Document Type : Original Article
1 Department of Avian Medicine, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
2 Graduate student, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
Objective: In recent years, antibiotics have been used widely in the glob to prevent and treat bacterial diseases. They injected into eggs to eliminate pathogens and prevention of egg transmission of disease, but the adverse effects of drugs have always been a major concern. There is little information available about the safety of tetracycline drugs in the embryonated eggs of the birds. The objective of this study was to evaluation of the effect of doxycycline on the viability of the quail embryo during the first trimester of the incubation period. Methods: Fertile quail eggs were divided into two equal treatment groups. The uninjected group and doxycycline-injected group whose individuals were injected with doxycycline injectable solution at a dosage of 10 mg per Kg egg-weight. Embryos monitored daily during incubation until day 6 after which; they were examined for viability. Results: Results showed that 72% of embryos were alive in the doxycycline-injected group. Based on findings, it is concluded that doxycycline at above-mentioned concentration has no severe lethal effect on the quail embryo. So, doxycycline egg-injection can be used toeliminate pathogens and prevention of egg transmission of the disease.
Ahrens FA, Martin RJ (2013). Antimicrobial drugs. Handbook of Veterinary Pharmacology 347.
Altunsoy A, Aypak C, Azap A, Ergˆn¸l ÷, Bal˝k › (2011). The impact of a nationwide antibiotic restriction program on antibiotic usage and resistance against nosocomial pathogens in Turkey. Int. j. med. Sci. 8(4):339.
Banerjee S, Mukhopadhayay SK, Ganguly S (2013). Phytogenic Growth Promoter as Replacers for Antibiotic Growth Promoter in Poultry Birds. J. Anim. Genet. Res.1(1): 6-7.
Buscaglia C (2013). Influence of the addition of antibiotics on survival of herpevirus of turkeys. Avian Dis. 52(2): 437-436.
Colomer-Lluch M, Imamovic L, Jofre J, Muniesa M (2011). Bacteriophages carrying antibiotic resistance genes in fecal waste from cattle, pigs, and poultry. Antimicrob. Agents. Chemother. 55(10): 4908-4911.
Crespo R, Shivaprasad H, Silva Franca M (2013). Ulcerative Enteritis-like Disease Associated with Clostridium sordellii in Quail. Avian Dis. 57(3): 213-221.
Ghazikhanian GY, Yamamoto R, McCapes R, Dungan WM, Larsen C, Ortmayer H (1980). Antibiotic Egg Injection to Eliminate Disease II. Elimination of Mycoplasma meleagridis from a Strain of Turkeys. Avian Dis. 48-56.
Hamburger V (1942). A manual of experimental
embryology, University of Chicago Press Chicago.235- 268.
2393 Tavakkoli & Noori Gooshki / Int. J. Adv. Biol. Biom. Res, 2014; 2 (8),2390-2394
Hasan B, Faruque R, Drobni M, Waldenstrˆm J, Sadique A, Ahmed KU, Islam Z, Parvez MH, Olsen B, Alam M (2011). High prevalence of antibiotic resistance in pathogenic Escherichia coli from large-and small-scale poultry farms in Bangladesh. Avian Dis. 55(4): 689-692.
Jones K, Thornton J, Zhang Y, Mauel M (2013). A 5-year retrospective report of Gallibacterium anatis and Pasteurella multocida isolates from chickens in
Mississippi. Poult. Sci. 92(12): 3166-3171.
Kabir S (2010). Avian colibacillosis and salmonellosis: a closer look at epidemiology, pathogenesis, diagnosis, control and public health concerns. Int. J. Environ. Res. Public. Health 7(1): 89-114.
Kleven S (2008). Control of avian mycoplasma infections in commercial poultry. Avian Dis. 52(3): 367-374.
Lee K-W, Ho Hong Y, Lee S-H, Jang SI, Park M-S, Bautista DA, Donald Ritter G, Jeong W, Jeoung H-Y, An D-J (2012). Effects of anticoccidial and antibiotic growth promoter programs on broiler performance and immune status.
Res. Vet. Sci. 93(2): 721-728.
