Effect of famotidine (histamine H2-receptor antagonist) on food and water intake in broiler chickens in a state of hunger and satiety

Document Type: Original Article


1 Department of Animal Science, Ilam University, Ilam, Iran

2 Department of Animal Science, Faculty of Agriculture, Islamic Azad University, Ilam Branch, Ilam, Iran

3 Faculty of Para Veterinary Medicine, Ilam University, Ilam, Iran


The role of histamine in the regulation of food and water intake in mammals and birds of the review, this study evaluated the effects of intraperitoneal administration of famotidine as histamine H2 -receptor antagonist, in broiler chicks on feed intake and satiety in water and was hungry. 32 male Ross broiler chicks reared in groups of four weeks, 16 samples (control and test ) were then injected with 0.5 ml famotidine ( level 2.5 mg per kg of body weight ) intraperitoneally , taking feed and water the chickens at intervals of 15 , 30, 45, 60, 90min and 2 , 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 21, 23h after injection the control group was weighed and recorded .Results showed that famotidine injection in chicks fed at 30 , 45, 60, 120, 1260 and 1380 min after injection caused a significant reduction (p <05. 0) in feed consumption .Famotidine had no significant effect on feed intake in starvation mode. Conclusion: According to these results, it seems that the histamine receptor H2, feed and water consumption of poultry (broiler) does not work.


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