Document Type : Review Article


Faculty of Plant Production, Gorgan University of Agriculture and Natural Resources, Gorgan, Iran



Introduction: Iran is a privileged country with a high rank in plant biodiversity, including 11 of the 13 globally known climates. According to botanists and researchers, there are about 8000 medicinal plants species, which is at least twice the European continent's species diversity.
Methods: Studies have shown that over 2300 plant species in the country have medicinal and aromatic properties and could be as spices andcosmetics. The high diversity of medicinal plants in Iran has made traders aim to export these products. The tariff code (HS Code) for medicinal plants in world customs is 121190. Iran was evaluated as the number one leading country in terms of medicinal plants export in 1998 and the fifth in 2003, and it came to 32 in rankings due to some problems. In 2018, the share of Iran from medicinal plants trade was 440 million dollars, while the total global transaction of medicinal plant import was about 124 billion dollars. This outstanding amount of trade creates unique opportunities for the traders of these products.
Conclusion: The highest export of Iran currently belongs to saffron; damask rose, licorice cumin, and cilantro, with 80-90% of the exports was in bulk and only 10% as essential oils and extracts. The first destinations for medicinal plants export are Pakistan and UAE, followed by Germany, Japan, and China.


Main Subjects

  1. Sefidkon F. (2021). National approach to make a transformation in the economic value of medicinal plants. Iranian Nature Journal, 6(1): 135-143. (in Persian)
  2. Parsa M. (2016). Investigation of economic value of medicinal and industrial plants of rangelands, The first scientific congress of development and promotion of agricultural sciences, natural resources and environment of Iran, Tehran. (in Persian)
  3. Zoleh M. (2011). The role of medicinal plants in economic development of Iran. National Conference on New Achievements in Agriculture, Tehran, (in Persian)
  4. Salehi Sardoei (2021). Domestication of medicinal plants. (1st ed).Nowruzi Press. 225 p. (in Persian)
  5. Salehi Sardoei A, Khalili H. (2020a). Phytochemistry of Medicinal Plants: General (Vol. I). (1st ed).Nowruzi Press. 306 p. (in Persian)
  6. Salehi Sardoei A, Khalili H. (2020c). Phytochemistry of medicinal plants: Non-essential plants (Volume III). (1st ed).Nowruzi Press. 209 p. (in Persian)
  7. Salehi Sardoei A, Shahdadneghad M, Arsalani A, Sadeghi T. (2014). The Effect of Solopotasse Fertilizer on yield and Essential Oil of Cumin (Cuminum cyminum). International journal of Advanced Biological and Biomedical Research, 2(9): 2529-2533.
  8. Salehi Sardoei A, Khalili H. (2020b). Phytochemistry of medicinal plants: Essential plants (Volume II). (1st ed).Nowruzi Press. 209 p. (in Persian)
  9. Salehi Sardoei A, Khalili H. (2020d). Advances in Drought Stress Strategies: Medicinal Plants. (1st ed). Nowruzi Press 350 p. (in Persian)
  10. Koochak H, Seyyednejad SM. (2010). Motamedi, H. Preliminary study on the antibacterial activity of some medicinal plants of Khuzestan (Iran). Asian Pac. J. Trop. Med, 3: 180–184.
  11. Salehi Sardoei A, Shahdadi F, Shahdadneghad M, Sadeghi T. (2014). Effects of Inoculation of ArbuscularMycorrhiza and Growth Regulators on Reducing Sugar contents of Three Medicinal Plants. International Journal for Pharmaceutical Research Scholars, 3(2): 396-402.
  12. Abedini A, Roumy V, Mahieux S, Gohari A, Farimani MM, Rivie C, Samaillie J, Sahpaz S, Bailleul F, Neut C. (2014). Antimicrobial activity of selected Iranian medicinal plants against a broad spectrum of pathogenic and drug multiresistant micro-organisms. Appl. Microbiol, 59: 412–421. doi: 10.1111/lam.12294.
  13. Chitsazian-Yazdi M, Agnolet S, Lorenz S, Schneider B, Es’haghi Z, Kasaian J, Khameneh B, Iranshahi M. (2015). Foetithiophenes C-F thiophene derivatives from the roots of Ferula foetida. Biol, 53: 710–714. doi: 10.3109/13880209.2014.939765. 