Lee S-K, Chon J-W, Song K-Y, Hyeon J-Y, Moon J-S, Seo K-H (2013). Prevalence, characterization, and antimicrobial susceptibility of Salmonella Gallinarum isolated from eggs produced in conventional or organic farms in South Korea. Poult. Sci. 92(10): 2789-2797.
MacDonald JM, Wang S-L (2011). Foregoing subtherapeutic antibiotics: The impact on broiler grow-out operations. App. Eco. Perspect. Policy 33(1): 79-98.
McCapes R, Yamamoto R, Ghazikhanian G, Dungan W, Ortmayer H (1977). Antibiotic Egg Injection to Eliminate Disease I. Effect of Injection Methods on Turkey Hatchability and Mycoplasma meleagridis Infection. Avian Dis. 57-68.
McDougald L, Abraham M, Beckstead R (2012). An Outbreak of Blackhead Disease (Histomonas meleagridis) in Farm-Reared Bobwhite Quail (Colinus virginianus). Avian Dis. 56(4): 754-756.
Mosallanejad S, Tavakkoli H, Derakhshanfar A, S S (2014a). Efficiency of the injection of trimethoprim/sulfamethoxazole solution on game bird
embryonated-egg during the late stage of development. Int. J. Adv. Biol. Biom. Res. 2(5): 1553-1561.
Mosallanejad S, Tavakkoli H, Derakhshanfar A, S S (2014b). An experimental study of the systemic alteration of nitroimidazoles in the middle stage of
embryonic development. Int. J. Adv. Biol. Biom. Res. 2(5): 1468-1474.
Nascimento ER, Pereira V, Nascimento M, Barreto M (2005). Avian mycoplasmosis update. Revista Brasileira CiÍncia. AvÌcola. 7(1): 1-9.
Nemati M (2013). Antimicrobial resistance of porteus isolates from poultry. Euro. J. Exp. Bio. 3(6): 499-500.
Obeng AS, Rickard H, Ndi O, Sexton M, Barton M (2012). Antibiotic resistance, phylogenetic grouping and virulence potential of Escherichia coli isolated from the faeces of intensively farmed and free range poultry. Vet. Microbiol. 154(3): 305-315.
J. Livestock Product. 3(2): 21-24.
Rigobelo EC, Blackall PJ, Maluta RP, £vila FAd (2013). Identification and antimicrobial susceptibility patterns of Pasteurella multocida isolated from chickens and japanese quails in Brazil. Braz J. Microbiol. 44(1): 161-164.
Sapkota AR, Hulet RM, Zhang G, McDermott P, Kinney EL, Schwab KJ, Joseph SW (2011). Lower prevalence of antibiotic-resistant enterococci on US conventional poultry farms that transitioned to organic practices.
Environ. Health Perspect. 119(11): 1622.
Sheeks OB, Sheeks RL (1992). Egg injection method, apparatus and carrier solution for improving hatchability and disease control, Google Patents.
Singroha R, Srivastava S, Chhikara P (2012). Effect of Gentamicin on kidney in developing chicks. Eur. J. Anat. 16(2): 119-126.
Singroha R, Srivastava S, Chhikara P (2013). Effect of gentamicin on proximal convoluted tubules of kidney in developing chicks. J. Anat. Soc. India 62(1): 17-22.
Swayne D, Glisson JR, McDougald L, Nolan LK, Suarez DL, Nair VL (2013). Diseases of Poultry, Wiley-Blackwell. Sweetman SC, Pharm B, PharmS F, Eds. (2009). Martindale: The Complete Drug Reference. London, Pharmaceutical Press.
Tavakkoli H, Derakhshanfar A, Noori Gooshki S (2014a). Toxicopathological lesions of fosfomycin in embryonic model. Euro. J. Exp. Bio. 4(2): 63-71.
Tavakkoli H, Derakhshanfar A, S S (2014b). Toxicology of urotropine in chicken embryo model. OJVR 18(2): 109-115.
Tavakkoli H, Derakhshanfar A, Salandari S (2104). Investigation on the using of linco-spectin solution for in ovo administration in chicken embryo. Int. J. Adv. Biol. Biom. Res. 2(1)