Comparing the Effect of Herbal Mouthwash Made from Pistacia Atlantica Kurdica with Chlorhexidine Mouthwash on Gingival Healing

Abbasi, Naser; Roozegar, Mohamad Ali; Eydi, Siavash

doi:10.48309/ijabbr.2026.2080606.1679

Comparing the Effect of Herbal Mouthwash Made from Pistacia Atlantica Kurdica with Chlorhexidine Mouthwash on Gingival Healing

Articles in Press

Document Type : Original Article

Authors

Naser Abbasi ¹

Mohamad Ali Roozegar ²

Siavash Eydi ²

¹ School of Medicine, Biotechnology and Medicinal Plants Research Center, Ilam University of Medical sciences, Ilam, Iran

² Oral and Dental Health Research Center, Ilam University of Medical Sciences, Ilam, Iran

10.48309/ijabbr.2026.2080606.1679

Abstract

Pistacia atlantica Kurdica, belonging to the Anacardiaceae family, is mainly observed in the mountains of Western Iran. Given the importance of research and the critical role in improving patient health, this study was conducted to compare the effect of an herbal mouthwash derived from wild pistachio fruit with chlorhexidine (CHX) mouthwash on gingival healing following crown lengthening surgery. The present research was a clinical trial in which the statistical population of patients was randomly divided into five groups (n=10) using chlorhexidine mouthwash, herbal mouthwash at concentrations of 1%, 5%, and 10%, and a control group receiving normal saline (NS). The shade-dried fruits were thoroughly ground using a laboratory mill. The resulting dried fruit powder was extracted using the Soxhlet extraction method at the Biotechnology and Medicinal Plants Research Center. For this study, an aqueous-alcoholic extract of the wild pistachio fruit was prepared according to previous studies. The extract was completely dried using a rotary evaporator apparatus at the research center, ensuring complete removal of the solvent. Using the prepared dry extract, the herbal mouthwashes of the wild pistachio fruit were prepared at concentrations of 1%, 5%, and 10%. Fifty individuals were included in this study. Regarding the Parotid Gland Swelling Index (p=0.225) and the Modified Gingival Index (MGI) (P=0.656), the differences between the groups were not statistically significant. According to the Kruskal-Wallis test, the difference in inflammation before and after treatment for the MGI was significant in each of the four intervention groups, and the level of inflammation decreased post-treatment. Furthermore, the difference in plaque levels before and after the use of mouthwashes was significant in each of the five groups, showing a reduction. In alignment with the findings, the application of the Pistacia atlantica Kurdica mouthwash led to gingival healing after crown lengthening surgery. Therefore, the prescription of this agent is recommended.

Graphical Abstract

Keywords

Pistacia Atlantica Kurdica

Chlorhexidine

Gum Healing

Subjects

Pharmacology

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