  14. Salehi Sardoei A, Shahadadi F, Vakili, MA, Gholamshahi S. (2014). Effects of different gibberellic acid (GA3) on phenolic com pounds and antiradical activity of Marigold (Calendula officinalis). International Journal of Biosciences, 4(3): 80-85.
  15. Baharvand-Ahmadi B, Bahmani M, Naghdi N, Saki K, Baharvand-Ahmadi S, Rafieian-Kopaei M. (2015). Medicinal plants used to treat infectious and non-infectious diseases of skin and skin appendages in city of Urmia, northwest Iran. Pharm. Lett, 7: 189–196. (in Persian)
  16. Pirbalouti AG Malekpoor F, Enteshari S, Yousefi M, Momtaz H, Hamedi B. (2010). Antibacterial Activity of Some Folklore Medicinal Plants Used by Bakhtiari Tribal in Southwest Iran. J. Biol, 2: 2. (in Persian)
  17. Shahidi, B. (2004). Evaluation of antibacterial properties of some medicinal plants used in Iran. Ethnopharmacol, 94: 301–305. doi: 10.1016/j.jep.2004.06.007.
  18. Salehi Sardoei A, Rohany Yazdi M, Shahdadneghad M. (2014). Effect of cycocel on Reducing Sugar, Malondialdehyde and Other Aldehydes in Cannabis Sativa in Flowering Stage. International Journal of Biosciences, 4(6): 127-133.
  19. Lotfipour F, Nazemiyeh H, Fathi-Azad F, Garaei N, Arami S, Talat S, Sadegpour F, Hasanpour R. (2008). Evaluation of Antibacterial Activities of Some Medicinal Plants from North-West Iran. J. Basic Med. Sci, 11: 80–85. Doi: 10.22038/IJBMS.2008.5200
  20. Nariman F, Eftekhar F, Habibi Z, Falsafi T. (2004). Anti-Helicobacter pylori Activities of Six Iranian Plants. Helicobacter, 9: 146–151.
  21. Razavi SM, Zarrini G, Molavi G, Ghasemi G. (2011). Bioactivity of Malva Sylvestris, a Medicinal Plant from Iran. Iran. J. Basic Med., Sci, 14: 574–579.
  22. Rahbarian P, Salehi Sardoei A, Gholamshahi S, Khorshidi JorJandi G. (2014). Relative water content, cell membrane stability, essential oil and morphology of Dracocphalum moldavica are influenced by drought stress and manure. International Journal of Biosciences, 5(1): 421-428.
  23. Imani Z, Asgarpanah J, Hashemi F, Hashemi Hezaveh J. (2015). Composition and antifungal activity of Zhumeria majdae essential oil. Med. Mycol, 1: 13–19. doi: 10.18869/acadpub.cmm.1.4.13
  24. Sepahi S, Ghorani-Azam A, Sepahi S, Asoodeh A, Rostami S. (2014). In Vitro Study to Evaluate Antibacterial and Non-haemolytic Activities of Four Iranian Medicinal Plants. West Indian Med, J., 63: 289–293. doi: 10.7727/wimj.2013.095.
  25. Afshar FH, Delazar A, Asnaashari S, Vaez H, Zolali E Asgharian P. (2018). Screening of Anti-Malarial Activity of Different Extracts Obtained from Three Species of Scrophularia Growing in Iran. J. Pharm. Res, 17: 668–676. doi: 10.4103/1735-5362.258495.
  26. Pirbalouti AG, Bahmani M, Avijgan M. (2009). Anti-Candida Activity of Some of the Iranian Medicinal Plants. J. Biol, 5: 85–88.
  27. Alinezhad H, Baharfar R, Zare M, Azimi R, Nabavi SF, Nabavi SM. (2012). Biological activities of ethyl acetate extract of different parts of Hyssopus angustifolius. Biol, 50: 1062–1066. doi: 10.3109/13880209.2012.655859.
  28. Dehghan H, Sarrafi Y, Salehi P. (2016). Antioxidant and antidiabetic activities of 11 herbal plants from Hyrcania region, Iran. Food Drug Anal, 24: 179–188.
