TY - JOUR ID - 35651 TI - Bioorganic investigation of encapsulated Cysteine derivative into polymeric nanocarrier JO - International Journal of Advanced Biological and Biomedical Research JA - IJABBR LA - en SN - 2383-2762 AU - Ali, Ehab M. AU - Hamed, Ahmed AD - Department of Chemistry, University of Fallujah, Iraq Y1 - 2019 PY - 2019 VL - 7 IS - 4 SP - 342 EP - 352 KW - biocompatibility KW - Neuroprotective KW - Polymer KW - biopolymer DO - 10.33945/SAMI/IJABBR.2019.4.6 N2 - In this work, the copolymer-based synthesized Cysteine-loaded nanocarriers prepared by a routine protocol, coprecipitation method. It is the first report to investigate the neuroprotective potential and biocompatibility of Cysteine derivatives loaded into poly(ethylene glycol)-block-poly(ε−caprolactone) methyl ether (PEG-b-PCL). The average size of the polymeric/empty NCs was 89 nm and for polymeric/Synthesized derivative of Cysteine was 126 nm. The Drug Loading efficiency was 81%. The concentration of Polymeric NCs was 2.1 x 10 10 particles/ml and the zeta potential of polymeric/empty and polymeric/ Synthesized derivative of Cysteine NCs -5 mV and -11 mV respectively. Biological part of this work were investigated in the SH-SY5Y human neuroblastoma cell line using cell viability and toxicity assays. The concentration of polymeric NCs below 1 x 10 10 particles/ml described as a zero-point damageable for the cell line. Also the Synthesized derivative of Cysteine encapsulated into polymeric NCs have more neuroprotective effect compared to free Cysteine at lower concentration, and therefore, have a significant neuroprotective potential against Z-VAD-fmk and St-evoked SH-SY5Y cell damage. UR - https://www.ijabbr.com/article_35651.html L1 - https://www.ijabbr.com/article_35651_6d62164d8e142e6198239737cf8d27c9.pdf ER -