International Journal of Advanced Biological and Biomedical Research

Effects of Hydroalcoholic Extract of Hypericum Perforatum on the Spermatogenesis of BALB/c Male Mice Treated by Cyclophosphamide

Diba Zare; Fariba Ghalebi; Mina Ramezani; Parvin Torabzadeh

Volume 10, Issue 4 , October 2022, , Pages 253-261

https://doi.org/10.22034/ijabbr.2022.560023.1415

Abstract

Background: Hypericum perforatum is a flowering plant from the Hypericaceae family. This herb has warm and dry nature based on traditional medicine and includes many healing properties ... Read More Background: Hypericum perforatum is a flowering plant from the Hypericaceae family. This herb has warm and dry nature based on traditional medicine and includes many healing properties like noticeable effects on mild and moderate depression cases. Cyclophosphamide is used to treat various types of cancers and autoimmune diseases with the side effect of fertility reduction. We studied the effects of hydroalcoholic extract of Hypericum perforatum on the spermatogenesis process of cyclophosphamide-treated male mice. Methods: In this experimental study, 70 adult BALB/c male mice weighing 26-28 g were randomly divided into 7 groups of 10, including, a control group (no injection), a sham group (normal saline), and three experimental groups which were treated with 5 mg/kg body weight of cyclophosphamide and also, doses of 50, 100, and 150 mg/kg body weight of hydroalcoholic extract, respectively. In addition, a cyclophosphamide group (5 mg/kg body weight) and an extract group (100 mg/kg body weight) were evaluated. All the injections were performed intraperitoneally for 10 consecutive days. After two weeks, blood samples were collected for a testosterone level examination. Testes and epididymis were removed for tissue sectioning and were stained with the H&E method. Data were analyzed using one-way ANOVA and Tukey post-hoc test. Results: Results indicated that taking 5 mg/kg body weight of cyclophosphamide decreased mouse and testis weight and had a detrimental effect on the spermatogenesis process in the way that spermatogenic cell counts, and seminiferous and epididymis tubules diameter were decreased in comparison with the control and sham groups. But 100 and 150 mg/kg body weight doses of the extract with 5 mg/kg body weight of cyclophosphamide showed a significant increase (P≤0.05 and p≤0.01) on the mentioned parameters compared to the positive control group. Conclusion: Therefore, it seems that the main component in this herb such as hypericin could decrease the detrimental effects of cyclophosphamide on mouse fertility.

Evaluation of antibacterial activity of aqueous and ethanol extracts of Rumex alveollatus against Klebsiella pneumoniae

Gholamreza Mansouri; Neda Sadat Khademestarki; Ciamak Ghazaei; Mohadeseh Zarei-Yazdei

Volume 10, Issue 4 , October 2022, , Pages 262-270

https://doi.org/10.22034/ijabbr.2022.554941.1400

Abstract

Introduction: Antimicrobial resistance in Klebsiella pneumoniae has been on the increase over the years Therefore, numerous endeavors have been carried out so as to discover another ... Read More

Resistance of Egyptian Field Populations of Spodoptera littoralis (Lepidoptera: Noctuidae) to Emamectin Benzoate and Role of Detoxification Enzymes

Seham Mansour Ismail

Volume 10, Issue 4 , October 2022, , Pages 277-287

https://doi.org/10.22034/ijabbr.2022.562491.1418

Abstract

Background: One of the most significant pests that harm numerous agricultural crops ‎is the cotton leafworm Spodoptera littoralis (Boisduval) and it has evolved resistance ‎to ... Read More

Evaluation of Ferulic Acid (FA) Effects on Testicular Tissue ‎and Sperm Parameters in Rats with Lead Toxicity

