Document Type : Original Article
Authors
1 Postgraduate Student, experimental sciences, Tabriz, Iran
2 Breast Surgery Fellowship, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Introduction: Important genes that may be expressed in women candidates for mastectomy due to breast cancer are important. The expression of these genes in these women can play an important role in the treatment of these patients. The aim of this study was to investigate the expression level of glutathione peroxidase and glutathione reductase genes in mastectomies women.
Procedure: After cell culture, the cell suspension was planted in 96-well microplates and treated for 24 hours in a CO2 incubator at 37 °C. To synthesize cDNA, extracted RNA molecules were used with the help of Fermentaz Revert Aid TM kit, produced in the United States.
Results: The concentration of 500 micrograms of nanoparticles caused the death of more than 60% of MCF 7 cells (P< 0.001) while there was no significant difference in all concentrations of nanoparticles on the normal HEK293 cell line.
Conclusion: The anti-tumor effects of zinc oxide nanoparticles were shown in increasing the expression of glutathione peroxidase and glutathione reductase genes in MCF-7 breast cancer cell line of mastectomy candidates.
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- Abdollahi M H, Foruzan-Nia K, Behjati M, Bagheri B, Khanbabayi-Gol M, Dareshiri S, Pishgahi A, Zarezadeh R, Lotfi-Naghsh N, Lotfi-Naghsh A, Naghavi-Behzad M. (2014). The effect of preoperative intravenous paracetamol administration on postoperative fever in pediatrics cardiac surgery. Nigerian medical journal: journal of the Nigeria Medical Association, 55(5): 379-383. [Crossref], [Google Scholar], [Publisher]
2. Gol MK, Jabarzade F, Zamanzadeh V. (2017). Cultural competence among senior nursing students of medical universities in North-West Iran. Nurs Midwifery J., 15(8): 612-9. [Google Scholar]
- Haghdoost M, Mousavi S, Gol MK, Montazer M. (2019). Frequency of Chlamydia trachomatis infection in spontaneous abortion of infertile women during first pregnancy referred to tabriz university of medical sciences by nested PCR method in 2015. International Journal of Women's Health and Reproduction Sciences, 7 (4): 526-530. [Crossref], [Google Scholar], [Publisher]
4. Eghdam-Zamiri R, Gol MK. (2020). Effects of ginger capsule on treatment of nausea and vomiting in patients receiving cisplatin undergoing mastectomy: a randomized clinical trial. The Iranian Journal of Obstetrics, Gynecology and Infertility, 22 (11): 15-21. [Crossref], [Google Scholar], [Publisher]
5. Mobaraki-Asl N, Ghavami Z, Gol MK. (2019). Development and validation of a cultural competence questionnaire for health promotion of Iranian midwives. Journal of Education and Health Promotion, 8: 179. [crossref], [Google Scholar], [Publisher]
6. Gol MK, Dorosti A, Montazer M. (2019). Design and psychometrics cultural competence questionnaire for health promotion of Iranian nurses. Journal of education and health promotion, 8. [Crossref], [Google Scholar], [Publisher]
7. Shahidi N, Mahdavi F, Gol MK. (2020). Comparison of emotional intelligence, body image, and quality of life between rhinoplasty candidates and control group. Journal of Education and Health Promotion, 9: 153. [crossref], [Google Scholar], [Publisher]
8. Shirvani M, Soufi F, Nouralishahi A, Vakili K, Salimi A, Lucke-Wold B, Mousavi F, Mohammadzadehsaliani S, Khanzadeh S. (2022). The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis. BioMed Research International. [crossref], [Google Scholar], [Publisher]
- Shirvani M, Soufi F, Nouralishahi A, Vakili K, Salimi A, Lucke-Wold B, Mousavi F, Mohammadzadehsaliani S, Khanzadeh S. (2022). The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis. BioMed Research International. [crossref], [Google Scholar], [Publisher]
10. Mahmoudi H, Nouralishahi A, Mohammadzadehsaliani S. (2022). Stem cell-derived nano-scale vesicles promotes the proliferation of retinal ganglion cells (RGCs) by activation PI3K/Akt and ERK pathway. Nanomedicine Research Journal, 7(3): 288-293. [Crossref], [Google Scholar], [Publisher]
11. Kheradjoo H, Nouralishahi A, Hoseinzade Firozabdi M S, Mohammadzadehsaliani S. (2022). Mesenchymal stem/stromal (MSCs)-derived exosome inhibits retinoblastoma Y-79 cell line proliferation and induces their apoptosis. Nanomedicine Research Journal, 7(3): 264-269. [Crossref], [Google Scholar], [Publisher]
