Evaluation of anti-bacterial (Escherichia coli and Staphylococcus aureus) and anticancer effects of silver nanoparticles synthesized by Melissa officinalis L. extract on several cancer cells (A549, MCF-7, and HeLa)

Bashiri Godarzi, Faezeh; Shamaei, Shabnam

doi:10.22034/ijabbr.2022.548282.1380

Document Type : Original Article

Authors

Department of Chemistry, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran

https://doi.org/10.22034/ijabbr.2022.548282.1380

Abstract

ABSTRACT. Silver nanoparticles (AgNPs) with antimicrobial and anticancer properties have been widely used in a variety of fields. This research investigated the antimicrobial effects and toxicity of AgNPs synthesized using the extract of the medicinal plant lemon balm, Melissa officinalis L., on 3 cancer cell lines (A549, MCF-7, and HeLa). AgNPs were biologically synthesized using the extract of M. officinalis. After physical and chemical evaluation, the anti-bacterial properties of the synthesized nanoparticles were evaluated in Escherichia coli and Staphylococcus aureus. Finally, the inhibitory effect of synthesized nanoparticles was assessed by the MTT assay on 3 cancer cell lines. With an average size of 17 nm, the nanoparticles synthesized by M. officinalis L. extract had a significant inhibitory and lethal effect on 2 bacteria. The findings indicated that the synthesized nanoparticles had more inhibitory and bactericidal effects on S. aureus as a gram-positive bacterial strain. The MBC of nanoparticles synthesized by M. officinalis extract was 500 μg/mL for S. aureus and 700 μg/mL for E. col. At a concentration of 50 g/mL, the synthesized AgNPs showed more than 50% inhibitory effect on different cell lines. Our results demonstrate that medicinal plants can be used in the successful synthesis of biological AgNPs. The synthesized AgNPs can be utilized as effective medicinal agents in the management of several cancers due to their coating made of effective secondary metabolites and the release of silver ions (Ag+).

Graphical Abstract

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References

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International Journal of Advanced Biological and Biomedical Research

Evaluation of anti-bacterial (Escherichia coli and Staphylococcus aureus) and anticancer effects of silver nanoparticles synthesized by Melissa officinalis L. extract on several cancer cells (A549, MCF-7, and HeLa)

References

References

Volume 10, Issue 1
January 2022
Pages 57-71

Evaluation of anti-bacterial (Escherichia coli and Staphylococcus aureus) and anticancer effects of silver nanoparticles synthesized by Melissa officinalis L. extract on several cancer cells (A549, MCF-7, and HeLa)

References

References

Volume 10, Issue 1January 2022Pages 57-71

Volume 10, Issue 1
January 2022
Pages 57-71