Farzaneh Fazeli; Parisa Hasanein

Volume 10, Issue 3 , July 2022, , Pages 208-218

https://doi.org/10.22034/ijabbr.2022.556101.1403

Abstract

Introduction: Lead is one of the environmental pollutants and it is among the most important causes of oxidative stress in biological tissues. In this study, the effects of lead acetate ... Read More Introduction: Lead is one of the environmental pollutants and it is among the most important causes of oxidative stress in biological tissues. In this study, the effects of lead acetate on testicular tissue destruction were investigated. Ferulic acid (FA), which is an antioxidant and reduces free radicals, is expected to be effective in improving testicular function in lead-infected rats.Materials and methods: For this study, 24 white male Wistar rats, categorized in four groups: control, lead acetate toxicity, FA control, and lead-Ferulic Acetate, were treated in the laboratory for 56 days. At the end of the treatment period, the rats were anesthetized and after blood sampling, they were analysed. Then, histological analysis was performed after testicular resection. To evaluate sperm characteristics, the distal part of the testicular epididymis was finally cut and fragmented.Research Findings: In examination of testicular tissue sections in the samples, it was observed that the mean diameter of seminiferous tubules in samples with lead acetate poisoning was decreased more than the control, whereas in the group with FA treatment, the diameter was increased. Increased bleeding in the space between seminiferous tubules and tissue vacuolation were also recorded in the lead acetate group, but it was improved in the treatment group. The number, motility, percentage of normal sperm, and survival percentage of sperm which had a significant decrease in the lead acetate group, and were increased in the FA-treated group. Likewise, testosterone levels, which had a significant drop in the lead acetate poisoning group, were increased in FA-treated group.Discussion: The result showed that lead acetate, with its destructive effects on testicular tissue, reduces the number of healthy and mature sperms, and ultimately leads to mice fertility of these mice, but ferulic acid which acts as an antioxidant has recovery effects against lead acetate.

Investigation of Advisors' Performance and Students' ‎Satisfaction of Universities of Medical Sciences: A ‎Systematic Review ‎

khalil komlakh; Hosein Karimiyarandi

Volume 10, Issue 3 , July 2022, , Pages 229-236

https://doi.org/10.22034/ijabbr.2022.559946.1414

Abstract

Background: Increasing the satisfaction of students with the advisors can help to improve the educational status of students. Therefore, this study aimed to investigate the performance ... Read More

An Investigation on Prevalence of Side Effects of a ‎New Pentavalent Vaccine in Two-to Six-Month-Old ‎Children Referred to Health Centers in Ilam City ‎

Jasem Mohammadi; Mina Mamizadeh; Saeid Lotfalivan

Volume 10, Issue 3 , July 2022, , Pages 237-244

https://doi.org/10.22034/ijabbr.2022.557134.1408

Abstract

Background and Objective: Vaccines are medical devices used for boosting the health of people, especially children. This study was performed to determine the prevalence of the side ... Read More Background and Objective: Vaccines are medical devices used for boosting the health of people, especially children. This study was performed to determine the prevalence of the side effects of a new pentavalent vaccine in 2- to 6-month-old children in Ilam.Materials and Methods: This descriptive cross-sectional study was performed on 2-6-month-old children for inoculating the pentavalent vaccine. A questionnaire containing queries on the age of child, parents’ education, contact number, injection date, gestational age, the underlying diseases, failure to thrive (FTT), and side effects (diarrhea, vomiting, nausea, redness, fever, intense crying, restlessness, drowsiness, stiffness, etc.).Results: Of the children, 35.9% were two months old, 31.8% were four months old, and 32.3% were six months old. Boys and girls constituted 53% and 47% of children, respectively. Regarding mothers’ education, 54.5% had lower than diploma degrees, and 6.1% had academic education. Regarding fathers’ education, 13.2% had lower than diploma, and 12% had academic degrees. Most of the children (94.4%) had no underlying diseases, and 5.6% of them suffered from the underlying diseases including reflux (1.6%), anemia (2.3%), favism (0.9%), fever and convulsion (0.7%), and hypothyroidism (0.2%). The most common complications were fever (68.1%), skin redness (56.1%), pain (43.8%), and restlessness (24.7%). Fever (69.2% vs. 66.8%, P>0.05), skin redness (65.2% vs. 45.8%, P<0.05), vomiting (10.5% vs. 3.3%, P<0.05), and stiffness (6.6% vs. 3.3%, P>0.05) were more common in boys than girls, respectively. On the other hand, restlessness (35.8% vs. 14.8%, P<0.05) was significantly higher in girls than in boys.Conclusion: According to our results, fever, skin redness, and pain were the most common complications. Fever was more common in 2-month-old boys, and pain was more observed in 6-month-old girls. Most of the side effects were transient and disappeared upon a week. No remarkable contraindications were reported, confirming the safety of the vaccine.