12. Mohammadzadehsaliani S, Dehnavi N K, Nouralishahi A, Kheradjoo H. (2023). Photorefractive keratectomy in Hyperopia: Refractive outcomes and Patients’ satisfaction. Academic Journal, 33: 10-1. [Google Scholar], [Publisher]
13. Parisa N., Kamaluddin M. T., Saleh M. I., Sinaga E. S., Umi Partan R., Irfannuddin I. (2023). 'Flavonoids as Antioxidants: A Review on Tempuyung Plant (Sonchus Arvensis)', Journal of Medicinal and Chemical Sciences, 6(10):2310-2318. doi: [crossref], [Publisher]
14. Jabbari H. (2022). Synthesis and Evaluation of New Derivatives of Busulfan as an Anticarcinogenic Drug against k562 Cancer Cells Using the AO / PI Method, The Open Medicinal Chemistry Journal, 15. [Crossref], [Google Scholar], [Publisher]
15. Forutan Mirhosseini A, Jabbari H, Nouralishahi A, Bahman Z, Yahyazadeh Jasour S, Nekouei A. (2022). Ag-ZnO nanoparticles: synthesis, characterization, antibacterial activity on S. mutans, along with cytotoxic effect on U87 cell line. Nanomedicine Research Journal, 7(3): 254-263. [Crossref], [Google Scholar], [Publisher]
16. Saliminasab M, Jabbari H, Farahmand H, Asadi M, Soleimani M, Fathi A. (2022). Study of antibacterial performance of synthesized silver nanoparticles on Streptococcus mutans bacteria. Nanomedicine Research Journal, 7(4): 391-396. [Crossref], [Google Scholar], [Publisher]
- Aghababai beni A, Jabbari H. (2022). nanomaterials for enviromental applications. results in engineering, 15. [Crossref], [Google Scholar], [Publisher]
18. Abbasi S, İlhan A, Jabbari H, Javidzade P, Safari M, Abolhasani Zadeh F. (2022). Cytotoxicity evaluation of synthesized silver nanoparticles by a Green method against ovarian cancer cell lines. Nanomedicine Research Journal, 7(2): 156-164. [Crossref], [Google Scholar], [Publisher]
19. Liu J, Kadhim MM, Ansari MJ, Ebadi AG. (2022). Design organic material with acceptor-π-donor configuration for high performance solar cells. Computational and Theoretical Chemistry, 1212, 113729. [Crossref], [Google Scholar], [Publisher]
20. Jabbari H. (2020). Selective Anomeric Deacetylation of Per-Acetylated Carbohydrates Using (i-Pr) 3Sn (OEt) and Synthesis of New Derivatives. Journal of Molecular Biology Research, 10(1): 166-166. [Crossref], [Google Scholar], [Publisher]
- Jabbari H, Shendabadizad R. (2020). GC-MS analysis of essential oils of Humulusn lupulus, Malva Sylvestris and thymus plants in water solvent. Journal of Advanced Pharmacy Education & Research, 10. [Crossref], [Google Scholar], [Publisher]
22. Jabbari H. (2020). Synthesis of carbohydrate esters and investigation reaction of Phosphoryl chloride from anomeric position of per-acetylated carbohydrates. Arch. Pharm. Pract, 1, 71-75. [Google Scholar], [Publisher]
23. Ghian H, Noroozi N, Jabbari H. (2018). Using of ozonation method for filtertion of mineral water. Communications In Catalysis, 1(1): 20-31. [Crossref], [Google Scholar], [Publisher]
- Jabbari H, Pesyan NN. (2017). Synthesis of polyol esters by p-toluenesulfonic acid catalyst as synthetic lubricant oils. Asian Journal of Green Chemistry, 1: 41-45. [Google Scholar]
25. Jabbari H, Noroozi Pesyan N. (2017). Production of biodiesel from jatropha curcas oil using solid heterogeneous acid catalyst. Asian J. Green Chem, 1, 16-23. [Google Scholar]
26. Jabbari H. (2018). Synthesis of Neopenthylglycolesters using homogeneous and heterogeneous catalysts as synthetic lubricant base oils. Communications In Catalysis, 1(1): 11-19. [Crossref], [Google Scholar], [Publisher]
27. Mohammadi-Aghdam S, Jabbari H, Pouralimardan O, Divsar F, Amini I, Sajjadifar S. (2019). One-pot synthesis of highly regioselective β-azido alcohols catalyzed by Brønsted acidic ionic liquids. Quarterly Journal of Iranian Chemical Communication, 7 (22): 15-28. [Crossref], [Google Scholar], [Publisher]
28. Jabbari H, Khalafy J, Najafi Moghadam P. (2019). Synthesis of neopentyl glycol and ethylene glycol esters by fatty acids in the presence of acidic ion exchange resin catalyst. Iranian chemical communication, 3(8): 244-253. [Google Scholar], [Publisher]
- Khosravaniardakani S. (2022). Vaping Products And Asthma In Youths: A Review Of The Prospective Study. International Journal of Medical Investigation, 11(1). [Google Scholar], [Publisher]
