.

4. Davari A, Solouki M, Fazeli-Nasab B. (2018). Effects of jasmonic acid and titanium dioxide nanoparticles on process of changes of phytochemical and antioxidant in genotypes of Satureja hortensis L. Eco-Phytochemical Journal of Medicinal Plants, 5(4): 1-20 (In Persian).

5. Sharifi-Rad J, Rodrigues C F, Sharopov F, Docea A O, Can Karaca A, Sharifi-Rad M, Kahveci Karıncaoglu D, Gülseren G, Şenol E, Demircan E, Taheri Y, Suleria H A R, Özçelik B, Nur Kasapoğlu K, Gültekin-Özgüven M, Daşkaya-Dikmen C, Cho W C, Martins N, Calina D. (2020). Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds. Int J Environ Res Public Health, 17(7).

6. Salehi B, Del Prado-Audelo M L, Cortés H, Leyva-Gómez G, Stojanović-Radić Z, Singh Y D, Patra J K, Das G, Martins N, Martorell M, Sharifi-Rad M, Cho W C, Sharifi-Rad J. (2020). Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases. J Clin Med, 9(3).

7. Ali M A, Islam M A, Othman N H, Noor A M, Hossen J, Ibrahim M. (2019). Effect of Heating on Compositional Characteristics and Oxidative Stability of Crude and Refined Rice Bran Oil. J Oleo Sci, 68(11): 1085-1097.

8. Kobayashi E, Ito J, Kato S, Sawada K, Matsuki M, Hashimoto H, Miyazawa T, Nakagawa K. (2016). Presence of orally administered rice bran oil γ-oryzanol in its intact form in mouse plasma. Food Funct, 7(12): 4816-4822.

9. Sohail M, Rakha A, Butt M S, Iqbal M J, Rashid S. (2017). Rice bran nutraceutics: A comprehensive review. Crit Rev Food Sci Nutr, 57(17): 3771-3780.

10. Rahman M, Zaman M, Islam A S. (2011). Prospect of rice bran oil production in Bangladesh. J Agril Engg, 39(1): 1-8.

11. Deshpande A B, Chidley H G, Oak P S, Pujari K H, Giri A P, Gupta V S. (2016). Data on changes in the fatty acid composition during fruit development and ripening of three mango cultivars (Alphonso, Pairi and Kent) varying in lactone content. Data in brief, 9: 480-491.

12. Sugano M, Tsuji E. (1997). Rice bran oil and cholesterol metabolism. J Nutr, 127(3): 521S-524S.

13. Al-Okbi S Y, Mohamed D A, Hamed T E, Al-Siedy E S. (2019). Rice bran as source of nutraceuticals for management of cardiovascular diseases, cardio-renal syndrome and hepatic cancer. Journal of Herbmed Pharmacology, 9(1): 68-74.

14. Lei L, Chen J, Liu Y, Wang L, Zhao G, Chen Z Y. (2018). Dietary Wheat Bran Oil Is Equally as Effective as Rice Bran Oil in Reducing Plasma Cholesterol. J Agric Food Chem, 66(11): 2765-2774.

15. Sunitha T, Manorama R, Rukmini C. (1997). Lipid profile of rats fed blends of rice bran oil in combination with sunflower and safflower oil. Plant Foods Hum Nutr, 51(3): 219-230.

16. Khanna A K, Rizvi F, Chander R. (2002). Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. J Ethnopharmacol, 82(1): 19-22.

17. Devi R, Sharma D K. (2004). Hypolipidemic effect of different extracts of Clerodendron colebrookianum Walp in normal and high-fat diet fed rats. J Ethnopharmacol, 90(1): 63-68.

18. Anila L, Vijayalakshmi N R. (2002). Flavonoids from Emblica officinalis and Mangifera indica-effectiveness for dyslipidemia. J Ethnopharmacol, 79(1): 81-87. 10.1016/s0378-8741(01)00361-0

19. Araghi A, Seifi S, Sayrafi R, Sadighara P. (2016). Safety assessment of rice bran oil in a chicken embryo model. Avicenna J Phytomed, 6(3): 351-356.

20. Shimomura Y, Kobayashi I, Maruto S, Ohshima K, Mori M, Kamio N, Fukuda H. (1980). Effect of gamma-oryzanol on serum TSH concentrations in primary hypothyroidism. Endocrinol Jpn, 27(1): 83-86.