Iranian Medicinal Plants: From Economically to Ethnomedicine Studies

Ali Salehi Sardoei

Volume 10, Issue 2 , April 2022, , Pages 98-116

https://doi.org/10.22034/ijabbr.2022.540138.1369

Abstract

Introduction: Iran is a privileged country with a high rank in plant biodiversity, including 11 of the 13 globally known climates. According to botanists and researchers, there are ... Read More

Monte Carlo Investigation of Organs Activation in ‎Proton‏ ‏and Heavy Ions Cancer Therapy by Spallation ‎Process

Mohammad Reza Rezaie; Ali Nouraddini Shahabadi; Saeed Mohammadi

Volume 10, Issue 2 , April 2022, , Pages 117-125

https://doi.org/10.22034/ijabbr.2022.549880.1385

Abstract

Background: High-energy heavy ions and protons produced by accelerators are used in industrial and medical applications. Recently, Helium (He), Argon (Ar), Krypton (Kr), Carbon (C) ... Read More

Radiation Hazards Investigation of Jooshan Hot Spring in Kerman Province

Mahmoud Abdollahpour; Mohammad Reza Rezaie; Neda Zareie; Saeed Mohammadi

Volume 10, Issue 2 , April 2022, , Pages 164-172

https://doi.org/10.22034/ijabbr.2022.550713.1389

Abstract

Introduction: Hot spring water is used for health and medical treatment. Hot spring water, when passing underground rocks, is contaminated with radioactive materials and water soluble ... Read More

Role of Immunity Booster Diet, Spices and Herbs, Change Lifestyle: Medical Viewpoints in COVID-19

Saad Alghamdi; Mohammad Asif

Volume 10, Issue 1 , February 2022, , Pages 18-31

https://doi.org/10.22034/ijabbr.2021.537187.1365

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a pandemic caused by a novel coronavirus. On 30 January 2020, the first case of the COVID-19 was reported in India and it affects ... Read More Background: Coronavirus disease 2019 (COVID-19) is a pandemic caused by a novel coronavirus. On 30 January 2020, the first case of the COVID-19 was reported in India and it affects the whole world. The impact of various nutrients on the human immune system. To defend itself, the human body has numerous components. The human immune system identifies molecules that are foreign to its structure and responds to them in a useful manner. When a pathogen factor enters the human body, the immune system responds by triggering an immunological response. Methods: Symptoms of COVID-19 may vary from a mild cold to severe respiratory problems and fatality. The symptom may appear in 2 days or as long as 14 days after making contact with the COVID-19 patient. Results: To avoiding contact with an infected person, regular hand washing, wearing a mask may help to prevent and control the COVID-19. There is no specific therapy available for COVID-19. The best way is to prevent infection is to avoid being exposed to the COVID-19. Nutrition is one of the numerous variables that influence immune system function. There is a link between the immune system and nutrition, and malnutrition should not be seen just as a calorie and protein shortage. Conclusions: The body's defensive system should be reinforced to boost immunity, minimize illness risks, and maintain good health. Healthy eating, regular exercise, and an immunological diet, on the other hand, will be a more cost-effective and natural choice.Due to these reasons, the main aim of nourishment is not merely to gain energy andprotein, but to enhance resistance against ailments with some specific nutriment and to turn the inflammatory responsein someone’s best interests. The nutriments which show beneficial effects on the immune system are called immune nutrients and nourishment on these nutriments is called immune diet. The main fields of application of immune diet are patients undergoing surgery, traumatized, cancer, patients who need intensive care, and patients with serious infections.

