Document Type : Original Article

Authors

• Olumakinde Charles Omiyale ¹
• Blessing Ifeoluwa Ogunniran ²
• Mercy Ogochukwu Ezeh ³
• Mubaraq Damilare Yussuf ⁴
• Confidence Damian Oparah ⁵
• Fawaz Isshak ⁶

¹ Department of Pharmacology, Toxicology and Therapeutics, College of Medicine, University of Lagos, 101014, Nigeria

² Department of Environmental Science, School of Environment, Northeast Normal University, 130024, China

³ Department of Plant Breeding, Crop Improvement Unit, Cocoa Research Institute of Nigeria (CRIN), Nigeria

⁴ Department of Biochemistry, Faculty of Life Sciences, Lagos State University, Lagos, 102101, Nigeria

⁵ Department of Internal Medicine, National Hospital Abuja, Abuja, 900211, Nigeria

⁶ Department of Horticulture, Faculty of Agriculture and Natural Resources, Kwame Nkrumah University of Science and Technology, Ghana

Abstract

The objective of the current study was to assess the ethanolic and methanolic extracts of Carica papaya's hypoglycemic effects. Yeast glucose uptake, muscle glucose uptake, and glucose adsorption capacity were used to measure the extracts' in vitro hypoglycemic effects. The antioxidant capacity of the extracts was assessed by investigating how they affect lipid peroxidation brought on by iron (II) sulphate and sodium nitroprusside. The findings showed that glucose was absorbed by both the ethanolic and methanolic extracts of Carica papaya, and that this adsorption significantly increased as the concentration of glucose rose. There were no variations in their adsorption capabilities that were statistically significant (p=0.05). The yeast cells were also stimulated to take up glucose by the plant extracts, and this stimulation was influenced by the sample and glucose content. In the study's muscle glucose uptake, the ethanolic extract of Carica papaya leaves showed substantially greater (p=0.05) performance than the methanolic of the same leaves with increasing concentration. The study's findings showed that the plant's methanolic extract was substantially more potent than its ethanolic (p=0.05). In addition, the methanolic extract considerably inhibited the generation of MDA (malondialdehyde) in the liver and brain homogenates more than the ethanolic extract did. Both plant extracts also exhibit dose-dependent inhibition of the various pro-oxidant agents (Iron (II) Sulphate and sodium nitroprusside) caused fatty acid oxidation tissues present in the brain and liver.

Graphical Abstract

Keywords

• Carica papaya
• Hypoglycemic
• Antioxidant activity
• Lipid peroxidation
• Malondialdehyde

Main Subjects

• Biochemistry

 

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