30. Khosravaniardakani S, Bokov DO, Mahmudiono T, Hashemi SS, Nikrad N, Rabieemotmaen S, Abbasalizad-Farhangi M. (2022). Obesity Accelerates Leukocyte Telomere Length Shortening in Apparently Healthy Adults: A Meta-Analysis. Frontiers in Nutrition, 9, 139. [Crossref], [Google Scholar], [Publisher]
31. Ahadiat SA, Shirazinia M, Shirazinia S, Garousi S, Mottahedi M, Jalali AB, Dahooiyeh AB, Pourmohammadi-Shahrbabaki E, Baghsheikhi H, Afzalian A, Varshochi S. (2022). Role of Telemedicine in Management of Patients During the COVID-19 Pandemic. Kindle, 2(1): 1-191. [Google Scholar], [Publisher]
32. Khosravaniardakani S. (2022). The Effect of Cigarette and Its Nicotine Content on The Heart Health. International Journal of New Chemistry, 9(Spring Special), 102-107. [Google Scholar], [Publisher]
33. Khosravaniardakani S, Anbardar MH, Khodamoradi S, Peyravi S. (2022). Epidemiological and Pathological Characteristics of Renal Cell Carcinoma with Outcome Evaluation: A Single Center Study from Shiraz, Iran. International Journal of Medical Investigation, 11(2). [Google Scholar], [Publisher]
34. Mahkooyeh SA, Eskandari S, Delavar E, Milanifard M, Mehni FE. (2022). Chemical laboratory findings in children with covid-19: A systematic review and meta-analysis. Eurasian Chemical Communications, 338-346. [crossref], [Google Scholar], [Publisher]
35. Mirakhori F, Moafi M, Milanifard M, Tahernia H. (2022). Diagnosis and Treatment Methods in Alzheimer's Patients Based on Modern Techniques: The Orginal Article. Journal of Pharmaceutical Negative Results, 1889-1907. [Crossref], [Google Scholar], [Publisher]
- Birmangi S. (2022). A Review of the Effect of Corona on the Human Brain – Short Review, Eurasian Journal of Chemical, Medicinal and Petroleum Research, 1(3): 80-87.
37. Margy S. (2022). A Review of the Effect of Brain imaging-Short Review. Eurasian Journal of Chemical, Medicinal and Petroleum Research, 1(3): 88-99. [Google Scholar]
38. Birman D. (2023). Investigation of the Effects of Covid-19 on Different Organs of the Body. Eurasian Journal of Chemical, Medicinal and Petroleum Research, 2(1): 24-36. [crossref], [Google Scholar], [Publisher]
39. Esmaeilzadeh AA, Yaseen MM, Khudaynazarov U, Al-Gazally ME, Opulencia MJ, Jalil AT. (2022). Recent advances on electrochemical and optical biosensing strategies for monitoring of microRNA-21: A review. Analytical Methods. [Crossref], [Google Scholar], [Publisher]
- Esmaeilzadeh AA, Kashian M, Salman HM, Alsaffar MF, Jaber MM, Soltani S, Amiri Manjili D, Ilhan A, Bahrami A, Kastelic JW. (2022). Identify Biomarkers and Design Effective Multi-Target Drugs in Ovarian Cancer: Hit Network-Target Sets Model Optimizing. Biology, 11(12): 1851. [crossref], [Google Scholar], [Publisher]
- Esmaeilzadeh AA, Rasoolzadegan S, Arabi AR, Soofi D, Rajaei Ramsheh SS, Saad Ahmed W, Moaref Pour R. (2022). Cytotoxic study of green synthesized pure and Ag-doped α-Fe2O3 nanoparticles on breast cancer (MCF-7) cell line. Nanomedicine Research Journal, 7(4): 370-377. [crossref], [Google Scholar], [Publisher]
- Shirazi AO, Jahandideh H, Yarahmadi A, Milanifard M, Delarestaghi MM, Maleki M. (2020). The effect of apple cider vinegar in the treatment of chronic rhinosinusitis. Medical Science, 24(104): 2467-2474.
[Google Scholar], [Publisher]
- Ahmadi SE, Farzanehpour M, Fard AM, Fard MM, Ghaleh HE. (2022). Succinct review on biological and clinical aspects of Coronavirus disease 2019 (COVID-19). Romanian Journal of Military Medicine, 356-365. [Crossref], [Google Scholar], [Publisher]
- Milanifard M, Hassanzadeha G. (2018). Anthropometric study of nasal index in Hausa ethnic population of northwestern Nigeria. J Contemp Med Sci.,4(1): 26-29. [Google Scholar], [Publisher]
- Mileski M, Pannu U, Payne B, Sterling E, McClay R. (2020). The impact of nurse practitioners on hospitalizations and discharges from long-term nursing facilities: a systematic review. Healthcare, 8(2): 114. [Crossref], [Google Scholar], [Publisher]
- Borba MG, Val FF, Sampaio VS, Alexandre MA, Melo GC, Brito M, Mourão MP, Brito-Sousa JD, Baía-da-Silva D, Guerra MV, Hajjar LA. (2020). Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial. JAMA network open,3(4): e208857-e208857. [Google Scholar], [Publisher]
47. Milanifard M. (2021). Effects of Micronutrients in Improving Fatigue, Weakness and Irritability. GMJ Medicine, 5(1): 391-395. [Google Scholar]
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