Review on Iranian Medicinal Plants with anticancer Properties

Ali Salehi Sardoei

Volume 10, Issue 1 , February 2022, , Pages 44-56

https://doi.org/10.22034/ijabbr.2021.540129.1368

Abstract

Introduction: Cancer is abnormal and uncontrolled cell proliferation. Carcinogens cause DNA damage and loss of function of tumor suppressor genes, resulting in tumor formation and metastasis. ... Read More

Composition of essential oil of Dorema aucheri Boiss. and Allium Jesdianum Boiss. medicinal plants

Yousef Askari

Volume 10, Issue 1 , February 2022, , Pages 72-83

https://doi.org/10.22034/ijabbr.2022.545885.1374

Abstract

Background: Medicinal plants contain plant materials such as leaf, root, flower and seed using for producing drugs. Essential oils and extracts of various species of edible and medicinal ... Read More Background: Medicinal plants contain plant materials such as leaf, root, flower and seed using for producing drugs. Essential oils and extracts of various species of edible and medicinal plants, herbs, and spices constitute of very potent natural biologically active agents. Allium jesdianum Boiss and Dorema aucheri Boiss are an important and endangered medicinal plants that main habitats are located in the Zagros Mountains of Iran. Allium jesdianum (Alliaceae family) and Dorema aucheri belongs to Umbelliferae family were collected at summer 2020 from Yasouj in Kohgiluyeh and Boyer-ahmad province during to fruiting stage. The main purpose of this study was to evaluate composition of essential oil of Allium Jesdianum and Dorema aucheri from Kohgiluyeh and Boyer-ahmad province in south west of Iran.Methods: The essential oils of Allium jesdianum and Dorema aucheri were obtained by hydro distillation using a Clevenger type apparatus and in Dorema aucheri was extracted by n-hexane and were analyzed by GC/MS.Results: (E)-Caryophyllene (14.63%), γ-Cadinene (8.58%), Hexadecanoic acid (6.11%), Caryophyllene oxide (5.15%), (E,E)-α-Farnesene (4.05%), Z-Phytol (3.22%), δ-Cadinene (3.18%), Camphor (3.04%) and γ-Eudesmol (2.92%) were the most components of Dorema aucheri, whereas Hexadecanoic acid (18.34%%), Neral (Z-Citral) (13.74%), Dimethyl trisulfide (12.15%), Caryophyllene oxide (8.05%), Gereninal (E-Citral) (5.25%), Borneol (3.31%), Trans-propenyl propyl disulfide (3.17%), Geranyl acetate (2.74%), and β-Caryophyllene (2.65%) were the most constituents in Allium jesdianum oil, respectively.Conclusion: Kohgiluyeh and Boyer-Ahmad has good ethnobotanical potential for medicinal plants. This study is the first contribution to the ethnobotany of this region. We have gathered from this province some considerable knowledge about local medicinal plants such as Allium jesdianum and Dorema aucheri for treating common health problem that is ready to be further investigated in the laboratory.

The Toxicological effect of Cuscuta epithymum and Artemisia absinthium species on CP70 ovarian cancer cells

Homa Hakimian; Saeed Rezaei-Zarchi; Amaneh Javid

Volume 9, Issue 4 , December 2021, , Pages 331-339

https://doi.org/10.22034/ijabbr.2021.526486.1355

Abstract

Background: Ovarian cancer is one of the most common malignancies among women worldwide and is also the fifth leading cause of cancer death among women in recent years. Herbs have been ... Read More

Investigation of antibacterial and antifungal activities of essential oils of Lippia javanica and Lantana camara (Verbenaceae) harvested in the Haut-Katanga (DR Congo)

Mbayo Kitambala Marsi; Kalonda M Emery; Muhune K Simon; Numbi Wa Ilunga Evodie; Muyumba Nonga Welcome; Lukusa Kabeya Tresor; Misenga T Antoinette; Derek Ndinteh Tantoh; Mbayo Mukala Joseph; Maloba Mwinesenge James; Mulamba Muidikija Jean; Topwe Milongwe Mwene-Mbeja; Lumbu Simbi Jean-Baptiste

