Document Type : Case Report


1 Ph.D. Student of Histology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

2 Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

3 Urologist, FEBU at Sapir Hospital, Tehran, Iran



Cancer can significantly have ruining effects on very high of human beings, social, and economic condition. Bladder cancer has been reported as one of the most common cancers and the incidence rates of this cancer is increasing across the world. Cystectomy is a surgery to remove the urinary bladder. In the present study a part of the ileum is used instead of bladder. This study deals with mucosa morphological changes induced in a patient with history of cystectomy surgery, an 8-year follow-up. The specimens were stained with hematoxylin-eosin in order to examine the changes in the thickness of the mucosa processed for light and electronic microscopy. During examining microscopic slides simple epithelial tissue with goblet cells were observed. Also, Lieberkuhn gland and loose connective tissue were seen. The existence of thick layers at cylindrical cells, it could be due to urinating. Finally, goblet cells maybe loss the property of mucosa secretion.


Main Subjects

Aragona, F., De Caro, R., Parenti, A., Artibani, W., Bassi, P., Munari, P.F., Pagano, F., 1998. Structural and ultrastructural changes in ileal neobladder mucosa: a 7-year follow-up. Br. J. Urol., 81(1), 55-61.
Asgari, M.A., Safarinejad, M.R., Shakhssalim, N., Soleimani, M., Shahabi, A., Amini, E., 2013. Quality of life after radical cystectomy for bladder cancer in men with an ileal conduit or continent urinary diversion: A comparative study. Urol. Ann., 5(3), 190-196, doi: 10.4103/0974-7796.115747
Benson, M.C., Seaman, E.K., Olsson, C.A., 1996. The ileal neobladder is associated with a high success and low complication rate. J. Urol., 155, 1585-1588.
Gore, J.L., Litwin, M.S., 2009. The urologic diseases in America project. Quality of care in bladder cancer: Trends in urinary diversion following radical cystectomy. World J. Urol., 27, 45-50.
Gore, J.L., Saigal, C.S., Hanley, J.M., Schonlau, M., Litwin, M.S., 2006. Urologic diseases in America project. Variations in reconstruction after radical cystectomy. Canc., 107, 729-37.
Sherwani Afak, Y., Wazir, B.S., Arif Hamid, Wani, M.S., Rafia Aziz, 2009. Comparative study of various forms of urinary diversion after radical cystectomy in muscle invasive carcinoma urinary bladder. Int. J. Health Sci. (Qassim), 3(1), 3-11.
Stenzl, A., Cowan, N.C., De Santis, M., Jakse, G., Kuczyk, M.A., Merseburger, A.S., Ribal, M.J., Sherif, A., Witjes, J.A., 2009. The updated EAU guidelines on muscle-invasive and metastatic bladder cancer. Eur. Urol., 55(4), 815-825.