Document Type : Original Article


1 Zabol Medicinal Plant Research Center, Zabol University of Medical Sciences, Zabol, Iran

2 Zabol University of Medical Sciences, Zabol, Iran

3 Zabol University of Medical Sciences, Zabol,Iran


Infectious diseases are responsible for thousands of worldwide early death .Many commercial antibiotics have been used to control human's infectious diseases all over the world. Calotropis procera Linn a wild growing plant of Asclepiadaecae family is known to possess multifarious medicinal properties. Total 80 non repetitive clinical E. coli strains recovered during 7 month, and were screened for ESBL production by disc diffusion test, and the MIC and MBC of Calotropis procera chlorophyll extract against ESBL positive E. coli isolates were determined. The results showed a total of 30 of 80 (37.5%) isolates harboured ESBL enzymes. Calotropis procera Calotropis procera extract were effective against ESBL producing E. coli isolates. There is need for a correct and reliable phenotypic test to identify ESBL beta lactamases and also these bioactive plants may help alleviate the problem of drug resistance. The presence of these chemical constituents in this plant is an indication that the plant, if properly screened using additional solvents, could yield drugs with pharmaceutical significance


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