Volume 9, Issue 3 , September 2021, , Pages 254-269

https://doi.org/10.22034/ijabbr.2021.525721.1353

Abstract

Background: Essential oils are volatile compounds characterized by a strong odor, and are generally biosynthesized by aromatic plants as secondary metabolites. This paper aims to extract ... Read More Background: Essential oils are volatile compounds characterized by a strong odor, and are generally biosynthesized by aromatic plants as secondary metabolites. This paper aims to extract the essential oils of Lippia javanica and Lantana camara, and to evaluate their antibacterial, and antifungal activities.Methods: The aerial parts of Lippia javanica and Lantana camara were subjected to hydrodistillation to produce the essential oil. The antimicrobial potential was characterized against six microorganisms, signifying three Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa), two Gram-positive bacteria (Staphylococcus aureus and Streptococcus pneumoniae) and one fungus(Candida albicans) by the disc diffusion method to determine the inhibition zone (in mm) and dilution method to determine the minimal inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC).Results: Essential oil extraction was carried out with an average yield of 0.21% for Lippia javanica, and 0.11% for Lantana camara. The evaluation of the antimicrobial activity showed that Lippia javanica essential oil had a moderate inhibitory activity on Klebsiella pneumoniae, and Streptococcus pneumoniae (MIC: 0.76 mg/mL), on Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa (1.50 mg/mL). The Lantana camara essential oil showed weak inhibitory activity against all strains tested. By diffusion disk method, it was found that Klebsiella pneumoniae was the most sensitive on Lippia javanica essential oil with an inhibition diameter, which evolved from 7 mm to 24 mm; followed by Pseudomonas aeruginosa (21 mm), Escherichia coli (19 mm) and Streptococcus pneumoniae (13 mm) at 15 μL. By means of dilution method, the Lantana camara essential oil showed a low activity against Escherichia coli (MIC: 1.64 mg/mL), Klebsiella pneumonia (MIC: 1.64 mg/mL), Staphylococcus aureus (MIC: 3.28 mg/mL), Pseudomonas aeruginosa (MIC: 3.28 mg/mL), and Candida albicans (MIC: 3.28 mg/mL) but by disc diffusion method, this oil was slightly inhibitory activity on Escherichia coli (10 mm at 15 μL). For the antifungal activity, the Lantana camara essential oil, and Germicide were inactive on Candida albicans when tested by the disk method.Conclusion: The essential oil of Lippia javanica showed moderate antibacterial and antifungal activities, while the essential oil of Lantana camara showed low activity. The activities of essential oils studied were less than that of the gentamicin and more than the activity of Germicide, with two positive controls used.

Antibacterial activity of metabolites isolated from Streptomyces SSp. On Soil Sample of West Azerbaijan, Iran

Mohammad Reza Asgharzadeh; Nazar Manda

Volume 9, Issue 2 , June 2021, , Pages 147-159

https://doi.org/10.22034/ijabbr.2021.241642

Abstract

Background: The study for new antibiotics is of great importance in investigating programs around the worldwide for pharmaceutical, industrial and agricultural applications. Streptomyces ... Read More

The Effects of Probiotic, Prebiotic and Synbiotic on Growth Performance and Immune Responses of Broiler Chicks Challenged with Heat Stress by Multiattribute Decision-Making Method

Ebrahim Babakhani; Reza Rostamian

Volume 9, Issue 2 , June 2021, , Pages 181-189

https://doi.org/10.22034/ijabbr.2021.524089.1345

Abstract

Background: Heat stress (HS) has negative effects on economic parameters of the poultry industry. Different strategies such as nutritional additives are used to alleviate negative effects ... Read More

Pharmacognostic Features, Preliminary Phytochemical Screening and in Vitro Antioxidant Studies of Indigenous Plant of Lahore

Maida Minahil Mushtaq; Sohaib Peerzada; Saiqa Ishtiaq

Volume 9, Issue 2 , June 2021, , Pages 190-201

https://doi.org/10.22034/ijabbr.2021.523871.1344

Abstract

Introduction: Periploca aphylla is belongs to family Asclepiadaceae and it is an important traditional plant which has been utilized for decades for its local uses. Methods: This research ... Read More

The Effect Of Vitamin B12 and Folic Acid on Multiple Sclerosis in Mice

sahar Parchizadeh; Behrooz Salehi-Eskandari

Volume 9, Issue 2 , June 2021, , Pages 202-213

https://doi.org/10.22034/ijabbr.2021.524303.1347

Abstract

Background: Multiple sclerosis (MS) is an autoimmune disease in which a deficiency of vitamin B12 along with folic acid can contribute to its progression. The aim of this study was ... Read More

Nigella Sativa Hydro-Alcoholic Extract Attenuates Postpartum Depression Through Increase of Gamma Amino Butyric Acid-A Levels

