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Assessment the Effect of Kidney Internal Structure on Gamma Absorbed Dose of Radiopharmaceutical 111In-DTPA
Document Type : Original Article
Author
Physics department, Faculty of Shahid Chamran, Technical and Vocational University, Kerman, Iran
Abstract
Large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. Therefore, radiation unwanted dose is created in kidney. As a result, exact calculation of prescribed radiopharmaceuticals amount is important. Monte Carlo method is used for simulation of radiation transport in body due to random nature of radiation. In this research, for the first time kidney is considered integrated and for the second time it is considered that it has three areas; gamma absorbed dose is calculated and compared in cortex and medulla kidney using MCNPX code to identify a more accurate way to prescribe radioisotope. The results showed that gamma absorbed dose in medulla is 2 times as much as dose in integrated kidney and gamma dose in cortex is about 62% as much as dose in integrated kidney. Internal structure of kidney should be considered in simulation to achieve a more accurate prescribed dose
Keywords
Blachot J (1996). LBNL Isotopes Project - LUNDS University. ŘTable of Radioactive Isotopes. Version 2.1. The website: http://ie.lbl.gov/toi/nuclide.asp?iZA=490111
Bouchet LG, Bloch WE, Blanco HP, Wessels BW, Siegel JA, Rajon DA, Clairand I,Sgouros G (2003).
Absorbed Fractions and Radionuclide S Values for Six Age-Dependent Multiregion Models of the Kidney .MIRD PAMPHLET NO. 19.J Nucl Med :44:1113-1147.
Briesmeister JF (2000). MCNP A general Monte Carlo N-particle transport code, Version 4C, Los Alamos.
Cristy M, Eckerman KF (1987).specific absorbed fractions of energy at various ages from internal photon source.
ICRP,(1988). Radiation Dose to Patients from Radiopharmaceuticals.ICRP Publication 53.Ann.ICRP 18(1-4).
Kalantar Hormozi M, Nabipour I, Assadi M, Asadipouya K, Zendehboudi S, Ranjbar Omrani G. (2011).
Subclinical Hypothyroid. ISMJ; 14 (1):51-60.
Konijnenberg M, Melis M, Valkema R, Krenning E, Jong M (2007).Radiational dose distribution in human kidneys by octreotides in peptide receptor radionuclide therapy. J Nucl Med; 48:134-142.
Los Alamos National Laboratory (2002).MCNPX Users manual. version 2.4.0.
Mansourbahmani M, Moussavi AH, Vakili A, Rezaie MR, Dehghan HR, Rezvan Najad E (2013). Study of Existing Radon In Milk and Its Effect on Body Organs. Int J Adv Biol Biom Res; 1(8): 802-812.
Mirzaei M, Mowlavi AA, Mirshekarpour H, Mohammadi S (2012). Absorbed dose calculation from gamma and gamma rays of I-131 in ellipsoidal thyroid and other organs of neck with MCNPX code, Iranian South Med J, 3:201-7.
Mirzaei M, Mirshekaipour H(2013a). Comparison of absorbed fraction of Gamma and Beta rays of I-124 and I-131radio-isotopes in thyroid gland with Monte Carlo Simulation. Int J Adv Biol Biom Res; 1(9):993-998.
Mirzaei M(2013b). Studying the effect of kidney internal structure on beta absorbed dose of radiopharmaceuticals Hg-203, Ho-166 and Y-90 using Monte Carlo. Int J Adv Biol Biom Res; 1(9):1040- 1046.
Mowlavi AA , Mokhtarinejad E (2006). Dose Calculation Due to a 125I Source Model 6711 and Determination of Its Dosimetry Parameters in Water and Soft Tissue Phantom, Iranain Journal of Medical Physics, Vol.3 ,No.12.
Mowlavi AA (2008).Monte Carlo Dose Calculation of 90Sr/90Y Source in Water Phantom, Iranian Journal of Medical Physics, Vol.5, No.1 (18-19).
Soniua M, Eman M, Magda SH, Ibrahem I, Esmat AA (2006). Monte carlo dose calculations for breast radiotherapy using co-60 gamma rays .Journal of Nuclear and radiation Physics 1[1]: 61-72.
