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Study on Subclinical and Clinical Marek's Disease (MD) in the Broiler Chickens Using Histopathology
Document Type : Original Article
Author
Assistant professor of Veterinary Medicine, Razi vaccine and serum research institute, branch of Isfahan research center for agricultural. Vet. Dept., Isfahan, Iran
Abstract
Marek's disease (MD) is the most common lymphoproliferative diseases of chickens; During the last year the incidence of MD was investigated among slaughter houses and suspected broiler farms, located in Isfahan (Iran) as the region of highest density of poultry husbandry by histopathology, For subclinical MD investigation, in total 1550 chickens originated from slaughter houses were examined, Parallely for clinical MD investigation, 100 chickens from 10 broiler farms were examined.Based on the obtained results, about 6.81% of the liver samples (with average age of 60 days) collected from slaughter houses showed pleomorphic lymphoid cell proliferation and infiltration of mononuclear cells as subclinical MD. The microscopic results of examined broilers (average age of 57 days) with clinical signs of MD , showed pleomorphic lymphoid cell proliferation in sciatic nerves (62%) , spleens (66% ) and livers(71%). Now in Iran, the outbreaks of subclinical and clinical MD in broiler chickens increased but MD vaccination is not permitted so regarding to the results it will be to an obligation for hatchery MD vaccination, and/or decreasing the slaughtering age besides a good bio security of broilers farms
Keywords
Bacon LD, Witter R L , Silva R F (2001). Characterization and experimental reproduction of peripheral neuropathy in White Leghorn chickens. Avian Pathology. 30 (5): 487–499.
Calnek BW, Harris RW, Buscaglia C, Schat KA, lucio B(1998). Relationship between the immunosuppressive potential and the pathotype of Marek's disease virus isolates. Avian Diseases. 42:124-132.
Carter GR, Flores EF, Wise DJ (2006). "Herpesviridae", A Concise Review of Veterinary Virology. http://www.ivis.org /advances/ Carter /Part2Chap11 / chapter . Retrieved ,2006-06-10.
Fadly AM , Ewer DL (2008). Enhancement of Avian Retrovirus· induced B~cell Lymphoma by Marek's Disease, In: Saif YM; Fadly AM; Glisson IR; McDougald LR; Nolan LK ; Swayane DE; Diseases of poultry , II ed., edited by. Black wall publication, Iowa State University Press, Iowa, USA, p:558-559.
Marsh JD, Bacon LD, Fadly AM (1995). Effects of serotype 2 and 3 marek’s disease vaccines on the development of avian leucosis virus induced pre-neoplastic bursal follicles. Avian Dis. 39:743-751.
Okazaki W, Witter RL, Romero C, Nazerian K, Sharma M, Fadly AM, Ewert D(1980). Induction of lymphoid leukosis transplantable tumours and the establishment of Iymphoblastoid cell lines. Avian Pathol. 9: 311-329.
Otaki Y, Nunoya T, Tajima T, Kato S, Nomura Y(1988). Depression of vaccinal immunity to Marek’s disease by infection with chicken anaemia agent. Avian Pathol.17:333-347.
Soffer D, Resnick-Roguel N, Eldor A, Kotler M(1990). Multifocal vascular tumors in fowl induced by a newly isolated retrovirus. Cancer Res. 50:4787-93.
Spencer L(1984). Progress towards eradication of lymphoid leukosis viruses, A review, Avian Pathol. 13:599-619.
Spencer JL, Chan M, Nandin Davis S (2000). Relationship between egg size and subgroup J avian leukosis virus in eggs from broiler breeders. Avian Pathol. 29:617-622.
Thomas CJ , Ronald DH, Orval WK (1997). Veterinary Pathology. 6th ed. , pp:1-25.
Witter, R.L.(1997). Increased Virulence of Marek's Disease Virus Field Isolates, Avian Diseases, 41.(1). p.149-163.
Witter RL, Schat KA(2003). "Marek's disease." In: Saif, Y.M., Fadly, A.M.; Glisson, I.R.; McDougald,
L.R.; Nolan, L.K. ; Swayane, D.E. Diseases of Poultry, II ed., edited by Black wall publication, Iowa State University Press. Iowa, USA, p. 407-464.
Calnek BW, Harris RW, Buscaglia C, Schat KA, lucio B(1998). Relationship between the immunosuppressive potential and the pathotype of Marek's disease virus isolates. Avian Diseases. 42:124-132.
Carter GR, Flores EF, Wise DJ (2006). "Herpesviridae", A Concise Review of Veterinary Virology. http://www.ivis.org /advances/ Carter /Part2Chap11 / chapter . Retrieved ,2006-06-10.
Fadly AM , Ewer DL (2008). Enhancement of Avian Retrovirus· induced B~cell Lymphoma by Marek's Disease, In: Saif YM; Fadly AM; Glisson IR; McDougald LR; Nolan LK ; Swayane DE; Diseases of poultry , II ed., edited by. Black wall publication, Iowa State University Press, Iowa, USA, p:558-559.
Marsh JD, Bacon LD, Fadly AM (1995). Effects of serotype 2 and 3 marek’s disease vaccines on the development of avian leucosis virus induced pre-neoplastic bursal follicles. Avian Dis. 39:743-751.
Okazaki W, Witter RL, Romero C, Nazerian K, Sharma M, Fadly AM, Ewert D(1980). Induction of lymphoid leukosis transplantable tumours and the establishment of Iymphoblastoid cell lines. Avian Pathol. 9: 311-329.
Otaki Y, Nunoya T, Tajima T, Kato S, Nomura Y(1988). Depression of vaccinal immunity to Marek’s disease by infection with chicken anaemia agent. Avian Pathol.17:333-347.
Soffer D, Resnick-Roguel N, Eldor A, Kotler M(1990). Multifocal vascular tumors in fowl induced by a newly isolated retrovirus. Cancer Res. 50:4787-93.
Spencer L(1984). Progress towards eradication of lymphoid leukosis viruses, A review, Avian Pathol. 13:599-619.
Spencer JL, Chan M, Nandin Davis S (2000). Relationship between egg size and subgroup J avian leukosis virus in eggs from broiler breeders. Avian Pathol. 29:617-622.
Thomas CJ , Ronald DH, Orval WK (1997). Veterinary Pathology. 6th ed. , pp:1-25.
Witter, R.L.(1997). Increased Virulence of Marek's Disease Virus Field Isolates, Avian Diseases, 41.(1). p.149-163.
Witter RL, Schat KA(2003). "Marek's disease." In: Saif, Y.M., Fadly, A.M.; Glisson, I.R.; McDougald,
L.R.; Nolan, L.K. ; Swayane, D.E. Diseases of Poultry, II ed., edited by Black wall publication, Iowa State University Press. Iowa, USA, p. 407-464.
Witter RL, Shanna M, Fadly AM(1980). Pathogenicity of variant Marek's disease virus isolates invaccinated and unvaccinated chickens, Avian Diseases 24. (1) p.210-232.
Witter RL, Shanna M, Lee F, Opitz HM, Henry CW(1984). Field trials to test the efficacy of polyvalentMarek's disease vaccines in broilers, Avian Diseases 28, (1) p. 44-60.
Witter RL, Shanna M, Lee F, Opitz HM, Henry CW(1984). Field trials to test the efficacy of polyvalentMarek's disease vaccines in broilers, Avian Diseases 28, (1) p. 44-60.
Volume 1, Issue 8 - Serial Number 8
July and August 2013Pages 795-801
- Receive Date 17 August 2014
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