Document Type : Original Article


Department of fisheries, Hamoun International Wetland Research Institute, University of Zabol, Zabol, Iran.



Recently, the effects of antimicrobial activity of silver nanoparticles was considered by researcher because of Bacterial resistance to antimicrobial agents in chemical.The aim of this study was to evaluate the antimicrobial activity of the gold nanoparticles on Escherichia coli. Gold nanoparticles are chemically synthesized. Standard strain of E. coli was cultured in a nutrient broth. Minimum Inhibitory Concentration (MIC) and minimum bactericidal concentration (MBC) was determined by microdilution. The results showed that gold nanoparticles have good inhibitory effect against E.coli have been studied.


Chen, W.Y., Lin, J.Y., Chen, W.J., Luo, L., Wei-GuangDiau, E., Chen, Y.C., 2010. Functional gold nanoclusters as antimicrobial agents for antibiotic-resistant bacteria. Nanomed, (Lond)., 5(5), 755-64.
Grace, A.N., Pandian, K., 2007. Antibacterial efficacy of aminoglycosidic antibiotics protected gold nanoparticles: A brief study. Colloid. Surf. A., 297(1-3), 63-70.
Hernández-Sierra, J.F., Ruiz, F., Cruz Pena, D.C., Martínez-Gutiérrez, F., Martínez, A.E., de Jesús Pozos Guillén, A., 2008. The antimicrobial sensitivity ofStreptococcus mutans to nanoparticles of silver, zinc oxide, and gold.
Nanomed. Nanotechnol., 4, 237-40.
Hernandez-Sierra, J.F., Ruiz, F., Pena, D.C.C., Martinez-Gutierrez, F., Martinez, A.E., Guillen, A.D.J.P., Tapia-Parez, H., Castanon, G.M., 2008. The antimicrobial sensitivity of Streptococcus mutans to nanoparticles of silver, zinc oxide, and gold Nanomedicine: Nanotechnol. Biol. Med., 4(3), 237-240.
Kalish Waralal, K., Dee Pak, V., Ram Kumar Pandian, S., Kottaismary, M., Barathmanikanth, S., Kartikeyan, B., Gurunathan, S., 2010. Biosynthesis of gold & silver nanoparticles using Brevibacteriumcasei. Colloid. Surf.
Biointerf., 77(2), 257-262.
Kaviya, S., Santhanalakshmi, J., Viswanathan, B., Muthumary, J., Srinivasan, K., 2011. Biosynthesis of silver nanoparticles using citrus sinensis peel extract and its antibacterial activity. Spectrochim. Acta. Mol. Biomol. Spectrosc., 79, 594-98.
Mubarak Ali, D., Thajuddin, N., Jeganathan, K., Gunasekaran, M., 2011. Plant extract mediated synthesis of silver and gold nanoparticles and its antibacterial activity against clinically isolated pathogens. Colloids and Surfaces B: Biointerfaces., 85(2), 360-365.
Nanda, A., Saravanan, M., Hil, M.P., 2009. Biosynthesis of silver nanoparticles from Staphylococcus aureus and its ntimicrobial activity against MRSA and MRSE. Nanomed., 5, 452-456.
Nirmala Grace, A., Pandian, K., 2007. Antibacterial efficacy of aminoglycosidic antibiotics protected gold nanoparticles—A brief study Colloids and Surfaces A: Physicochem. Eng. Aspec., 297(1-3), 63-70.
Rai, M., Yadav, A., Gade, A., 2009. Silver nano particles as new generation of antimicrobials. Biotechnol. Adv., 27, 76-83.
Yoon, K., Byeon, J.H., Park, J., Hwang, J., 2007. Susceptibility constants of Escherichia coli and Bacillus subtilis to silver and copper nanoparticles. Sci. Total. Environ., 373, 572-575.