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Effect of Hydro-Methanolic Extract of Xylopia Aethiopica on Sexual Behaviour in Male Wister Rats
Document Type : Original Article
Authors
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, Port Harcourt Nigeria
Abstract
This study aims to investigate the effect of xylopia aethiopica on the sexual behavior of adult male rats. Fort eight adult male wistar rats were used for the study. They were randomly divided into four groups of 6 animals each: group 1 was control, while groups 2, 3 and 4 were test groups treated daily with 0.5, 2 and 10 mg/kg body weight respectively of hydro-methanolic fruit extract of xylopia aethiopice for 30 consecutive days followed by 30 days recovery. Mating test was performed on six animals from each group on days 30 and 60 of the study. Also, 6 animals were sacrificed from each group and blood collected for serum testosterone assay on 31st and 61st days of the study. Results show significant (P<0.05) dose dependent increase in ejaculation latency (EL), and post ejaculatory interval (PEI) with significant decrease (P<0.05) in ejaculation frequency (EF) and in serum testosterone levels in rats in all the test groups. We conclude that xylopia aethiopice enhances copulatory performance without altering sexual excitement, arousal and motivation; therefore could be useful in the management of male sexual dysfunction
Keywords
Subjects
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Beach FA. (1956). Characteristic of masculine ‘‘sex drive’’. In: Jones MR (ed). Nebraska Symposium on Motivation. Press Lincoln: University of Nebraska, pp 1 – 31.
Boyom FF, Ngouana V, Zollo PH, Menut C, Bessiere JM, Gut J,( 2003). Rosenthal PJ: Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. Phytochemistry, 64:1269.
Breitbart H.; Rubinstein S.; Nass- Arden L. (1984). Effect of gossypol acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. Int. J. Androl. 7: 439-447
Burkhills, H.M.,(1985) Useful plants of West Tropical Africa, 2nd edi Royal botanical garden vol 1 Pp130-132
Carani C, Bancroft J, Granata A, Del Rio G, Marrama P. (1992).Testosterone and erectile function, nocturnal penile tumescence and rigidity and response to erotic stimuli in hypogonadal and eugonadal men. Neuropsychoendocrinology;17:647–92.
Dewsbury DA, Davis HN Jr: (1970). Effect of Reserpine on the copulatory behaviour of male rats. Physiol Behav, 5:1331-1333.
Esuoso KO, Odetoun SM (2005). Proximate Chemical Composition and Possible industrial Utilization of Blighia sapida seed and oils. J. Phytotherapy Res., 72(7): 311 – 313.
Everitt, B.J. (1990.). Sexual motivation: a neural and behavioral analysis of the mechanisms underlying appetitive and copulatory responses of male rats. Neurosci. Biobehav. Rev. 14: 217-232,
Fleischer TC, Mensah ML, Mensah AY, Komlaga G, Gbedema SY, Skaltsa H(2008): Antimicrobial activity of essential oils of Xylopia aethiopica. Afr J Tradit Complement Altern Med, 5:391.
Gauthaman K, Adaikan PG & Prasad RNY (2002). Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sciences 71 1385–1396.
Hull, E.M., Meisel, R.L. and Sachs, B.D (2002) Male sexual behavior. In: Hormones, Brain and Behavior, edited by Pfaff, D., Arnold, A.P., Etgen, A.M., Fahrbach, S.E. and Rubin, R.T. New York, NY, USA: Academic Press, vol. 1, pp. 3-137.
Hull, E.M., Wood, R.I. and McKenna, K.E (2006). Neurobiology of male sexual behavior. In: Knobil and Neill’s Physiology of Reproduction, 3rd ed., edited by Neill, J.D. San Diego, CA, USA: Elsevier Press, pp. 1729-1824.
Konning GH, Agyare C, Ennison B (2004): Antimicrobial activity of some medicinal plants from Ghana. Fitoterapia, 75:65.
Kuete V (2010): Potential of Cameroonian plants and derived products against microbial infections: a review. Planta Med, 76:1479.
Paola Zanoli, Augusta Benelli, Manuela Zavatti, Marianna Rivasi, Claudia Baraldi, Mario Baraldi (2008).
Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implications. Asian J Androl; 10 (6): 937–945
Randel R. D; Chase C.C.Jr. and Wyse S.J.(1992). Effects of gossypol and cottonseed products on reproduction of mammals. J. Anim. Sci. 70. 1628
Sachs, B.D. and Meisel, R.L. (1988). The physiology of male sexual behavior. In: The Physiology of Reproduction, edited by Knobil, E. and Neill, J. New York: Raven Press, pp. 1393-1458.
Szechtman H, Moshe H, Rabi S (1981): Sexual behaviour Pain sensitivity and stimulates endogenous opioid in male rats. Eur J Pharmacol, 70:279-285.
Tairu AO, Hofmann T, Schieberle P. (1999). Identification of the key aroma compounds in dried fruit of Xylopia aethiopica. In: J. Janick (ed.), Perspectives on new crops and new uses. ASHS Press, Alexandria, VA. p. 474– 478.
Tajuddin, A; Ahmad, S; Latif, A and Qasmi, I. A (2004). “Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats,” BMC Complementary and Alternative Medicine, vol. 4, pp. 17–24.
