One of the major issues of increasing agricultural production, is adaptation of technology to specific climatic variables in cultivated areas. Knowing the weather and climatic condition and periodic yearly and multi-year changes of meteorological phenomena and deviations from normal values are of major requirements of modern agriculture. In this study, daily, monthly and annual weather data of synoptic stations in East-Azerbaijan province was gathered from Iran Meteorological Organization and then, the homogeneity of data were examined by run test method. To study agro-climatic features of viticulture, deviation from optimal conditions and the degree of active days index (GDD) methods are used. Based on the analysis of deviations from optimal conditions at different altitudes in the study area, Malekan station has optimal conditions for planting, among the stations. This is important in terms of development of cultivation areas and commercial production of crops. Based on the agro-climatic analysis, South and Northeast regions (Malekan and Ahar stations) are most suitable areas of viticulture in the province.