Farzaneh Kianian; Tannaz Salehi; Seyed Shahabeddin Sadr; Zahra Tofighi; Elham Harati; Hamid Sadeghipour

Volume 9, Issue 1 , March 2021, , Pages 1-8

https://doi.org/10.22034/ijabbr.2021.43366

Abstract

Background: Postpartum depression (PPD) is one type of major depression that has harmful effects on mother, infant and family relationships. Therefore, this study investigated the protective ... Read More

Hypercholesterolemia Ameliorating Effect of Bangladeshi High Yield Variety Rice Bran Oil

Mohammad Azizur Rahman; Jannatul Ferdous; Shakir Hosen; Mahmudul Hasan; Afroza Parvin; Habibul Bari Shojib

Volume 9, Issue 1 , March 2021, , Pages 48-57

https://doi.org/10.22034/ijabbr.2021.44619

Abstract

Background: Hypercholesterolemia led cardiovascular disease (CVD) complications are plaguing the globe. In the present study,Bangladesh Rice Research Institute (BRRI) high yield variety ... Read More

Theoretical Evaluation of 5, 6-Diaroylisoindoline-1,3-dione as Potential Carcinogenic Kinase PAK1 Inhibitor: DFT Calculation, Molecular Docking Study and ADMET Prediction

Mohammad Mazharol Hoque; Ajoy Kumer; Md. Sajib Hussen; Md Wahab Khan

Volume 9, Issue 1 , March 2021, , Pages 77-104

https://doi.org/10.22034/ijabbr.2021.45696

Abstract

Background: The carcinogenic kinase PAK1 (p21-activated kinase 1) is associated with the progression of many disorders, including Alzheimer's disease, various cancers, type-2 diabetes ... Read More

Antibacterial and Anti biofilm effects of ethanol and aceton leaf extract of Momordica charantia and Tecomella undulata against Acinetobacter baumannii

Moharam Valizadeh; Maryam Beigomi; Bahman Fazeli-Nasab

Volume 8, Issue 4 , November and December 2020, , Pages 403-418

https://doi.org/10.22034/ijabbr.2020.40523

Abstract

Background: Considering the increasing resistance of bacteria to antibiotics and the presence of antibacterial agents in plantsObjectives: the aim of this study was the antimicrobial ... Read More

Survival and Growth Promoting Effects of Bacillus subtilis on Macrobrachium rosenbergii, and Validation of Gut Microflora

Periyakali Saravana Bhavan; Duraisamy Anitha; Thankaraj Manjula; Rajendran Udayasuriyan; Ramasamy Kalpana; Madhayan Karthik

Volume 8, Issue 4 , November and December 2020, , Pages 440-460

https://doi.org/10.22034/ijabbr.2020.43288

Abstract

This work emphasized the survival and growth of the commercially important freshwater prawn, Macrobrachium rosenbergii post-larvae on formulated diets supplemented with a probiotic ... Read More

Antibacterial Efficacy of Garcinia kola (Heckel) Seeds against Bacteria Involved in Throat Infections

Elizabeth Idowu; Olubukola Olusola-Makinde; Muftau Oladunmoye

Volume 8, Issue 3 , September and October 2020, , Pages 253-267

https://doi.org/10.33945/SAMI/IJABBR.2020.3.4

Abstract

Throat infections are common cause for visit to health care centres. This study is aimed at investigating the antibacterial efficacy of G. kola seeds against bacteria involved in throat ... Read More

In vitro elaboration Mutagenesis and cloning of the PA gene in Bacillus subtilis

Mohammad Abootaleb; Narjes Mohammadi Bandari

Volume 8, Issue 3 , September and October 2020, , Pages 284-290

https://doi.org/10.33945/SAMI/IJABBR.2020.3.6

Abstract

Background: The immune antigen of Bacillus anthracis is a protein that can attach to the surface receptor of all human cells. At the surface of cancer cells, there is a receptor that ... Read More

Volume 10 (2022)

Volume 9 (2021)

Volume 8 (2020)

Volume 7 (2019)

Volume 6 (2018)

Volume 5 (2017)

Volume 4 (2016)

Volume 3 (2015)

Volume 2 (2014)

Volume 1 (2013)

Main Subjects = Biological Sciences

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