  29. Rahbarian P, Salehi Sardoei. A. (2014). Effects of drought stress and manure on dry herb yield and essential oil content of Dragonhead (Dracocphalum moldavica) in Jiroft erea. International Journal of Bioscience, 4(9): 212-217. doi:
  30. Haddad FMH, Mahbodfar HR, Zamani Z, Ramazani A. (2017). Antimalarial evaluation of selected medicinal plant extracts used in Iranian traditional medicine. J. Basic Med. Sci, 20: 415–422. doi: 10.22038/IJBMS.2017.8583
  31. Ebrahimabadi AH, Ebrahimabadi EH, Djafari-Bidgoli Z, Kashi FJ, Mazoochi A, Batooli H. (2010). Composition and antioxidant and antimicrobial activity of the essential oil and extracts of Stachys inflata Benth from Iran. Food Chem, 119: 452–458.
  32. Shahdadi F, Payandeh M. Salehi Sardoei A. (2021). Comparison of Antioxidant Activity of Dracocephalum polychaetum Bornm and Nepeta cataria and Their Effect on Probiotic Bacteria in a Simulated Gastrointestinal Environment. Journal of Medical Microbiology and Infectious Diseases, 9(1): 5-11. Doi: 10.52547/JoMMID.9.1.5
  33. Dehshiri MM, Aghamollaei H, Zarini M, Nabavi SM, Mirzaei M, Loizzo M.R, Nabavi SF. (2013). Antioxidant activity of different parts of Tetrataenium lasiopetalum. Biol, 51: 1081–1085.
  34. Fathiazad F, Mazandarani M, Hamedeyazdan S. (2011). Phytochemical analysis and antioxidant activity of Hyssopus officinalis from Iran. Adv. Pharm. Bull, 1: 63–67. doi: 10.5681/apb.2011.009.
  35. Pourmorad F, Hosseinimehr SJ Shahabimajd N. (2006). Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants. J. Biotechnol, 5: 1142–1145.
  36. Dehghan H, Sarrafi Y, Salehi P, Ebrahimi SN. (2017). α-Glucosidase inhibitory and antioxidant activity of furanocoumarins from Heracleum persicum. Chem. Res, 26: 849–855.
  37. Khazaeli P, Goldoozian R, Sharififar F. (2009). An evaluation of extracts of five traditional medicinal plants from Iran on the inhibition of mushroom tyrosinase activity and scavenging of free radicals. J. Cosmet. Sci, 31: 375–381. doi: 10.1111/j.1468-2494.2009.00503.x.
  38. Hamzeloo-Moghadam M, Khalaj A, Malekmohammadi M. (2015). Cytotoxic Activity and Apoptosis Induction of Hypericum scabrum L. Iran. Red Crescent Med. J, 17: e19453. doi: 10.5812/ircmj.19453.
  39. Rahbarian P, Salehi Sardoei A. (2014). Effects of Drought Stress and Manure on Plant Growth Promoting Stability in Dragonhead (Dracocephalum moldavica). International Journal of Plant, Animal and Environmental Sciences, 4(3): 324-329. DOI: 12692/ijb/4.9.212-217
  40. Sonboli A, Mojarrad M, Ebrahimi SN, Enayat S. (2010). Free Radical Scavenging Activity and Total Phenolic Content of Methanolic Extracts from Male Inflorescence of Salix aegyptiaca Grown in Iran. J. Pharm. Res, 9: 293–296.
  41. Salehi Sardoei A, Rohany Yazdi M, Arbabi M, Jahantigh M. (2014). The Cycocel effect on the Delta-9-tetrahydrocannabinol, protein, soluble carbohydrates on the Cannabis types (Cannabis Sativa) at the flowering stage. International Journal of Biosciences, 4(1): 125-130. DOI: 12692/ijb/4.1.125-130
  42. Jassbi AR, Firuzi O, Miri R, Salhei S, Zare S, Zare M, Masroorbabanari M, Chandran JN, Schneider B, Baldwin IT. (2016). Cytotoxic activity and chemical constituents of Anthemis mirheydari. Biol, 54: 2044–2049. doi: 10.3109/13880209.2016.1141220.
  43. Esmaeilbeig M, Kouhpayeh SA, Amirghofran Z. (2015). An Investigation of the Growth Inhibitory Capacity of Several Medicinal Plants from Iran on Tumor Cell Lines. J. Cancer Prev, 8: e4032. doi: 10.17795/ijcp-4032.
