Document Type : Review Article


1 Department of Animal Science, Shahid Bahonar University, Kerman, Iran

2 Young Researchers and Elite Club, Kerman Branch, Islamic Azad University, Kerman, Iran

3 Young Researchers and Elite Club, Sirjan Branch, Islamic Azad University, Sirjan, Iran


Chamomile is a widely recognized herb in Western culture. Its medicinal usage dates back to antiquity where such notables as Hippocrates, Galen, and Asclepius made written reference to it. As part of any medication history, pediatricians always should ask a child’s caregiver about the child’s use of over-the-counter remedies and herbal products. Chamomile is used widely to treat children who have GI disorders such as colic, dyspepsia, and diarrhea and to treat skin conditions such as dermatitis. Clinical studies have demonstrated that chamomile may have a positive effect in the treatment of atopic dermatitis, colic, and diarrhea. There are few adverse effects in children. However, children who are allergic to ragweed, asters, and chrysanthemums should use chamomile with caution.


Adame J, Adame H. Plantas Curativas del Noreste Mexicano. Monterrey, Mexico: Ediciones Castillo; 2000.
Aertgeerts P, Albring M, Klaschka F, Nasemann T et al. Comparative testing of Kamillosan cream and steroidal (0.25% hydrocortisone, 0.75% fluocortin butyl ester) and non-steroidal (5% bufexamac) dermatologic agents in maintenance therapy of eczematous diseases Z Hautkr. 1985; 60(3):270-277.
Aggag ME, Yousef RT. Study of antimicrobial activity of chamomile oil. Planta Med. 1972;22:140–144.
Avallone R, Zanoli P, Puia G. et al. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol. 2000; 59(11):1387-1394.
Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine. 2000;7:273–282.
Cinco M, Banfi E, Tubaro A,. et al. A microbiological survey on the activity of a hydroalcoholic extract of camomile. Int J Drug Res 1983;21:145-151.
Forster DA, Denning A, Wills G, Bolger M, McCarthy E. Herbal medicine use during pregnancy in a group of Australian women. BMC Pregnancy Childbirth. 2006;6:21.
Hausen BM. A 6-year experience with compositae mix. Am J Contact Dermat. 1996;7:94–99.
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57:1221–1227.
Liu ZH, Nakano H. Antibacterial activity of spice extracts against food-related bacteria. Journal of the Faculty of Applied Biological Science, Hiroshima University. 1996;35:181–190.
Mahady GB, Fong HH, Farnsworth N. Flos chamomillae. WHO Monographs on Selected Medicinal Plants. Geneva, Switzerland: World Health Organization Publications; 1999.
Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol. 2001;53: 1323–1329.
McKenna D. Botanical Medicines. The Desk Reference of Major Herbal Supplements. New York, NY: The Haworth Herbal Press 2002.
Nordeng H, Havnen GC. Use of herbal drugs in pregnancy: a survey among 400 Norwegian women. Pharmacoepidemiol Drug Saf. 2004;13:371–380.
Nowack R, Nowak B. Herbal teas interfere with cyclosporine levels in renal transplant patients. Nephrol Dial Transplant. 2005; 20:2554–2556.
Paladíni A Marder M, Viola H, Wolfman C, Wasowski C, Medina JH. Flavonoids and the central nervous system:from forgotten factors to potent anxiolytic compounds. J Pharm Pharmacol 51 (5): 519-526; 1999.
Patzelt-Wenczler R, Ponce-Poschl E. Proof of efficacy of Kamillosan cream in atopic eczema. Eur J Med Res 5 (4): 171-175, 2000.
Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis. 2002;47(4):189-198.
Reider N, Sepp N, Fritsch P, Weinlich G, Jensen-Jarolim E. Anaphylaxis to camomile: clinical features and allergen crossreactivity. Clin Exp Allergy. 2000;30:1436–1443.
Salamon I. Chamomile, a medicinal plant. The Herb, Spice, and Medicinal Plant Digest. 1992;10:1–4.
Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ. 2006;174:1281–1282.
Soliman KM, Badeaa RI. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem Toxicol. 2002;40:1669–1675.