Zanoli P, Benelli A, Rivasi M, Baraldi C, Vezzalini F, Baraldi M.( 2003). Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats. Int J Impot Res; 15:450–5.
Adienbo OM, Nwafor A and Iwuji S (2011). Effect of aqueous fruit extract of xylopia aethiopica on Reproductive hormones in male guinea pigs. Global journal of pure and applied sciences. Vol 17 (2) 137-139.
Agmo A. (1997) Male rat sexual behaviour. Brain Res Prot; 1: 203–9.
Amin KMY, Khan MN, Rahman SZ, Khan NA (1996): Sexual function improving effect of Mucuna pruriens in sexually normal male rats. Fitoterapia, 67:53-58.
Beach FA. (1956). Characteristic of masculine ‘‘sex drive’’. In: Jones MR (ed). Nebraska Symposium on Motivation. Press Lincoln: University of Nebraska, pp 1 – 31.
Boyom FF, Ngouana V, Zollo PH, Menut C, Bessiere JM, Gut J,( 2003). Rosenthal PJ: Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. Phytochemistry, 64:1269.
Breitbart H.; Rubinstein S.; Nass- Arden L. (1984). Effect of gossypol acetic acid on calcium transport and ATPase activity in plasma membranes from ram and bull spermatozoa. Int. J. Androl. 7: 439-447
Burkhills, H.M.,(1985) Useful plants of West Tropical Africa, 2nd edi Royal botanical garden vol 1 Pp130-132
Carani C, Bancroft J, Granata A, Del Rio G, Marrama P. (1992).Testosterone and erectile function, nocturnal penile tumescence and rigidity and response to erotic stimuli in hypogonadal and eugonadal men. Neuropsychoendocrinology;17:647–92.
Dewsbury DA, Davis HN Jr: (1970). Effect of Reserpine on the copulatory behaviour of male rats. Physiol Behav, 5:1331-1333.
Esuoso KO, Odetoun SM (2005). Proximate Chemical Composition and Possible industrial Utilization of Blighia sapida seed and oils. J. Phytotherapy Res., 72(7): 311 – 313.
Everitt, B.J. (1990.). Sexual motivation: a neural and behavioral analysis of the mechanisms underlying appetitive and copulatory responses of male rats. Neurosci. Biobehav. Rev. 14: 217-232,
Fleischer TC, Mensah ML, Mensah AY, Komlaga G, Gbedema SY, Skaltsa H(2008): Antimicrobial activity of essential oils of Xylopia aethiopica. Afr J Tradit Complement Altern Med, 5:391.
Gauthaman K, Adaikan PG & Prasad RNY (2002). Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sciences 71 1385–1396.
Hull, E.M., Meisel, R.L. and Sachs, B.D (2002) Male sexual behavior. In: Hormones, Brain and Behavior, edited by Pfaff, D., Arnold, A.P., Etgen, A.M., Fahrbach, S.E. and Rubin, R.T. New York, NY, USA: Academic Press, vol. 1, pp. 3-137.
Hull, E.M., Wood, R.I. and McKenna, K.E (2006). Neurobiology of male sexual behavior. In: Knobil and Neill’s Physiology of Reproduction, 3rd ed., edited by Neill, J.D. San Diego, CA, USA: Elsevier Press, pp. 1729-1824.
Konning GH, Agyare C, Ennison B (2004): Antimicrobial activity of some medicinal plants from Ghana. Fitoterapia, 75:65.
Kuete V (2010): Potential of Cameroonian plants and derived products against microbial infections: a review. Planta Med, 76:1479.
Paola Zanoli, Augusta Benelli, Manuela Zavatti, Marianna Rivasi, Claudia Baraldi, Mario Baraldi (2008).
Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implications. Asian J Androl; 10 (6): 937–945
Randel R. D; Chase C.C.Jr. and Wyse S.J.(1992). Effects of gossypol and cottonseed products on reproduction of mammals. J. Anim. Sci. 70. 1628
Sachs, B.D. and Meisel, R.L. (1988). The physiology of male sexual behavior. In: The Physiology of Reproduction, edited by Knobil, E. and Neill, J. New York: Raven Press, pp. 1393-1458.
Szechtman H, Moshe H, Rabi S (1981): Sexual behaviour Pain sensitivity and stimulates endogenous opioid in male rats. Eur J Pharmacol, 70:279-285.
Tairu AO, Hofmann T, Schieberle P. (1999). Identification of the key aroma compounds in dried fruit of Xylopia aethiopica. In: J. Janick (ed.), Perspectives on new crops and new uses. ASHS Press, Alexandria, VA. p. 474– 478.
Tajuddin, A; Ahmad, S; Latif, A and Qasmi, I. A (2004). “Effect of 50% ethanolic extract of Syzygium aromaticum (L.) Merr. & Perry. (clove) on sexual behaviour of normal male rats,” BMC Complementary and Alternative Medicine, vol. 4, pp. 17–24.
Zanoli P, Benelli A, Rivasi M, Baraldi C, Vezzalini F, Baraldi M.( 2003). Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats. Int J Impot Res; 15:450–5.
Volume 1, Issue 9 - Serial Number 9
September and October 2013Pages 1078-1085
- Receive Date 18 August 2014
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