Wessels BW, Konijnenberg MW, Dale RG, Breitz HB, Cremonesi M, Meredith AJ, Green AJ, Bouchet LG, Brill AB, Bloch WE, Sgouros G, Thomas S (2008). The Effect of Model Assumptions on Kidney Dosimetry and Response—Implications for Radionuclide Therapy.J Nucl Med 49:1884-1899.
Zarei M, Kalifzadeh F(2013). Effects of using radiation processing in nutrition science and their restriction: a review. Int J Adv Biol Biom Res; 1(3):222-231.
Bouchet LG, Bloch WE, Blanco HP, Wessels BW, Siegel JA, Rajon DA, Clairand I,Sgouros G (2003).
Absorbed Fractions and Radionuclide S Values for Six Age-Dependent Multiregion Models of the Kidney .MIRD PAMPHLET NO. 19.J Nucl Med :44:1113-1147.
Briesmeister JF (2000). MCNP A general Monte Carlo N-particle transport code, Version 4C, Los Alamos.
Cristy M, Eckerman KF (1987).specific absorbed fractions of energy at various ages from internal photon source.
ICRP,(1988). Radiation Dose to Patients from Radiopharmaceuticals.ICRP Publication 53.Ann.ICRP 18(1-4).
Kalantar Hormozi M, Nabipour I, Assadi M, Asadipouya K, Zendehboudi S, Ranjbar Omrani G. (2011).
Subclinical Hypothyroid. ISMJ; 14 (1):51-60.
Konijnenberg M, Melis M, Valkema R, Krenning E, Jong M (2007).Radiational dose distribution in human kidneys by octreotides in peptide receptor radionuclide therapy. J Nucl Med; 48:134-142.
Los Alamos National Laboratory (2002).MCNPX Users manual. version 2.4.0.
Mansourbahmani M, Moussavi AH, Vakili A, Rezaie MR, Dehghan HR, Rezvan Najad E (2013). Study of Existing Radon In Milk and Its Effect on Body Organs. Int J Adv Biol Biom Res; 1(8): 802-812.
Mirzaei M, Mowlavi AA, Mirshekarpour H, Mohammadi S (2012). Absorbed dose calculation from gamma and gamma rays of I-131 in ellipsoidal thyroid and other organs of neck with MCNPX code, Iranian South Med J, 3:201-7.
Mirzaei M, Mirshekaipour H(2013a). Comparison of absorbed fraction of Gamma and Beta rays of I-124 and I-131radio-isotopes in thyroid gland with Monte Carlo Simulation. Int J Adv Biol Biom Res; 1(9):993-998.
Mirzaei M(2013b). Studying the effect of kidney internal structure on beta absorbed dose of radiopharmaceuticals Hg-203, Ho-166 and Y-90 using Monte Carlo. Int J Adv Biol Biom Res; 1(9):1040- 1046.
Mowlavi AA , Mokhtarinejad E (2006). Dose Calculation Due to a 125I Source Model 6711 and Determination of Its Dosimetry Parameters in Water and Soft Tissue Phantom, Iranain Journal of Medical Physics, Vol.3 ,No.12.
Mowlavi AA (2008).Monte Carlo Dose Calculation of 90Sr/90Y Source in Water Phantom, Iranian Journal of Medical Physics, Vol.5, No.1 (18-19).
Soniua M, Eman M, Magda SH, Ibrahem I, Esmat AA (2006). Monte carlo dose calculations for breast radiotherapy using co-60 gamma rays .Journal of Nuclear and radiation Physics 1[1]: 61-72.
Wessels BW, Konijnenberg MW, Dale RG, Breitz HB, Cremonesi M, Meredith AJ, Green AJ, Bouchet LG, Brill AB, Bloch WE, Sgouros G, Thomas S (2008). The Effect of Model Assumptions on Kidney Dosimetry and Response—Implications for Radionuclide Therapy.J Nucl Med 49:1884-1899.
Zarei M, Kalifzadeh F(2013). Effects of using radiation processing in nutrition science and their restriction: a review. Int J Adv Biol Biom Res; 1(3):222-231.
Volume 1, Issue 9 - Serial Number 9
September and October 2013Pages 1094-1100
- Receive Date 18 August 2014
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