  44. Asadi-Samani M, Rafieian-Kopaei M, Lorigooini Z, Shirzad HA. (2018). screening of growth inhibitory activity of Iranian medicinal plants on prostate cancer cell lines. BioMedicine, 8: 16–21. doi: 10.1051/bmdcn/2018080208.
  45. Sahranavard S, Naghibi F, Mosaddegh M, Esmaeili S, Sarkhail P, Taghvaei M, Ghafari S. (2010). Cytotoxic activities of selected medicinal plants from Iran and phytochemical evaluation of the most potent extract. Pharm. Sci, 4: 133–137.
  46. Salehi Sardoei A, Shahdadneghad M. (2014). Effects of Foliar Application of Gibberellic Acid on Chlorophyll and Carotenoids of Marigold (Calendula officinalis). International journal of Advanced Biological and Biomedical Research, 2(6): 1887-1893.
  47. Hasanein P, Felehgari Z, Emamjomeh A. (2016). Preventive effects of Salvia officinalis against learning and memory deficit induced by diabetes in rats: Possible hypoglycaemic and antioxidant mechanisms. Neurosci. Lett, 622; 72–77. doi: 10.1016/j.neulet.2016.04.045.
  48. Ebrahimzadeh MA, Pourmorad F, Bekhradnia AR. (2008). Iron chelating activity, phenol and flavonoid content of some medicinal plants from Iran. J. Biotechnol, 7: 3188–3192.
  49. Adhami HR, Farsam H, Krenn L. (2011). Screening of Medicinal Plants from Iranian Traditional Medicine for Acetylcholinesterase Inhibition. Res, 25: 1148–1152. doi: 10.1002/ptr.3409.
  50. Behzadi M, Emamipour Y, Koduri MR, Salehi Sardoei A. (2014). Determining the suitable planting date of Roselle (Hibiscus sabdariffa) in Kerman’s green- belt and landscape. Journal of Mddle east Applied Science and Technology, 23(2): 130-134.
  51. Abbas-Mohammadi M, Farimani MM, Salehi P Ebrahimi SN Sonboli A, Kelso C, Skropeta D. (2018). Acetylcholinesterase-inhibitory activity of Iranian plants: Combined HPLC/bioassay-guided fractionation, molecular networking and docking strategies for the dereplication of active compounds. Pharm. Biomed. Anal, 158: 471–479. doi: 10.1016/j.jpba.2018.06.026.
  52. Lorigooini Z, Kobarfard F, Ayatollahi A. (2014). Anti-platelet aggregation assay and chemical composition of essential oil from Allium atroviolaceum Boiss growing in Iran. J. Biosci, 5: 151–156.
  53. Behzadi M, Emamipour Y, Koduri MR, Salehi Sardoei A. (2014). The effect of planting time on performance of Roselle (Hibiscus sabdariffa) to use in urban green space. Journal of Mddle east Applied Science and Technology, 24(2): 156-159.
  54. Jazayeri SB, Amanlou A, Ghanadian N, Pasalar P, Amanlou M. (2014). A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine. DARU J. Pharm. Sci, 22: 17. doi: 1186/2008-2231-22-17
  55. Asgary S, Nader IGH, Sarrafzadegan N, Mohammadifard N, Mostafavi S, Vakili R. (2000). Antihypertensive and Antihyperlipidemic Effects of Achillea Wilhelmsii. Drugs Exp. Clin. Res, 26: 89–93.
  56. Karimi G, Hosseinzadeh H, Ettehad N. (2004). Evaluation of the Gastric Antiulcerogenic Effects of Portulaca oleracea Extracts in Mice. Phytother. Res, 18: 484–487. doi: 10.1002/ptr.1463.
  57. Khonche A, Huseini HF, Abdi H, Mohtashami R, Nabati F, Kianbakht S. (2017). Efficacy of Mentha pulegium extract in the treatment of functional dyspepsia: A randomized double-blind placebo-controlled clinical trial. Ethnopharmacol, 206: 267–273. doi: 10.1016/j.jep.2017.05.026.
  58. Niazmand S, Khooshnood E, Derakhshan M. (2010). Effects of Achillea wilhelmsii on rat’s gastric acid output at basal, vagotomized, and vagal-stimulated conditions. Mag, 6: 282–285. doi: 10.4103/0973-1296.71791.